Antibiotic cement-coated interlocking nail for the treatment of infected nonunions and segmental bone defects

Journal of Orthopaedic Trauma

Volumn 21, Issue 4, 2007, Pages 258-268

  Thonse, Raghuram ^a   Conway, Janet ^b  

^a MUSGRAVE PARK HOSPITAL   (United Kingdom)

^b SINAI HOSPITAL OF BALTIMORE   (United States)

Author keywords

Antibiotics; Cement; Infection; Intramedullary nail; Nonunion

Indexed keywords

ANTIBIOTIC AGENT; BONE CEMENT;

ABOVE KNEE AMPUTATION; ACINETOBACTER; ADOLESCENT; ADULT; AGED; ARTHRODESIS; ARTICLE; BONE DEFECT; BONE INFECTION; BONE NAIL; CLINICAL ARTICLE; DEBRIDEMENT; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; EXTERNAL FIXATOR; FEMALE; FRACTURE EXTERNAL FIXATION; FRACTURE FIXATION; FRACTURE NONUNION; HUMAN; INFECTION CONTROL; INTERLOCKING NAIL; INTRAMEDULLARY NAIL; INTRAMEDULLARY NAILING; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; PROSTHESIS INFECTION; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; SURGICAL TECHNIQUE;

ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; BONE CEMENTS; BONE NAILS; CHRONIC DISEASE; COATED MATERIALS, BIOCOMPATIBLE; FEMALE; FOLLOW-UP STUDIES; FRACTURE FIXATION, INTRAMEDULLARY; FRACTURES, UNUNITED; HUMANS; MALE; MIDDLE AGED; OSTEOMYELITIS; PROSTHESIS DESIGN; RETROSPECTIVE STUDIES; TIBIA; TIBIAL FRACTURES; TREATMENT OUTCOME;

EID: 34247136733     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31803ea9e6     Document Type: Article

References (30)

1. Patzakis MJ, Zalavras CG. Chronic posttraumatic osteomyelitis and infected nonunion of the tibia: current management concepts. J Am Acad Orthop Surg. 2005;13:417-427.
2. Beals RK, Bryant RE. The treatment of chronic open osteomyelitis of the tibia in adults. Clin Orthop Relat Res. 2005;433:212-217.
3. Zalavras CG, Patzakis MJ, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res. 2004;427:86-93.
4. Henry SL, Ostermann PA, Seligson D. The prophylactic use of antibiotic impregnated beads in open fractures. J Trauma. 1990;30:1231-1238.
5. D. Paley D. Radiographic assessment of lower limb deformities. In: Paley D, ed. Principles of Deformity Correction. Berlin, Germany: Springer-Verlag; 2003:31-60.
6. Cierny III G, Mader JR, Penninck JJ. A clinical staging system for adult osteomyelitis. Contemp Orthop. 1985;10:17-37.
7. Hanssen AD. Local antibiotic delivery vehicles in the treatment of musculoskeletal infection. Clin Orthop Relat Res. 2005;437:91-96.
8. Hendricks KJ, Lane D, Burd TA, et al. Elution characteristics of tobramycin from polycaprolactone in a rabbit model. Clin Orthop Relat Res. 2001;392:418-426.
9. Rutledge B, Huyette D, Day D, et al. Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clin Orthop Relat Res. 2003;411:280-287.
10. Gürsel I, Korkusuz F, Türesin F, et al. In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials. 2001;22:73-80.
11. Shirtliff ME, Calhoun JH, Mader JT. Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite. Clin Orthop Relat Res. 2002;401:239-247.
12. Mader JT, Stevens CM, Stevens JH, et al. Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant. Clin Orthop Relat Res. 220;403:58-72.
13. Ambrose CG, Clyburn TA, Louden K, et al. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin Orthop Relat Res. 2004;421:293-299.
14. Türesïn F, Gürsel İ, Hasirci V. Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release. J Biomater Sci Polymer Edn. 2001;12:195-207.
15. van Raaij TM, Visser LE, Vulto AG, et al. Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty. J Arthroplasty. 2002;17:948-950.
16. Hanssen AD. Prophylactic use of antibiotic bone cement: an emerging standard: in opposition. J Arthroplasty. 2004;19:73-77.
17. Nelson CL, Griffin FM, Harrison BH, et al. In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads. Clin Orthop Relat Res. 1992;284:303-309.
18. Wahlig H, Dingeldein E, Bergmann R, et al. The release of gentamicin from polymethylmethacrylate beads: an experimental and pharmacokinetic study. J Bone Joint Surg Br. 1978;60:270-275.
19. Perry AC, Prpa B, Rouse MS, et al. Levofloxacin and trovafloxacin inhibition of experimental fracture healing. Clin Orthop Relat Res. 2003;414:95-100.
20. Lindsey RW, Probe R, Miclau T, et al. The effects of antibiotic- impregnated autogenic cancellous bone graft on bone healing. Clin Orthop Relat Res. 1993;291:303-312.
21. Tandon SC, Thomas PB. Persistent osteomyelitis of the femur: 2 cases of exchange intramedullary nailing with gentamicin beads in the nail. Acta Orthop Scand. 1996;67:620-622.
22. Sundgren K. Cemented modular intramedullary nail in failed knee arthroplasty: a report of 2 cases. Acta Orthop Scand. 1999;70:305-307.
23. Paley D, Herzenberg JE. Intramedullary infections treated with antibiotic cement rods: preliminary results in nine cases. J Orthop Trauma. 2002;16:723-729.
24. Ohtsuka H, Yokoyama K, Higashi K, et al. Use of antibiotic-impregnated bone cement nail to treat septic nonunion after tibial fracture. J Trauma. 2002;52:364-366.
25. Grimer RJ, Belthur M, Chandrasekar C, et al. Two-stage revision for infected endoprostheses used in tumor surgery. Clin Orthop Relat Res. 2002;395:193-203.
26. Bose WJ, Gearen PF, Randall JC, et al. Long-term outcome of 42 knees with chronic infection after total knee arthroplasty. Clin Orthop Relat Res. 1995;319:285-296.
27. Eldridge JC, Bell DF. Problems with substantial limb lengthening. Orthop Clin North Am. 191;22:625-631.
28. Green SA. Complications of external skeletal fixation. Clin Orthop Relat Res. 1983;180:109-116.
29. Herzenberg JE, Scheufele LL, Paley D, et al. Knee range of motion in isolated femoral lengthening. Clin Orthop Relat Res. 1994;301:49-54.
30. Paley D. Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop Relat Res. 1990;250:81-104.