In vitro models for evaluation of hyperbaric oxygen therapy in wound healing: A review

Diving and Hyperbaric Medicine

Volumn 37, Issue 1, 2007, Pages 25-30

  Malda, Jos ^a   Dawson, Rebecca A ^a   Kairuz, Evette ^a   Topping, Gemma ^a   Long, Robert ^b   Upton, Zee ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b Wesley Ctr for Hyperbaric Medicine   (Australia)

Author keywords

Chronic wounds; Human skin equivalent; Hyperbaric oxygen; Models; Research; Review article

Indexed keywords

BICARBONATE; CARBON DIOXIDE; COLLAGEN; GLUCOSE; OXYGEN;

AIR; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL TYPE; COLLAGEN SYNTHESIS; CULTURE MEDIUM; DIABETES MELLITUS; EPIDERMIS; GAS EXCHANGE; HUMAN; HYPERBARIC OXYGEN; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTERMETHOD COMPARISON; KERATINOCYTE; OXYGEN TENSION; PRESSURE CHAMBER; REVIEW; THERMOREGULATION; WOUND HEALING; WOUND HEALING IMPAIRMENT;

EID: 34247223795     PISSN: 18333516     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Simon DA, Dix FP, McCollum CN. Management of venous leg ulcers. BMJ. 2004; 328: 1358-62.
2. Tandara AA, Mustoe TA. Oxygen in wound healing - more than a nutrient. World J Surg. 2004; 28: 294-300.
3. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972; 135: 561-7.
4. Bonomo SR, Davidson JD, Tyrone JW, Lin X, Mustoe TA. Enhancement of wound healing by hyperbaric oxygen and transforming growth factor beta3 in a new chronic wound model in aged rabbits. Arch Surg. 2000; 135: 1148-53.
5. Uhl E, Sirsjo A, Haapaniemi T, Nilsson G, Nylander G. Hyperbaric oxygen improves wound healing in normal and ischemic skin tissue. Plast Reconstr Surg. 1994; 93: 835-41.
6. Zhao LL, Davidson JD, Wee SC, Roth SI, Mustoe TA. Effect of hyperbaric oxygen and growth factors on rabbit ear ischemic ulcers. Arch Surg. 1994; 129: 1043-9.
7. Hammarlund C, Sundberg T. Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. Plast Reconstr Surg. 1994; 93: 829-34.
8. Kessler L, Bilbault P, Ortega F, Grasso C, Passemard R, et al. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study. Diabetes Care. 2003; 26: 2378-82.
9. Faglia E, Favales F, Aldeghi A, Calia P, Quarantiello A, et al. Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. Diabetes Care. 1996; 19: 1338-43.
10. Medical Services Advisory Committee. Hyperbaric oxygen therapy. Assessment Report 1054; 2003. Available at .
11. Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg. 2005; 92: 24-32.
12. Hehenberger K, Bismar K, Lind F, Kratz G. Dose-dependent hyperbaric oxygen stimulation of human fibroblast proliferation. Wound Repair Regen. 1997; 5: 147-50.
13. Tompach P, Lew D, Stoll J. Cell response to hyperbaric oxygen treatment. Int J Oral Maxillofac Surg. 1997; 26: 82-6.
14. Piepmeier EH, Kalns JE. Fibroblast response to rapid decompression and hyperbaric oxygenation. Aviat Space Environ Med. 1999; 70: 589-93.
15. Dimitrijevich SD, Paranjape S, Wilson JR, Gracy RW, Mills JG. Effect of hyperbaric oxygen on human skin cells in culture and in human dermal and skin equivalents. Wound Repair Regen. 1999; 7: 53-64.
16. Hollander DA, Hakimi MY, Hartmann A, Wilhelm K, Windolf J. The influence of hyperbaric oxygenation (HBO) on proliferation and differentiation of human keratinocyte cultures in vitro. Cell Tissue Bank. 2000; 1: 261-9.
17. Bakker D, Cramer F. Hyperbaric surgery. Flagstaff, AZ: Best Publishing Company; 2002.
18. Sun T, Jackson S, Haycock JW, MacNeil S. Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. J Biotechnol. 2006; 122: 372-81.
19. Ponec M. Skin constructs for replacement of skin tissues for in vitro testing. Adv Drug Deliv Rev. 2002; 54: S19-30.
20. Chakrabarty KH, Dawson RA, Harris P, Layton C, Babu M, et al. Development of autologous human dermal-epidermal composites based on sterilized human allodermis for clinical use. Br J Dermatol. 1999; 141: 811-23.
21. Kairuz E, Dawson RA, Upton Z, Malda J. Hyperbaric oxygen stimulates epidermal reconstruction in human skin equivalents. Wound Repair Regen. 2007; 15: 265-73.
22. Topping G, Malda J, Dawson R, Upton Z. Development and characterisation of human skin equivalents and their potential application as a burn wound model. Primary Intention. 2006; 14: 14-21.
23. Smola H, Stark HJ, Thiekotter G, Mirancea N, Krieg T, Fusenig NE. Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture. Exp Cell Res. 1998; 239: 399-410.
24. Breetveld M, Richters CD, Rustemeyer T, Scheper RJ, Gibbs S. Comparison of wound closure after burn and cold injury in human skin equivalents. J Invest Dermatol. 2006; 126: 1918-21.
25. Chakrabarty KH, Heaton M, Dalley AJ, Dawson RA, Freedlander E, et al. Keratinocyte-driven contraction of reconstructed human skin. Wound Repair Regen. 2001; 9: 95-106.
26. Eves P, Katerinaki E, Simpson C, Layton C, Dawson R, et al. Melanoma invasion in reconstructed human skin is influenced by skin cells - investigation of the role of proteolytic enzymes. Clin Exp Metastasis. 2003; 20: 685-700.
27. Sahota PS, Burn JL, Heaton M, Freedlander E, Suvarna SK, et al. Development of a reconstructed human skin model for angiogenesis. Wound Repair Regen. 2003; 11: 275-84.
28. Fujimoto N, Itoh Y, Tajima S, Ishibashi A. Keratinocytes cultured under hyperthermal conditions secrete factor(s) which can modulate dermal fibroblast proliferation and extracellular matrix production. Acta Derm Venereol. 1997; 77: 428-31.
29. El Ghalbzouri A, Hensbergen P, Gibbs S, Kempenaar J, van der Schors R, Ponec M. Fibroblasts facilitate re-epithelialization in wounded human skin equivalents. Lab Invest. 2004; 84: 102-12.