High Radiation Dose May Reduce the Negative Effect of Large Gross Tumor Volume in Patients With Medically Inoperable Early-Stage Non-Small Cell Lung Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 68, Issue 1, 2007, Pages 103-110

  Zhao, Lujun ^a   Hayman, James A ^a   Lyons, Susan ^b   Cease, Kemp ^b  

^a Spring)   (United States)

^b Spring)   (United States)

Author keywords

Dose; Gross tumor volume; Non small cell lung cancer

Indexed keywords

DOSIMETRY; MATHEMATICAL MODELS; RADIOTHERAPY; REGRESSION ANALYSIS; THREE DIMENSIONAL; TUMORS;

GROSS TUMOR VOLUME; HIGH-DOSE RADIATION; MULTIVARIATE ANALYSIS; NON-SMALL CELL LUNG CANCER;

ONCOLOGY;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; COMPUTER ASSISTED RADIOTHERAPY; FEMALE; HUMAN; KAPLAN MEIER METHOD; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; RADIATION DOSE; REGRESSION ANALYSIS; THREE DIMENSIONAL CONFORMAL RADIOTHERAPY; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, CONFORMAL; RELATIVE BIOLOGICAL EFFECTIVENESS; RETROSPECTIVE STUDIES;

EID: 34247158567     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.11.051     Document Type: Article

References (23)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2006. CA Cancer J Clin 56 (2006) 106-130
2. McGarry R.C., Song G., des Rosiers P., et al. Observation-only management of early stage, medically inoperable lung cancer: Poor outcome. Chest 121 (2002) 1155-1158
3. Wisnivesky J.P., Bonomi M., Henschke C., et al. Radiation therapy for the treatment of unresected stage I/II non-small cell lung cancer. Chest 128 (2005) 1461-1467
4. Kong F.M., Zhao L., and Hayman J.A. The role of radiation therapy in thoracic tumors. Hematol Oncol Clin North Am 20 (2006) 363-400
5. Perez C.A., Stanley K., Rubin P., et al. A prospective randomized study of various radiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Preliminary report by the Radiation Therapy Oncology Group. Cancer 45 (1980) 2744-2753
6. Kupelian P.A., Komaki R., and Allen P. Prognostic factors in the treatment of node-negative nonsmall cell lung carcinoma with radiotherapy alone. Int J Radiat Oncol Biol Phys 36 (1996) 607-613
7. Sibley G.S., Jamieson T.A., Marks L.B., et al. Radiotherapy alone for medically inoperable Stage I non-small-cell lung cancer: The Duke experience. Int J Radiat Oncol Biol Phys 40 (1998) 149-154
8. Rengan R., Rosenzweig K.E., Venkatraman E., et al. Improved local control with higher doses of radiation in large-volume Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 60 (2004) 741-747
9. Rosenzweig K.E., Fox J.L., Yorke E., et al. Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma. Cancer 103 (2005) 2118-2127
10. Kong F.M., Ten Haken R.K., Schipper M.J., et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 63 (2005) 324-333
11. Chen M., Hayman J.A., Ten Haken R.K., et al. Long-term results of high-dose conformal radiotherapy for patients with medically inoperable T1-3N0 non-small-cell lung cancer: Is low incidence of regional failure due to incidental nodal radiation?. Int J Radiat Oncol Biol Phys 64 (2006) 120-126
12. Mery C.M., Pappas A.N., Burt B.M., et al. Diameter of non-small cell lung cancer correlates with long-term survival: Implications for T stage. Chest 128 (2005) 3255-3260
13. Basaki K., Abe Y., Aoki M., et al. Prognostic factors for survival in stage III non-small-cell lung cancer treated with definitive radiation therapy: Impact of tumor volume. Int J Radiat Oncol Biol Phys 64 (2006) 449-454
14. Bradley J.D., Ieumwananonthachai N., Purdy J.A., et al. Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 52 (2002) 49-57
15. De Petris L., Lax I., Sirzen F., et al. Role of gross tumor volume on outcome and of dose parameters on toxicity of patients undergoing chemoradiotherapy for locally advanced non-small cell lung cancer. Med Oncol 22 (2005) 375-381
16. Etiz D., Marks L.B., Zhou S.M., et al. Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 53 (2002) 835-846
17. Willner J., Baier K., Caragiani E., et al. Dose, volume, and tumor control prediction in primary radiotherapy of non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 52 (2002) 382-389
18. Martel M.K., Strawderman M., Hazuka M.B., et al. Volume and dose parameters for survival of non-small cell lung cancer patients. Radiother Oncol 44 (1997) 23-29
19. Stinchcombe T.E., Morris D.E., Moore D.T., et al. Post-chemotherapy gross tumor volume is predictive of survival in patients with stage III non-small cell lung cancer treated with combined modality therapy. Lung Cancer 52 (2006) 67-74
20. Onishi H., Araki T., Shirato H., et al. Stereotactic hypofractionated high-dose Radiation for stage I nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 101 (2004) 1623-1631
21. Nyman J., Johansson K.A., and Hulten U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer-mature results for medically inoperable patients. Lung Cancer 51 (2006) 97-103
22. Fletcher G.H. The evolution of the basic concepts underlying the practice of radiotherapy from 1949 to 1977. Radiology 127 (1978) 3-19
23. Khalil A.A., Bentzen S.M., and Overgaard J. Steepness of the dose-response curve as a function of volume in an experimental tumor irradiated under ambient or hypoxic conditions. Int J Radiat Oncol Boil Phys 39 (1997) 797-802