Preparation of apoptotic inducers, 2,2-diphenyl-1,3,2-oxazaborolidin-5- ones, under alkaline conditions

Synlett

Volumn , Issue 6, 2007, Pages 921-924

  Velasco Bejarano, Benjamín ^a,b   Trujillo Ferrara, José ^a   Miranda, René ^b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

amino acids; Apoptosis; Boron complexes; Diphenylborinic acid; Diphenyloxazaborolidinones

Indexed keywords

2,2 DIPHENYL 1,3,2 OXAZABOROLIDIN 5 ONE; ALPHA AMINO ACID; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKALINITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PH MEASUREMENT; STRUCTURE ANALYSIS;

EID: 34247169495     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-973886     Document Type: Article

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16. 2O and n-hexane, yielding 1.49 g of 3a (6.26 mmol, 94%).
17. 2O and then sulforhodamine (SRB, 100 μL, 0.4%) dissolved in AcOH (1%) was added to each well and left for 15 min. The SRB was removed, washed in AcOH (1%) and allowed to air-dry. Then aqueous Tris base [tris(hydroxymethyl)aminoethane] (100 μL, 10 mM) was added to each well to solubilize the cell-bound dye and the absorbance at 550 nm was measured. The results are expressed as a percentage of control cell growth.
18. 6): δ = +5.03; MS (EI): m/z = 239, 238, 162 (base peak), 161, 132, 104, 77.