Soluble Factors From LPS- and PHA-Activated PBMC Induce MAPK, Stat1 and Stat3 Phosphorylation in Primary Cultures of Human Term Placental Trophoblasts: Implications for Infection and Prematurity

Placenta

Volumn 28, Issue 5-6, 2007, Pages 538-542

  Jiang, K ^a   Chen, Y ^a   Jarvis, J N ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Inflammation; Signaling transduction; Trophoblasts

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHYTOHEMAGGLUTININ; STAT1 PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL LYSATE; CELL NUCLEUS; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENZYME INDUCTION; FETOPLACENTAL UNIT; HUMAN; HUMAN CELL; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; PERIPHERAL BLOOD MONONUCLEAR CELL; PLACENTA; PREGNANCY; PREMATURITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TIME; TROPHOBLAST; VAGINITIS; WESTERN BLOTTING;

ENZYME ACTIVATION; FEMALE; HUMANS; KINETICS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHYTOHEMAGGLUTININS; PLACENTA; PREGNANCY; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TROPHOBLASTS;

EID: 34247117347     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2006.06.013     Document Type: Article

References (15)

1. Dudley D.J. Pre-term labor: an intra-uterine inflammatory response syndrome?. J Reproductive Immunol 36 (1997) 93-109
2. Makhseed M., Raghupathy R., El-Shazly S., Azizieh F., Al-Harmi J.A., and Al-Azemi M.M. Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol 49 (2003) 308-318
3. Gravett M.G., Hitti J., Hess D.L., and Eschenbach D.A. Intrauterine infection and preterm delivery: evidence for activation of the fetal hypothalamic-pituitary-adrenal axis. Am J Obstetr Gynecol 182 (2000) 1404-1413
4. Jarvis J.N., Dozmorov I., Jiang K., Chen Y., Frank M.B., Turner S., et al. Gene expression arrays demonstrate rapid return to normal homeostasis in immunologically-challenged of trophoblast-like JAR cells. J Reprod Immunol 61 (2004) 99-113
5. Jarvis J.N., Deng L., Berry S., Romero R., and Moore H. Fetal cytokine expression in utero detected by reverse transcriptase polymerase chain reaction. Pediatr Res 37 (1995) 450-454
6. Ghidini A. Activation of the fetal immune system: marker of imminent delivery or of intrauterine infection?. Am J Obstetr Gynecol 175 (1996) 501-502
7. Jiang K., Chen Y., and Jarvis J.N. Activated peripheral blood mononuclear cells induce p44/42 mitogen-activated protein kinase phosphorylation in trophoblast-like JAR cells. J Reprod Immunol 60 (2003) 113-128
8. Yui J., Garcia-Lloret M., Brown A.J., Berdan R.C., Morrish D.W., Wegmann T.G., et al. Functional, long-term cultures of human term trophoblasts purified by column-elimination of CD9 expressing cells. Placenta 15 (1994) 231-246
9. Knöfler M., Sooranna S.R., Daoud G., Whitely G.S., Markert U.R., Xia Y., et al. Trophoblast signaling: knowns and unknowns-a workshop report. Placenta 26 Suppl A (2005) S48-S51
10. Jiang K., Chen Y., and Jarvis J.N. HCG secretion in human choriocarcinoma Jar cells is MAPK but not Stat3 dependent: contributions of TNF alpha and IL-1-beta to inflammation-induced HCG secretion. Placenta 27 (2006) 853-860
11. Hanna N., Bonifacio L., Reddy P., Hannah I., Weinberger B., Murphy S., et al. IFN-γ-mediated inhibition of COX-2 expression in the placenta from term and preterm pregnancies. Am J Reprod Immunol 51 (2003) 311-318
12. Takeda K., Noguchi K., Shi W., Tanaka T., Matsumoto M., Yoshida N., et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci (USA) 94 (1997) 3801
13. Poehlmann T.G., Fitzgerald J.S., Meissner A., Wengenmayer T., Schleussner E., Friedrich K., et al. Trophoblast invasion: LIF signaling through Stat3. Placenta 26 (2005) S37-S41
14. Durbin J.E., Hackenmiller R., Simon M.C., and Levy D.E. Targeted disruption of the mouse Stat1 gene results in compromised immunity to viral disease. Cell 84 (1996) 443-450
15. Boehm U., Klamp T., Groot M., and Howard J.C. Cellular responses to interferon gamma. Adv Immunol 15 (1997) 749-795