Ferrous ion-induced strand breaks in the DNA plasmid pBR322 are not mediated by hydrogen peroxide

European Biophysics Journal

Volumn 36, Issue 4-5, 2007, Pages 377-384

  Flemmig, Jörg ^a   Arnhold, Jürgen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Agarose gel electrophoresis; Autoxidation; DNA degradation; Fenton reaction; Ferrous ions; Strand breaks

Indexed keywords

BICARBONATE; BUFFER; CATALASE; FERROUS GLUCONATE; FERROUS ION; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; OXYGEN; PHENANTHROLINE; PHOSPHATE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ARTICLE; AUTOOXIDATION; CHEMISTRY; COMPLEX FORMATION; DNA DEGRADATION; DNA STRAND BREAKAGE; ELECTROPHORETIC MOBILITY; INTRACELLULAR SPACE; LINEAR SYSTEM; NONHUMAN; PH; PLASMID;

DNA DAMAGE; FERROUS COMPOUNDS; HYDROGEN PEROXIDE; IONS; PLASMIDS;

EID: 34247196158     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-006-0093-3     Document Type: Article

References (32)

1. Aruoma OI, Halliwell B, Gajewski E, Dizdaroglu M (1991) Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J 273:601-604
2. Augusto O, Bonini MG, Amanso AM, Linares E, Santos CCX, De Menezes SL (2002) Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. Free Radic Biol Med 32:841-859
3. Beers RJ Jr, Sizer IW (1952) A spectrometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195:133-140
4. Biaglow JE, Kachur AV (1997) The generation of hydroxyl radicals in the reaction of molecular oxygen with polyphosphate complexes of ferrous ions. Radiat Res 148:181-187
5. Bonini MG, Augusto O (2001) Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite. J Biol Chem 276:9749-9754
6. Bonini MG, Fernandes DC, Augusto O (2004) Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals. Biochemistry 43:344-351
7. Crichton RR, Ward RJ (1998) Iron homeostasis. Met Ions Biol Syst 35:633-665
8. Goldstein S, Meyerstein D, Czapski G (1993) The Fenton reagents. Free Radic Biol Med 15:435-445
9. Gunther MR, Hanna PM, Mason RP, Cohen MS (1995) Hydroxyl radical formation from cuprous ion and hydrogen peroxide: a spin-trapping study. Arch Biochem Biophys 316:515-522
10. Halliwell B, Aruoma OI (1991) DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 281:9-19
11. Halliwell B, Gutteridge JMC (1988) Iron as a biological pro-oxidant. ISI Atlas Sci: Biochem 48-52
12. Kakhlon O, Cabantchik ZI (2002) The labile iron pool: characterization, measurement, and participation in cellular processes. Free Radic Biol Med 33:1037-1046
13. Kasprzak KS (2002) Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis. Free Radic Biol Med 32:958-967
14. Keyer K, Imlay JA (1996) Superoxide accelerates DNA damage by elevating free-iron levels. Proc Natl Acad Sci USA 93:13635-13640
15. Koppenol WH (1993) The centennial of the Fenton reaction. Free Radic Biol Med 15:645-651
16. Kruszewski M (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531:81-92
17. Miller DM, Aust SD (1981) Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation. Arch Biochem Biophys 271:113-119
18. Miller DM, Buettner GR, Aust SD (1990) Transition metals as catalysts of "autoxidation" reactions. Free Radic Biol Med 8:95-108
19. Minotti G, Aust SD (1987) The role of iron in the initiation of lipid peroxidation. Chem Phys Lipids 44:191-208
20. Ponka P (1999) Cellular iron metabolism. Kidney Int 55:S2-S11
21. Qian SY, Buettner GR (1999) Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study. Free Radic Biol Med 26:1447-1456
22. Reinke LA, Rau JM, McCay PB (1994) Characteristics of an oxidant formed during iron(II) autoxidation. Free Radic Biol Med 16:485-492
23. Rice-Evans C, Diplock AT, Symons MCR (1991) Techniques in free radical research. Elsevier, San Diego
24. Richardson DE, Regino CAS, Yao H, Johnson JV (2003) Methionine oxidation by peroxymonocarbonate, a reactive oxygen species formed from CO2/bicarbonate and hydrogen peroxide. Free Radic Biol Med 35:1538-1550
25. Rush JD, Koppenol WH (1986) Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. J Biol Chem 261:6730-6735
26. Ryan TP, Aust SD (1992) The role of iron in oxygen-mediated toxicities. Crit Rev Toxicol 22:119-141
27. Saran M, Michel C, Stettmaier K, Bors W (2000) Arguments against the significance of the Fenton reaction contributing to signal pathways under in vivo conditions. Free Radic Res 33:567-579
28. von Sonntag C (1985) The chemical basis of radiation biology. Taylor & Francis, London
29. von Sonntag C (1994) Topics in free radical-mediated DNA damage: purines and damage amplification-superoxic reactions-bleomycin, the incomplete radiomimetic. Int J Radiat Biol 66:485-490
30. + with dioxygen; comparison with the Fenton chemistry. Acta Biochim Pol 47:951-962
31. Wardman P, Candeias LP (1996) Fenton chemistry: an introduction. Radiat Res 145:523-531
32. Yegorov DY, Kozlov AV, Azizova OA, Vladimirov YA (1993) Simultaneous determination of Fe(III) and Fe(II) in water solutions and tissue homogenates using desferal and 1,10-phenanthroline. Free Radic Biol Med 15:565-574