Esophageal smooth muscle reactivity is impaired in chronic reflux esophagitis by both receptor- and nonreceptor-mediated mechanisms

Journal of Pediatric Surgery

Volumn 42, Issue 4, 2007, Pages 641-646

  Tugtepe, Halil ^a   Tugay, Melih ^b   Bozkurt, Süheyla ^a   Yildiz, Firuzan ^b   Utkan, Tijen ^b   Yegen, Berrak C ^a   Dagli, Tolga E ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b KOCAELI UNIVERSITY   (Turkey)

Author keywords

Carbachol; Esophagus; Gastroesophageal reflux; In vitro; Serotonin; Smooth muscle

Indexed keywords

CARBACHOL; PAPAVERINE; POTASSIUM CHLORIDE; SEROTONIN CREATININE SULFATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESOPHAGUS MOTILITY; ESOPHAGUS MUSCLE; GASTROESOPHAGEAL REFLUX; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REFLUX ESOPHAGITIS; SMOOTH MUSCLE CONTRACTION;

ANIMALS; CALCIUM CHANNELS; CARBACHOL; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGITIS, PEPTIC; ESOPHAGUS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PAPAVERINE; PERISTALSIS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLINERGIC; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 34247152562     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2006.12.048     Document Type: Article

References (20)

1. Somani S.K., Ghoshal U.C., Saraswat V.A., et al. Correlation of esophageal pH and motor abnormalities with endoscopic severity of reflux esophagitis. Dis Esophagus 17 (2004) 58-62
2. Fouad Y.M., Katz P.O., Hatlebakk J.G., et al. Ineffective esophageal motility: the most common motility abnormality in patients with GERD-associated respiratory symptoms. Am J Gastroenterol 94 6 (1999) 1464-1467
3. Gill R.C., Bowes K.L., Murphy P.D., et al. Esophageal motor abnormalities in gastroesophageal reflux and the effects of fundoplication. Gastroenterology 91 (1986) 364-369
4. Kahrilas P.J., Dodds W.J., Hogan W.J., et al. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 91 (1986) 897-904
5. Fibbe C., Layer P., Keller J., et al. Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology 121 (2001) 5-14
6. Bumm R., Feussner H., Holscher A.H., et al. Interaction of gastroesophageal reflux and esophageal motility. Evaluation by ambulatory 24-hour manometry and pH-metry. Dig Dis Sci 37 (1992) 1192-1199
7. Tugay M., Yi{dotless}ldi{dotless}z F., Utkan T., et al. Esophagitis impairs esophageal smooth muscle reactivity in the rat model: an in vitro study. Dig Dis Sci 48 (2003) 2147-2152
8. Omura N., Kashiwagi H., and Aoki T. Changes in gastric hormones associated with gastric outlet obstruction. An experimental study in rats. Scand J Gastroenterol 28 (1993) 568-572
9. Baxter G.S., Craig D.A., and Clarke D.E. 5-hydroxytriptamine receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg's Arch Pharmacol 343 (1991) 439-446
10. Omari T., Barnett C., Snel A., et al. Mechanism of gastroesophageal reflux in premature infants with chronic lung disease. J Pediatr Surg 34 (1999) 1795-1798
11. Bumm R., Feussner H., Holscher A.H., et al. Interaction of gastroesophageal reflux and esophageal motility. Evaluation by ambulatory 24-hour manometry and pH-metry. Dig Dis Sci 37 (1992) 1192-1199
12. Godoy J., Tovar J.A., Vicente Y., et al. Esophageal motor dysfunction persists in children after surgical cure of reflux: an ambulatory manometric study. J Pediatr Surg 36 (2001) 1405-1411
13. Kaul B., Petersen H., Grette K., et al. Scintigraphy, pH measurement, and radiography in the evaluation of gastroesophageal reflux. Scand J Gastroenterol 20 (1985) 289-294
14. Kahrilas P.J., Dodds W.J., Hogan W.J., et al. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology 91 (1986) 897-904
15. Kruse-Andersen S., Wallin L., and Madsen T. Reflux patterns and related esophageal motor activity in gastroesophageal reflux disease. Gut 31 (1990) 633-638
16. Chitkara D.K., Fortunato C., and Nurko S. Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis. J Pediatr Gastroenterol Nutr 40 1 (2005) 70-75
17. Sohn U.D., Harnett K.M., De Petris G., et al. Distinct muscarinic receptors, G-proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle. J Pharmacol Exp Ther 267 (1993) 1205-1214
18. Harnett K.M., Cao W., Kim N., et al. Signal transduction in esophageal and LES circular muscle contraction. Yale J Biol Med 72 (1999) 153-168
19. Palmer J.M., Weisbrodt N.W., and Castro G.A. Trichinella spiralis: intestinal myoelectrical activity during enteric infection in the rat. Exp Parasitol 57 (1984) 132-141
20. Moummi C., Yang D.C., and Gullikson G.W. 5HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus. EJ Pharmacol 216 (1992) 47-52