Iron(III) chloride-catalyzed reductive etherification of carbonyl compounds with alcohols

Chemistry Letters

Volumn 36, Issue 1, 2007, Pages 38-39

  Iwanami, Katsuyuki ^a   Yano, Kentaro ^a   Oriyama, Takeshi ^a  

^a IBARAKI UNIVERSITY   (Japan)

Author keywords

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Indexed keywords

EID: 34247184762     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2007.38     Document Type: Article

References (24)

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24. Typical procedure: To a suspension of anhydrous iron(III) chloride (2.4 mg, 0.015 mmol) and benzaldehyde (30 μL, 0.30 mmol) in nitromethane (1.5 mL) was added 3-phenylpropanol (49.1 mg, 0.36 mmol) and triethylsilane (58 μL, 0.36 mmol) successively at room temperature under an argon atmosphere. After stirring for 1 h, the reaction mixture was quenched with a phosphate buffer (pH 7, 20 mL). The organic materials were extracted with dichloromethane, washed with brine, and dried over sodium sulfate. 1-Benzyloxy-3-phenylpropane (64.9 mg, 97%) was isolated by thin-layer chromatography on silica gel.