Removal of C-ring from the CD-ring skeleton of 1α,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly

Archives of Biochemistry and Biophysics

Volumn 460, Issue 2, 2007, Pages 254-261

  Satyanarayana Reddy, G ^a,b   Robinson, Matthew ^a   Wang, Guochun ^c   Palmore, G Tayhas R ^c   Gennaro, Lynn ^d   Vouros, Paul ^d   De Clercq, Pierre ^e   Vandewalle, Maurits ^e   Young, Wu ^e   Ling, Shi ^e   Verstuyf, Annemieke ^f   Bouillon, Roger ^f  

^a Epimer LLC   (United States)

^b BROWN UNIVERSITY   (United States)

^c Brown University   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e GHENT UNIVERSITY   (Belgium)

^f UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

1 ,25(OH)2D3; C 24 oxidation pathway; C 3 epimerization pathway; D ring analogs; Metabolism; Nonsteroidal vitamin D analogs; SL 117; Vitamin D; WU 515

Indexed keywords

CALCITRIOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CHEMICAL STRUCTURE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERCALCEMIA; ISOLATED KIDNEY; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RAT; SYNTHESIS; TISSUE METABOLISM; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; CALCITRIOL; CELL PROLIFERATION; HYPERCALCEMIA; KIDNEY; MALE; NEOPLASMS; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; VITAMINS;

RATTUS;

EID: 34247172178     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.11.012     Document Type: Article

References (30)

1. Bouillon R., Okamura W.H., and Norman A.W. Endocrine Reviews 16 (1995) 200-257
2. DeLuca H.F. American Journal of Clinical Nutrition 80 (2004) 1689S-1696S
3. Nagpal S., Na S.Q., and Rathnachalam R. Endocrine Reviews 26 (2005) 662-687
4. Bouillon R., Verlinden L., Eelen G., De Clercq P., Vandewalle M., Mathieu C., and Verstuyf A. Journal of Steroid Biochemistry and Molecular Biology 97 (2005) 21-30
5. Masuda S., and Jones G. Molecular Cancer Therapeutics 5 (2006) 797-808
6. Verstuyf A., Verlinden L., Van Baelen H., Sabbe K., D'Hallewyn C., De Clercq P., Vandewalle M., and Bouillon R. Journal of Bone and Mineral Research 13 (1998) 549-558
7. Verstuyf A., Verlinden L., Van Etten E., Shi L., Wu Y.S., D'Halleweyn C., Van Haver D., Zhu G.D., Chen Y.J., Zhou X.M., Haussler M.R., De Clercq P., Vandewalle M., Van Baelen H., Mathieu C., and Bouillon R. Journal of Bone and Mineral Research 15 (2000) 237-252
8. Reddy G.S., and Tserng K.Y. Biochemistry 28 (1989) 1763-1769
9. Makin G., Lohnes D., Byford V., Ray R., and Jones G. Biochemical Journal 262 (1989) 173-180
10. Siu-Caldera M.L., Sekimoto H., Weiskopf A., Vouros P., Muralidharan K.R., Okamura W.H., Bishop J., Norman A.W., Uskokovic M.R., Schuster I., and Reddy G.S. Bone 24 (1999) 457-463
11. Reddy G.S., Muralidharan K.R., Okamura W.H., Tserng K.Y., and McLane J.A. Steroids 66 (2001) 441-450
12. Masuda S., Kamao M., Schroeder N.J., Makin H.L.J., Jones G., Kremer R., Rhim J., and Okano T. Biological & Pharmaceutical Bulletin 23 (2000) 133-139
13. Horst R.L., Reinhardt T.A., and Reddy G.S. In: Feldman D., Pike J.W., and Glorieux F.H. (Eds). Vitamin D (2005), Elsevier Academic Press 15-36
14. Reddy G.S., Clark J.W., Tserng K.Y., Uskokovic M.R., and McLane J.A. Bioorganic & Medicinal Chemistry Letters 3 (1993) 1879-1884
15. Siu-Caldera M.L., Clark J.W., SantosMoore A., Peleg S., Liu Y.Y., Uskokovic M.R., Sharma S., and Reddy G.S. Journal of Steroid Biochemistry and Molecular Biology 59 (1996) 405-412
16. Siu-Caldera M.L., Sekimoto H., Peleg S., Nguyen C., Kissmeyer A.M., Binderup L., Weiskopf A., Vouros P., Uskokovic M.R., and Reddy G.S. Journal of Steroid Biochemistry and Molecular Biology 71 (1999) 111-121
17. Reddy G.S., Tserng K.Y., Thomas B.R., Dayal R., and Norman A.W. Biochemistry 26 (1987) 324-331
18. Yong W., Ling S., Dhalleweyn C., VanHaver D., De Clercq P., and Vandewalle M. Bioorganic & Medicinal Chemistry Letters 7 (1997) 923-928
19. Reddy G.S., Jones G., Kooh S.W., Fraser D., and Deluca H.F. American Journal of Physiology 245 (1983) E359-E364
20. Bligh E.G., and Dyer W.J. Canadian Journal of Biochemistry and Physiology 37 (1959) 911-917
21. Uskokovic M.R., Norman A.W., Manchand P.S., Studzinski G.P., Campbell M.J., Koeffler H.P., Takeuchi A., Siu-Caldera M.L., Rao D.S., and Reddy G.S. Steroids 66 (2001) 463-471
22. Kiriyama T., Okamoto S., Ejima E., Kurihara N., Hakeda Y., Ito N., Izumi M., Kumegawa M., and Nagataki S. Endocrinology 128 (1991) 81-86
23. Brown A.J., Berkoben M., Ritter C., Kubodera N., Nishii Y., and Slatopolsky E. Biochemical and Biophysical Research Communications 189 (1992) 759-764
24. Honda A., Nakashima N., Mori Y., Katsumata T., and Ishizuka S. Journal of Steroid Biochemistry and Molecular Biology 41 (1992) 109-112
25. Harada M., Miyahara T., Kajitakondo S., Kozakai A., Higuchi S., Otomo S., and Kozuka H. Research Communications in Molecular Pathology and Pharmacology 86 (1994) 183-193
26. Dilworth F.J., Williams G.R., Kissmeyer A.M., Nielsen J.L., Binderup E., Calverley M.J., Makin H.L.J., and Jones G. Endocrinology 138 (1997) 5485-5496
27. Dilworth F.J., Calverley M.J., Makin H.L.J., and Jones G. Biochemical Pharmacology 47 (1994) 987-993
28. Lemire J.M., Archer D.C., and Reddy G.S. Endocrinology 135 (1994) 2818-2821
29. Campbell M.J., Reddy G.S., and Koeffler H.P. Journal of Cellular Biochemistry 66 (1997) 413-425
30. Reddy G.S., Rao D.S., Siu-Caldera M.L., Astecker N., Weiskopf A., Vouros P., Sasso G.J., Manchand P.S., and Uskokovic M.R. Archives of Biochemistry and Biophysics 383 (2000) 197-205