Autoimmune pancreatitis with extreme elevation of DUPAN-2

Internal Medicine

Volumn 46, Issue 7, 2007, Pages 377-381

  Mishima, Shiho ^a,b   Mizuta, Yohei ^b   Yamao, Takuji ^a   Yamakawa, Masaki ^a   Akazawa, Yuko ^b   Mishima, Ryosuke ^b   Ohba, Kazuo ^b   Masuda, Jun Ich ^b   Ohnita, Ken ^b   Isomoto, Hajime ^b   Shikuwa, Saburo ^b   Omagari, Katsuhisa ^b   Kohno, Shigeru ^b  

^a Nagasaki Municipal Hospital   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoimmune pancreatitis; DUPAN 2; IgG4; Steroid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMYLASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DUPAN 2; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN A1C; IMMUNOGLOBULIN G4; LACTATE DEHYDROGENASE; PREDNISOLONE; RHEUMATOID FACTOR;

AGED; ARTICLE; AUTOIMMUNE PANCREATITIS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FEMALE; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; IMMUNOGLOBULIN BLOOD LEVEL; JAUNDICE; LIVER DYSFUNCTION; MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY; PANCREAS DUCT STENOSIS; SWELLING;

ACUTE DISEASE; ADRENAL CORTEX HORMONES; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; PANCREATIC FUNCTION TESTS; PANCREATIC NEOPLASMS; PANCREATITIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 34247162324     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6184     Document Type: Article

References (26)

1. Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 40: 1561-1568, 1995.
2. Deshpande V, Mino-Kenudson K Brugge W, Lauwers GY Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology. Arch Pathol Lab Med 129: 1148-1154, 2005.
3. Kamisawa T, Egawa N, Nakajima H, Tsuruta K, Okamoto A, Kamata N. Clinical difficulties in the differentiation of autoimmune pancreatitis and pancreatic carcinoma. Am J Gastroenterol 98: 2694-2699, 2003.
4. Ueda M, Watanabe T, Marui K, et al. A case of pancreatiti showing diffuse irregular narrowing of the main pancreatic duct on ERCP with elevation of CA19-9 and DUPAN-2. Gastroenterol Endosc 43: 1299-1305, 2001 (in Japanese).
5. Pezzilli R, Casadei R, Calculli L, Santini D. Autoimmune pancreatitis. A case mimicking carcinoma. J Pancreas 5: 527-530, 2004.
6. Ketikoglou I, Moulakakis A. Autoimmune pancreatitis. Dig Liver Dis 37: 211-215, 2005.
7. Okazaki K. Autoimmune pancreatitis: etiology, pathogenesis, clinical findings and treatment. The Japanese experience. J Pancreas 6: 89-96, 2005.
8. Okamoto R, Shimizu K, Nakagawa R, et al. Autoimmune pancreatitis with recurrent obstructive jaundice effectively treated with a steroid-report of a case. Endoscopic forum for digestive disease 20: 51-56, 2004 (in Japanese).
9. Kageyama F, Takehira Y, Yamada M, et al. A case report of Autoimmune pancreatitis with abnormal elevation of CA19-9 and Pathological findings. Nippon Shokakibyo Gakkai Zasshi 103: 57-63, 2006 (in Japanese).
10. Members of the Criteria Committee Autoimmune Pancreatitis of the Japan Pancreas Society. Diagnostic criteria for autoimmune pancreatitis by the Japan Pancreas Society. J Jpn Panc Soc 17: 585-587, 2002 (in Japanese).
11. Zamboni G, Luttges J, Capelli P, et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 445: 552-563, 2004.
12. Ohara H, Nakazawa T, Sano H, et al. Systemic extrapancreatic lesions associated with autoimmune pancreatitis. Pancreas 31: 232-237, 2005.
13. Yamamoto M, Ohara M, Suzuki C, et al. Elevated IgG4 concentrations in serum of patients with Mikulicz's disease. Scand J Rheumatol 33: 432-433, 2004.
14. Nishihara S, Narimatsu H, Iwasaki H, et al. Molecular genetic analysis of the human Lewis histo-blood group system. J Biol Chem 269: 29271-29278, 1994.
15. Yang DH, Kim KW, Kim TK, et al. Autoimmune pancreatitis: radiologic findings in 20 patients. Abdom Imaging 31: 94-102, 2006.
16. Koga Y, Yamaguchi K, Sugitani A, Chijiiwa K, Tanaka M. Autoimmune pancreatitis starting as a localized form. J Gastroenterol 37: 133-137, 2002.
17. Sahani DV, Kalva SP, Farrell J, et al. Autoimmune pancreatitis: imaging features. Radiology 233: 345-352, 2004.
18. Irie H, Honda H, Baba S, et al. Autoimmune pancreatitis. CT and MR characteristics. Am J Roentgenol 170: 1323-1327, 1998.
19. Procacci C, Carbognin G, Biasiutti C, et al. Autoimmune pancreatitis: possibilities of CT characterization. Pancreatology 1: 246-253, 2001.
20. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344: 732-738, 2001.
21. Suzuki Y, Ichihara T, Nakao A, Sakamoto J, Takagi H, Nagura H. High serum levels of DUPAN2 antigen and CA19-9 in pancreatic cancer: correlation with immunocytochemical localization of antigens in cancer cells. Hepatogastroenterol 35: 128-135, 1988.
22. Haviland AE, Borowitz MJ, Killenberg PG, Lan MS, Metzgar RS. Detection of an oncofetal antgen (DUPAN-2) in sera of patients with nonmalignant hepatobiliary diseases and hepatomas. Int J Cancer 41: 789-793, 1988.
23. Ohshio G, Manabe T, Watanabe Y, et al. Comparative studies of DU-PAN-2, carcinoembryonic antigen, and CA19-9 in the serum and bile of patients with pancreatic and biliary tract diseases: evaluation of the influence of obstructive jaundice. Am J Gastroenterol 85: 1370-1376, 1990.
24. Kawa S, Oguchi H, Kobayashi T, et al. Elevated serum levels of DUPAN-2 in pancreatic cancer patients negative for Lewis blood group phenotype. Br J Cancer 64: 899-902, 1991.
25. Hasebe O. Study on mechanism of serum elevation of pancreatic cancer-associated carbohydrate antigens (CA19-9, CA50, sialy1 SSEA-1, Span-1 and DUPAN-2) in chronic pancreatitis patient. J Jpn Panc Soc 6: 31-46, 1991 (in Japanese).
26. Kawa S, Tokoo M, Oguchi H, et al. Epitope analysis of Span-1 and DUPAN-2 using synthesized glycoconjugates sialyllact-N-fucopentaose II and sialyllact-N-tetraose. Pancreas 9: 692-697, 1994.