A randomized study comparing the safety and immunogenicity of a conjugate vaccine combination containing meningococcal group C and pneumococcal capsular polysaccharide-CRM197 with a meningococcal group C conjugate vaccine in healthy infants: Challenge phase

Vaccine

Volumn 25, Issue 19, 2007, Pages 3906-3912

  Riddell, Anna ^a   Buttery, Jim P ^a   McVernon, Jodie ^a   Chantler, Tracey ^a   Lane, Laura ^b   Bowen Morris, Jane ^a   Diggle, Linda ^a   Morris, Rhonwen ^b   Lockhart, Steven ^c   Pollard, Andrew J ^a   Cartwright, Keith ^b   Moxon, E Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLOUCESTERSHIRE ROYAL HOSPITAL   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

Avidity; Conjugate vaccine; Meningococcal; Pneumococcal

Indexed keywords

BACTERIUM ANTIBODY; MENINGOCOCCUS ANTIBODY; MENINGOCOCCUS VACCINE; PNEUMOCOCCUS POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANOREXIA; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYING; DROWSINESS; DRUG MIXTURE; DRUG SAFETY; FEMALE; FEVER; HUMAN; IMMUNOGENICITY; INFANT; INJECTION SITE ERYTHEMA; INJECTION SITE REACTION; INJECTION SITE SWELLING; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENINGOCOCCOSIS; NEISSERIA MENINGITIDIS; PHASE 2 CLINICAL TRIAL; PHYSICAL ACTIVITY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; VACCINATION;

ANTIBODIES, BACTERIAL; ANTIBODY AFFINITY; BACTERIAL PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNIZATION; IMMUNIZATION, SECONDARY; INFANT; MENINGITIS, MENINGOCOCCAL; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; NEISSERIA MENINGITIDIS, SEROGROUP C; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; POLYSACCHARIDES, BACTERIAL; VACCINES, CONJUGATE;

EID: 34247225483     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.01.097     Document Type: Article

References (18)

1. Buttery J., Riddell A., McVernon J., et al. Immunogenicity and safety of a combination conjugate pneumococcal-meningococcal group C vaccine in infants. JAMA 293 14 (2005) 1751-1758
2. Goldblatt D., Vaz A.R., and Miller E. Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccine following infant immunisation. JID 177 (1998) 1112-1115
3. Antilla M., Eskola J., Ahman H., and Kayhty H. Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines. JID 177 (1998) 1614-1621
4. Richmond P., Kaczmarski E., Borrow R., Findlow J., Clark S., McCann R., et al. Meningococcal C polysaccharide vaccine induces immunologic hyporesponsiveness in adults that is overcome by meningococcal C conjugate vaccine. JID 181 2 (2000) 761-764
5. Borrow R., and Carlone G.M. Serogroup B and C serum bactericidal assays. In: Pollard A.J., and Maiden M.C.J. (Eds). Meningococcal vaccines. Methods in molecular medicine (2001), Humana Press, Totowa, NJ 289-304
6. Granoff D.M., Maslanka S.E., Carlone G.M., Plikaytis B.D., Santos G.F., Mokatrin A., et al. A modified enzyme-linked immunosorbent assay for measurement of antibody responses to meningococcal c polysaccharide that correlate with bactericidal responses. Clin Diagn Lab Immunol 5 4 (1998) 479-485
7. Goldblatt D. Simple solid phase assays of avidity. In: Turner M.W., and Johnson A.P. (Eds). Immunochemistry. 2: A practical approach (1997), IRL Press at Oxford University Press, Oxford, UK 31-51
8. Joseph H., Miller E., Dawson M., Andrews N., Feavers I., and Borrow R. Meningococcal serogroup a avidity indices as a surrogate marker of priming for the induction of immunological memory after vaccination with a meningococcal a/c conjugate vaccine in infants in the United Kingdom. JID 184 (2001) 661-662
9. English M., Maclennan J.M., Bowen-Morris J.M., et al. A randomized, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. Vaccine 19 (2000) 1232-1238
10. Richmond P., Borrow R., Miller E., et al. Meningococcal serogroup C vaccine is immunogenic in infancy and primes for memory. JID 179 (1999) 1569-1572
11. Borrow R., Andrews N., Goldblatt D., and Miller E. Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: re-evaluation of correlates of protection. Infect Immunol 69 (2001) 1568-1573
12. McVernon J., Johnson P.D., Pollard A.J., Slack M.P., and Moxon E.R. Immunologic memory in Haemophilus influenzae type b conjugate vaccine failure. Arch Dis Child 88 (2003) 379
13. Trotter C., Andrews N., Kaczmarski E., Miller E., and Ramsey M.E. Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction. Lancet 364 (2004) 365-367
14. Burrage M., Robinson A., Borrow R., et al. Effect of vaccination with carrier protein on response to meningococcal C conjugate vaccines and value of different immunoassays as predictors of protection. Infect Immunol 70 9 (2002) 4946-4954
15. Dagan R., Eskola J., Leclerc C., and Leroy O. Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants. Infect Immunol 66 (1998) 2093-2098
16. Goldblatt D., Borrow R., and Miller E. Natural and vaccine-induced immunity and immunological memory to Neisseria meningitidis serogroup C in young adults. JID 185 (2002) 397-400
17. Borrow R., Goldblatt D., Andrews N., et al. Antibody persistence and immunological memory at age 4 years after meningococcal group C conjugate vaccination in children in the United Kingdom. JID 186 (2002) 1353-1357
18. Richmond P., Borrow R., Goldblatt D., et al. Ability of 3 different meningococcal c conjugate vaccines to induce immunologic memory after a single dose in UK toddlers. JID 183 (2001) 160-163