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Intensive care unit syndrome/delirium is associated with anaemia, drug therapy and duration of ventilation
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Granberg Axell AIR, Malmros CW, Bergbom IL, Lundberg DBA. Intensive care unit syndrome/delirium is associated with anaemia, drug therapy and duration of ventilation. Acta Anaesthesiol Scand 2002; 46:726-731.
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7
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8
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Is dopamine administration possibly a risk factor for delirium?
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Evaluation of delirium in critically ill patients: Validation of the confusion assessment method for the intensive care unit (CAM-ICU)
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Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: Validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med 2001; 29:1370-1379.
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Ely, E.W.1
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Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002; 30:119-141.
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11
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1842867052
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Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
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Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291:1753-1762.
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Ely, E.W.1
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Six-month neuropsychological outcome of medical intensive care unit patients
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Peterson JF, Pun BT, Dittus RS, et al. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc 2006; 54:479-484. Largest study to date that helpfully describes the forms of delirium we can expect top see. Reminds us that in the elderly the hypoactive form is much more common and with the increasing numbers of elderly being admitted to the ICU the incidence will only increase.
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Peterson JF, Pun BT, Dittus RS, et al. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc 2006; 54:479-484. Largest study to date that helpfully describes the forms of delirium we can expect top see. Reminds us that in the elderly the hypoactive form is much more common and with the increasing numbers of elderly being admitted to the ICU the incidence will only increase.
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14
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0038142852
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Monitoring sedation status over time in ICU patients. Reliability and validity of the Richmond Agitation Sedation Scale (RASS)
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Ely W, Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients. Reliability and validity of the Richmond Agitation Sedation Scale (RASS). JAMA 2003; 289:2983-2991.
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Ely, W.1
Truman, B.2
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15
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Intensive care unit delirium is an independent predictor of long hospital stay: A prospective analysis of 261 nonventilated patients
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Thomason JWW, Shintani A, Peterson JF, et al. Intensive care unit delirium is an independent predictor of long hospital stay: a prospective analysis of 261 nonventilated patients. Crit Care 2005; 9:R375-R381.
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Thomason, J.W.W.1
Shintani, A.2
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16
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Giltray EJ, Huijskes RVHP, Kho KH, et al. Psychotic symptoms in patients undergoing coronary artery bypass grafting and heart valve operation. Eur J Cardiothorac Surg 2006; 30:140-147. Only focuses on those with overt psychotic symptoms; nevertheless, a large, interesting and detailed study
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Giltray EJ, Huijskes RVHP, Kho KH, et al. Psychotic symptoms in patients undergoing coronary artery bypass grafting and heart valve operation. Eur J Cardiothorac Surg 2006; 30:140-147. Only focuses on those with overt psychotic symptoms; nevertheless, a large, interesting and detailed study
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17
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10744222951
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Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
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Sharshar T, Gray F, Lorin de la Grandmaison G, et al. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003; 362:1799-1805.
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Sharshar, T.1
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Flacker, J.M.1
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19
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33644851831
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Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
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Raises the worrying concept that it is the very drugs that we use to sedate our patients that directly contribute to the delirium and brain dysfunction. That lorazepam was identified may merely reflect its frequent use in the patients studied and it may not be a unique villain
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Pandharipande P, Shintani A, Truman Pun B, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anaesthesiology 2006; 104:21-26. Raises the worrying concept that it is the very drugs that we use to sedate our patients that directly contribute to the delirium and brain dysfunction. That lorazepam was identified may merely reflect its frequent use in the patients studied and it may not be a unique villain.
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(2006)
Anaesthesiology
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Pandharipande, P.1
Shintani, A.2
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20
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Sedative and analgesic medications: Risk factors for delirium and sleep disturbances in the critically ill
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Pandharipande P, Ely EW. Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill. Crit Care Clin 2006; 22:313-327.
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Postoperative sedation and the incidence of ICU delirium in cardiac surgery patients [abstract]
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Maldonado JR, Van der Starre PJ, Wysong A. Postoperative sedation and the incidence of ICU delirium in cardiac surgery patients [abstract]. Anesthesiology 2003; 99:465.
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Maldonado, J.R.1
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22
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18344390321
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Dexmedetomidine does not improve patients' satisfaction when compared with propofol during mechanical ventilation
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Corbett SM, Rebuck JA, Greene CM, et al. Dexmedetomidine does not improve patients' satisfaction when compared with propofol during mechanical ventilation. Crit Care Med 2005; 33:940-945.
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Corbett, S.M.1
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34247156843
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Borthwick M, Bourne R, Craig M, et al. Detection, prevention and treatment of delirium in the critically ill patient. London: UK Clinical Pharmacy Association; 2006. A thorough review of delirium with detailed help and advice based upon best current evidence and practice. There remain many areas of contention.
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Borthwick M, Bourne R, Craig M, et al. Detection, prevention and treatment of delirium in the critically ill patient. London: UK Clinical Pharmacy Association; 2006. A thorough review of delirium with detailed help and advice based upon best current evidence and practice. There remain many areas of contention.
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24
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12244306234
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Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients
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Milbrandt EB, Kersten A, Kong L, et al. Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med 2005; 33:226-229.
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Milbrandt, E.B.1
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26
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Neurophysiological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome
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Hopkins RO, Weaver LK, Pope D, et al. Neurophysiological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 1999; 160:50-56.
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Hopkins, R.O.1
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27
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Seaman JS, Schillerstrom J, Carroll D, Brown TM. Impaired oxidative metabolism precipitates delirium: a study of 101 ICU patients. Psychosomatics 2006; 47:56-61. A study showing the association between markers of poor oxygen delivery (low haemoglobin, haematocrit and pulse oximetry) and delirium.
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Seaman JS, Schillerstrom J, Carroll D, Brown TM. Impaired oxidative metabolism precipitates delirium: a study of 101 ICU patients. Psychosomatics 2006; 47:56-61. A study showing the association between markers of poor oxygen delivery (low haemoglobin, haematocrit and pulse oximetry) and delirium.
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28
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33646884411
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Jones C, Griffiths RD, Slater T, et al. Significant cognitive dysfunction in nondelirious patients identified during and persisting following critical illness. Intensive Care Med 2006; 32:923-926. Detailed testing using touch-screen computer software showing severe cognitive dysfunction in awake nonsedated patients ventilated through tracheostomies who were not delirious at the time of testing although most likely had been delirious at some stage since many had to be excluded from study due to ongoing delirium
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Jones C, Griffiths RD, Slater T, et al. Significant cognitive dysfunction in nondelirious patients identified during and persisting following critical illness. Intensive Care Med 2006; 32:923-926. Detailed testing using touch-screen computer software showing severe cognitive dysfunction in awake nonsedated patients ventilated through tracheostomies who were not delirious at the time of testing (although most likely had been delirious at some stage since many had to be excluded from study due to ongoing delirium).
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33646148479
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Liberson I, Abelson JL, Amdur RL, et al. Increased psychiatric morbidity after abdominal aortic surgery: risk factors for stress-related disorders. J Vasc Surg 2006; 43:929-934. Another study of 109 vascular surgery patients showing a high rate of psychiatric morbidity (32%).
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Liberson I, Abelson JL, Amdur RL, et al. Increased psychiatric morbidity after abdominal aortic surgery: risk factors for stress-related disorders. J Vasc Surg 2006; 43:929-934. Another study of 109 vascular surgery patients showing a high rate of psychiatric morbidity (32%).
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30
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33745959392
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Richter JC, Waydhas C, Pajonk F-G. Incidence of posttraumatic stress disorder after prolonged surgical intensive care unit treatment. Psychosomatics 2006; 47:223-230. Small study (37 patients) in severe trauma patients, but unable to reach strong conclusions
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Richter JC, Waydhas C, Pajonk F-G. Incidence of posttraumatic stress disorder after prolonged surgical intensive care unit treatment. Psychosomatics 2006; 47:223-230. Small study (37 patients) in severe trauma patients, but unable to reach strong conclusions
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31
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0035107464
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Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care
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Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med 2001; 29:573-580.
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Jones, C.1
Griffiths, R.D.2
Humphris, G.3
Skirrow, P.M.4
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32
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Posttraumatic stress disorderrelated symptoms after intensive care
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Capuzzo M, Valpondi V, Cingolani E, et al. Posttraumatic stress disorderrelated symptoms after intensive care. Minerva Anestesiol 2005; 71:167-179.
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33
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Jones C, Capuzzo M, Flaatten H, et al. Precipitants of post traumatic stress disorder following intensive care: a hypothesis-generating study of diversity in care. Intensive Care Med 2007 (in press).
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Risk of Posttraumatic stress symptoms in family members of intensive care unit patients
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Post-traumatic stress disorder-related symptoms in relatives of patients following intensive care
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The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health related quality of life in survivors
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The effect of stress doses of hydrocortisone during septic shock on post traumatic stress disorder in survivors
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Use of a personal diary written on the ICU during critical illness
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Bäckmann CG, Walther SM. Use of a personal diary written on the ICU during critical illness. Intensive Care Med 2001; 27:426-429.
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