Designing active template molecules by combining computational de novo design and human chemist's expertise

Journal of Medicinal Chemistry

Volumn 50, Issue 8, 2007, Pages 1925-1932

  Lameijer, Eric Wubbo ^a   Tromp, Reynier A ^a   Spanjersberg, Ronald F ^a   Brussee, Johannes ^a   IJzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; BIOGENIC AMINE; CARRIER PROTEIN; G PROTEIN COUPLED RECEPTOR;

ARTICLE; COMPUTER PROGRAM; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HYDROGEN BOND; LIGAND BINDING; MOLECULAR WEIGHT; REACTION ANALYSIS;

ALGORITHMS; ANILINE COMPOUNDS; ANIMALS; CARRIER PROTEINS; CHEMISTRY, PHARMACEUTICAL; DATABASES, FACTUAL; DRUG DESIGN; FEASIBILITY STUDIES; FURANS; HUMANS; ION CHANNELS; MODELS, MOLECULAR; NA(+)-K(+)-EXCHANGING ATPASE; PHARMACEUTICAL PREPARATIONS; PHOSPHORIC DIESTER HYDROLASES; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247217238     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061356+     Document Type: Article

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