Impact of iron deficiency anaemia on T lymphocytes & their subsets in children

Indian Journal of Medical Research

Volumn 124, Issue DEC., 2006, Pages 647-654

  Mullick, Shalini ^a   Rusia, Usha ^b   Sikka, Meera ^b   Faridi, M A ^b  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^b UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Cell mediated immunity; Iron deficiency; T lymphocytes

Indexed keywords

ALBENDAZOLE; FERROUS SULFATE; TRACE ELEMENT; CD3 ANTIGEN;

ARTICLE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG EFFICACY; HEMATOLOGIC DISEASE; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IRON DEFICIENCY ANEMIA; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; T LYMPHOCYTE SUBPOPULATION; TREATMENT DURATION; CD4 LYMPHOCYTE COUNT; IMMUNOLOGY; INFANT; T LYMPHOCYTE;

ANEMIA, IRON-DEFICIENCY; ANTIGENS, CD3; CD4 LYMPHOCYTE COUNT; CD4-CD8 RATIO; CHILD, PRESCHOOL; HUMANS; IMMUNITY, CELLULAR; INFANT; T-LYMPHOCYTES;

EID: 34247164126     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. UNICEF/UNO/WHO/MI. Preventing iron deficiency in women and children. Technical consensus on key issues. International Nutrition Foundation, Buston, MA; 1999 p. 1-60.
2. Hercberg S, Galan P. Biochemical effects of iron depletion. Acta Pediatr Scand 1989; 361 (Suppl): 63-70.
3. Beard JL. Iron biology in immune function, muscle metabolism, and neuronal functioning. J Nutr 2001; 131 (Suppl 2): 568s-80s.
4. Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron deficiency anemia on the function of the immune system. Hematol J 2005; 5: 579-83.
5. Tang YM, Chen XZ, Li GR, Zhou RH, Ning H, Yan H. Effects of iron deficiency anemia on immunity and infectious disease in pregnant women. Wei Sheng Yan Jiu 2006; 35: 79-81.
6. Chandra RK, Saraya AK. Impaired immunocompetence associated with iron deficiency. J Pediatr 1975; 86: 899-902.
7. MacDougall LG, Anderson R, McNab GM, Katz J. The immune response in iron deficient children: Impaired cellular defense mechanisms with altered humoral components. J Pediatr 1975; 86: 833-43.
8. Krantman HJ, Young SR, Ank BJ, O'Donell MC, Rachelefsky GS, Steihm RE. Immune function in pure iron deficiency. Am J Dis Child 1982; 136: 840-4.
9. Srikantia SG, Sivaprasad J, Bhaskaram C, Krishnamachari KAVR. Anemia and immune response. Lancet 1976; 3: 1307-9.
10. Kuvibidila S, Dardene M, Savino W, Lepault F. Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T cell subsets and thymocyte proliferation. Am J Clin Nutr 1990; 51: 228-32.
11. Van Heerden C, Oosthuizen R, VanWyk R, Prinsloo P, Anderson R. Evaluation of neutrophil and lymphocyte function in subjects with iron deficiency. SA Med J 1981; 89: 111-3.
12. Beger J, Dyck JL, Galan P, Aplogan A, Schneider D, Traissac P, et al. Effect of daily iron supplementation on iron status, cell mediated immunity and incidence of infections in 6 to 36 month old Togolese children. Eur J Clin Nutr 2001; 54: 29-31.
13. Walter T, Aredondo S, Arevalo M, Stekel A. Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron deficient infants. Am J Clin Nutr 1986; 44: 877-82.
14. Santos PC, Falcao RP. Decreased lymphocyte subsets and K cell activity in iron deficiency anemia. Acta Hematol 1990; 84: 118-21.
15. Zimmer JP, Garza C, Heller ME, Butte N, Goldman AS. Postpartum maternal blood helper T (CD 3+, CD4+) and cytotoxic (CD 3+ CD 8+) cells: correlations with iron status, parity, supplement use and lactational status. Am J Clin Nutr 1998; 67: 897-904.
16. Luraschi A, Borgotti P, Gioria A, Fedeli P. Determination of lymphocyte subpopulations, defined with monoclonal antibodies, in patients with iron deficiency anemia. Minerva Med 1991; 82: 557-63.
17. Berger J, Schneider D, Dyck JL, Joseph A, Aplogan A, Galan P, et al. Iron deficiency, cell mediated immunity and infection among 6-36 month old children living in rural Togo. Nutr Res 1992; 12: 39-49.
18. Thibault H, Galan P, Selz F, Preziosi P, Olivier C, Badoul J, et al. The immune response in iron deficient young children: effect of iron supplementation on cell mediated immunity. Eur J Pediatr 1993; 152: 120-4.
19. Ghai OP. Essential pediatrics. 5th ed. New Delhi: Interprint; 2001.
20. Perkins LS. Wintrobe's clinical hematology. 10th ed. USA. Lippincott: Williams and Wilkins; 2001 p. 10-2.
21. Lewis SM, Bain BJ, Bates I. Practical hematology, 9th ed. London: Churchill Livingstone; 2001.
22. Marti GE, Stetler-Stevenson M, Bleesing JJH, Fleisher TA. Introduction to flow cytometry. Sem Hematol 2001; 38: 93-9.
23. Kind CRH, Pepys MB. The role of C-reactive protein (CRP) measurement in clinical practice. Int Med 1984; 5: 112-51.
24. Kemhali AS, Babacan E, Cavdar AO. Cell mediated immune responses in children with iron deficiency and children with combined iron and zinc deficiency. Nutr Res 1988; 8: 129-36.