Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype

Brazilian Journal of Medical and Biological Research

Volumn 40, Issue 4, 2007, Pages 583-5890

  Velloso, E P ^a   Vieira, R ^a   Cabral, A C ^a   Kalapothakis, E ^a   Santos, Robson A S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

ACE polymorphism (I D); Angiotensin (1 7); Angiotensin converting enzyme; Preeclampsia; Renin; Renin angiotensin system

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN[1-7]; DIPEPTIDYL CARBOXYPEPTIDASE; RENIN;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; FISHER EXACT TEST; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY; RADIOIMMUNOASSAY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 34247209761     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/s0100-879x2007000400018     Document Type: Article

References (27)

1. Anonymous. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
2. Talosi G, Endreffy E, Turi S, Nemeth I. Molecular and genetic aspects of preeclampsia: state of the art. Mol Genet Metab 2000; 71: 565-572.
3. Neves LA, Williams AF, Averill DB, Ferrario CM, Walkup MP, Brosnihan KB. Pregnancy enhances the angiotensin (Ang)-(1-7) vasodilator response in mesenteric arteries and increases the renal concentration and urinary excretion of Ang-(1-7). Endocrinology 2003; 144: 3338-3343.
4. Gordon RD, Symonds EM, Wilmshurst EG, Pawsey CG. Plasma renin activity, plasma angiotensin and plasma and urinary electrolytes in normal and toxaemic pregnancy, including a prospective study. Clin Sci 1973; 45: 115-127.
5. Crackower MA, Sarao, R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, at al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002; 417: 822-828.
6. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA 2003; 100: 8258-8263.
7. Merrill DC, Karoly M, Chen K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) in normal and preeclamptic pregnancy. Endocrine 2002; 18: 239-245.
8. Santos RA, Campagnole-Santos MJ, Andrade SP. Angiotensin-(1-7): an update. Regul Pept 2000; 91: 45-62.
9. Jalil JE, Palomera C, Ocaranza MP, Godoy I, Roman M, Chiong M, et al. Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype. Am J Cardiol 2003; 92: 749-751.
10. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
11. Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzales MF, et al. Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 1994; 90: 669-676.
12. Neves LA, Almeida AP, Khosla MC, Santos RA. Metabolism of angiotensin I in isolated rat hearts. Effect of angiotensin converting enzyme inhibitors. Biochem Pharmacol 1995; 50: 1451-1459.
13. Chappell MC, Brosnihan KB, Diz DI, Ferrario CM. Identification of angiotensin-(1-7) in rat brain. Evidence for differential processing of angiotensin peptides. J Biol Chem 1989; 264: 16518-16523.
14. Santos RA, Krieger EM, Greene LJ. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension 1985; 7: 244-252.
15. Ueda S, Heeley RP, Lees KR, Elliott HL, Connell JM. Mistyping of the human angiotensin-converting enzyme gene polymorphism: frequency, causes and possible methods to avoid erron; in typing. J Mol Endocrinol 1996; 17: 27-30.
16. Valdes G, Germain AM, Corthorn J, Berrios C, Foradori AC, Ferrario CM, et al. Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactation. Endocrine 2001; 16: 117-122.
17. Sampaio WO, Nascimento AA, Santos RA. Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats. Am J Physiol Heart Circ Physiol 2003; 284: H1985-H1994.
18. Luque M, Martin P, Martell N, Fernandez C, Brosnihan KB, Ferrario CM. Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension. J Hypertens 1996; 14: 799-805.
19. Ferrario CM, Smith RD, Brosnihan B, Chappell MC, Campese VM, Vesterqvist O, et al. Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension. Am J Hypertens 2002; 15: 557-564.
20. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, et al. Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension 2003; 42: 749-753.
21. Weiner CP, Knowles RG, Moncada S. Induction of nitric oxide synthases early in pregnancy. Am J Obstet Gynecol 1994; 171: 838-843.
22. Langer B, Grima M, Coquard C, Bader AM, Schlaedler G, Imbs JL. Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia. Obstet Gynecol 1998; 91: 196-202.
23. Tamura T, Johanning GL, Goldenberg RL, Johnston KE, DuBard MB. Effect of angiotensin-converting enzyme gene polymorphism on pregnancy outcome, enzyme activity, and zinc concentration. Obstet Gynecol 1996; 88: 497-502.
24. Ito M, Itakura A, Ohno Y, Nomura M, Senga T, Nagasaka T, et al. Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. J Clin Endocrinol Metab 2002; 87: 1871-1878.
25. Gurdöl F, Isbilen E, Yilmaz H, Isbir T, Dirican A. The association between presclampsia and angiotensin-converting enzyme insertion/ deletion polymorphism. Clin Chim Acta 2004; 341: 127-131.
26. August P, Mueller FB, Sealey JE, Edersheim TG. Role of renin-angiotensin system in blood pressure regulation in pregnancy. Lancet 1995; 345: 896-897.
27. Weir RJ, Brown JJ, Fraser R, Kraszewski A, Lever AF, Mcllwaine GM, et al. Plasma renin, renin substrate, angiotensin II, and aldosterone in hypertensive disease of pregnancy. Lancet 1973; 1: 291-294.