The CHRNE 470del20 mutation causing congenital myasthenic syndrome in South African Brahman cattle: Prevalence, origin, and association with performance traits

Journal of Animal Science

Volumn 85, Issue 3, 2007, Pages 604-609

  Thompson, P N ^a   Van Der Werf, J H J ^b   Heesterbeek, J A P ^c   Van Arendonk, J A M ^d  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

^c UTRECHT UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Brahman cattle; Congenital myasthenic syndrome; Genotyping; Heterozygote; Pedigree analysis

Indexed keywords

ANIMALIA; BOS; HUMAN HERPESVIRUS 4;

ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CATTLE DISEASE; CONGENITAL MYASTHENIC SYNDROME; FEMALE; GENETICS; GENOTYPE; HETEROZYGOTE; MALE; MUTATION; PREVALENCE; SOUTH AFRICA;

ANIMALS; CATTLE; CATTLE DISEASES; FEMALE; GENOTYPE; HETEROZYGOTE; MALE; MUTATION; MYASTHENIC SYNDROMES, CONGENITAL; PREVALENCE; SOUTH AFRICA;

EID: 34247149911     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2006-379     Document Type: Article

References (18)

1. Davis, G. P. 1993. Genetic parameters for tropical beef cattle in Northern Australia: A review. Aust. J. Agric, Res. 44:179-198.
2. Gilmour, A. R., B. J. Gogel, B. R. Cullis, S. J. Welham, and R. Thompson. 2002. ASReml User Guide Release 1.0. VSN Int. Ltd., Hemel Hempstead, UK.
3. Hedrick, P. W. 2000. Genetics of Populations. Jones & Bartlett Publishers, Sudbury, MA.
4. Henderson, C. R. 1984. Applications of Linear Models in Animal Breeding. University of Guelph, Guelph, Ontario, Canada.
5. Kennedy, B. W., M. Quinton, and J. A. van Arendonk. 1992. Estimation of effects of single genes on quantitative traits. J. Anim. Sci. 70:2000-2012.
6. Kerr, R. J., and B. P. Kinghorn. 1996. An efficient algorithm for segregation analysis in large populations. J. Anim. Breed. Genet. 113:457-469.
7. Kinghorn, B. P. 1994. Pedigree Viewer-A graphical utility for browsing pedigreed data sets. Proc. 5th World Congr. Genet. Appl. Livest. Prod., Guelph, Ontario, Canada 22:85-86.
8. Kneeland, J., C. Li, J. Basarab, W. M. Snelling, B. Benkel, B. Murdoch, C. Hansen, and S. S. Moore. 2004. Identification and fine mapping of quantitative trait loci for growth traits on bovine chromosomes 2, 6, 14, 19, 21, and 23 within one commercial line of Bos taurus. J. Anim. Sci. 82:3405-3414.
9. Kraner, S., J. P. Sieb, P. N. Thompson, and O. K. Steinlein. 2002. Congenital myasthenia in Brahman calves caused by homozygosity for a CHRNE truncating mutation. Neurogenetics 4:87-91.
10. Krishnamoorthy, K. 2000. Statistical distributions with applications and StatCalc software. Etext.net, Venice, CA.
11. Porter, V. 1991. Cattle: A Handbook to the Breeds of the World. Christopher Helm, London, UK.
12. Taylor, J. F., L. L. Coutinho, K. L. Herring, D. S. Gallagher, Jr., R. A. Brenneman, N. Burney, J. O. Sanders, J. W. Turner, S. B. Smith, R. K. Miller, J. W. Savell, and S. K. Davis. 1998. Candidate gene analysis of GH1 for effects on growth and carcass composition of cattle. Anim. Genet. 29:194-201.
13. Thompson, P. N. 1998. Suspected congenital myasthenia gravis in Brahman calves. Vet. Rec. 143:526-529.
14. Thompson, P. N., J. A. Dennis, K. N. Mercieca, C. K. Harper, and A. J. Guthrie. 2003a. Screening for two genetic diseases affecting calf survival in South African and Australian Brahman cattle. Proc. Xth Int. Symp. Vet. Epidemiol. Econ., Viña del Mar, Chile.
15. Thompson, P. N., J. A. P. Heesterbeek, and J. A. M. Van Arendonk. 2006. Changes in disease gene frequency over time with differential genotypic fitness and various control strategies. J. Anim. Sci. 84:2629-2635.
16. Thompson, P. N., O. K. Steinlein, C. K. Harper, S. Kraner, J. P. Sieb, and A. J. Guthrie. 2003b. Congenital myasthenic syndrome of Brahman cattle in South Africa. Vet. Rec. 153:779-781.
17. USDA-ARS. 2006. Meat Animal Research Center Cattle Genome Linkage Map, http://www.marc.usda.gov/genome/cattle/cattle.html Accessed May 18, 2006.
18. Weller, J. I., M. Golik, E. Seroussi, E. Ezra, and M. Ron. 2003. Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J. Dairy Sci. 86:2219-2227.