Bacillus thuringiensis pulmonary infection: critical role for bacterial membrane-damaging toxins and host neutrophils

Microbes and Infection

Volumn 9, Issue 5, 2007, Pages 591-598

  Ghelardi, Emilia ^a   Celandroni, Francesco ^a   Salvetti, Sara ^a   Fiscarelli, Ersilia ^b   Senesi, Sonia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Bacillus thuringiensis; Bacterial membrane damaging toxins; Hemolysin BL; Isogenic B. thuringiensis mutants; Murine pulmonary infection; Neutropenic mice; Phospholipase

Indexed keywords

BACTERIAL TOXIN; CYCLOPHOSPHAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS THURINGIENSIS; BACTERIAL INFECTION; BACTERIAL MEMBRANE; BACTERIAL PNEUMONIA; BACTERIAL SPORE; BACTERIAL STRAIN; CASE REPORT; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE COURSE; FATALITY; FEMALE; HUMAN; INFECTION SENSITIVITY; INOCULATION; LETHAL DOSE; LUNG INFECTION; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SCHOOL CHILD;

ANIMALS; BACILLACEAE INFECTIONS; BACILLUS THURINGIENSIS; BACTERIAL TOXINS; CHILD; DISEASE MODELS, ANIMAL; FEMALE; HEMOLYSIN PROTEINS; HUMANS; LUNG DISEASES; MICE; MICE, INBRED BALB C; NEUTROPHILS; PHOSPHOLIPASE C;

ANIMALIA; BACILLI (CLASS); BACILLUS THURINGIENSIS; BACTERIA (MICROORGANISMS); MURINAE; MUS;

EID: 34247096001     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2007.02.001     Document Type: Article

References (30)

1. Helgason E., Caugant D.A., Olsen I., and Kolstø A.-B. Genetic structure of population of Bacillus cereus and Bacillus thuringiensis isolates associated with periodontitis and other human infections. J. Clin. Microbiol. 38 (2000) 1615-1622
2. Read T.D., Peterson S.N., Tourasse N., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Økstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstø A.-B., and Fraser C.M. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423 (2003) 81-86
3. Schnepf E., Crickmore N., Van Rie J., Lereclus D., Baum J., Feitelson J., Zeigler D.R., and Dean D.H. Bacillus thuringiensis and its pesticidal crystal proteins. Microbiol. Mol. Biol. Rev. 62 (1998) 775-806
4. Jackson S.G., Goodbrand R.B., Ahmed R., and Kasatiya S. Bacillus cereus and Bacillus thuringiensis isolated in a gastroenteritis outbreak investigation. Lett. Appl. Microbiol. 21 (1995) 103-105
5. Samples J.R., and Beuttner H. Corneal ulcer caused by a biological insecticide (Bacillus thuringiensis). Am. J. Ophthalmol. 95 (1983) 258-260
6. Damgaard P.H., Granum P.E., Bresciani J., Torregrossa M.V., Eilenberg J., and Valentino L. Characterization of Bacillus thuringiensis isolated from infections in burn wounds, FEMS Immunol. Med. Microbiol. 18 (1997) 47-53
7. Hernandez E., Ramisse F., Ducoureau J.-P., Cruel T., and Cavallo J.-D. Bacillus thuringiensis subsp. konkunian (serotype H34) superinfection: case report and experimental evidence of pathogenicity in immunosuppressed mice. J. Clin. Microbiol. 36 (1998) 2138-2139
8. Lövgren A., Carlson C.R., Eskils K., and Kølsto A.-B. Localization of putative virulence genes on a physical map of the Bacillus thuringiensis subsp. gelechiae chromosome. Curr. Microbiol. 37 (1998) 245-250
9. Agaisse H., Gominet M., Økstad O.A., Kølsto A.-B., and Lereclus D. PlcR is a pleiotropic regulator of extracellular virulence factor gene expression in Bacillus thuringiensis. Mol. Microbiol. 32 (1999) 1043-1053
10. Gaviria Rivera A.M., Granum P.E., and Priest F.G. Common occurrence of enterotoxin genes and enterotoxicity in Bacillus thuringiensis. FEMS Microbiol. Lett. 190 (2000) 151-155
11. Callegan M.C., Cochran D.C., Kane S.T., Gilmore M.S., Gominet M., and Lereclus D. Contribution of membrane-damaging toxins to Bacillus endophthalmitis pathogenesis. Infect. Immun. 70 (2002) 5381-5389
12. Callegan M.C., Kane S.T., Cochran D.C., Gilmore M.S., Gominet M., and Lereclus D. Relationship of plcR-regulated factors to Bacillus endophthalmitis virulence. Infect. Immun. 71 (2003) 3116-3124
13. Salamitou S., Ramisse F., Brehélin M., Bourguet D., Gilois N., Gominet M., Hernandez E., and Lereclus D. The plcR regulon is involved in the opportunistic properties of Bacillus thuringiensis and Bacillus cereus in mice and insects. Microbiology 146 (2000) 2825-2832
14. Lereclus D., Arantes O., Chaufaux J., and Lecadet M. Transformation and expression of a cloned delta-endotoxin gene in Bacillus thuringiensis. FEMS Microbiol. Lett. 15 (1989) 211-217
15. Gominet M., Slamti L., Gilois M., Rose M., and Lereclus D. Oligopeptide permease is required for expression of the Bacillus thuringiensis plcR regulon and for virulence. Mol. Microbiol. 40 (2001) 963-975
16. Ghelardi E., Celandroni F., Salvetti S., Beecher D.J., Gominet M., Lereclus D., Wong A.C.L., and Senesi S. Requirement of flhA for swarming differentiation, flagellin export, and secretion of virulence associated proteins in Bacillus thuringiensis. J. Bacteriol. 184 (2002) 6424-6433
17. Senesi S., Cercignani G., Freer G., Batoni G., Barnini S., and Ota F. Structural and stereospecific requirements for the nucleoside-triggered germination of Bacillus cereus spores. J. Gen. Microbiol. 137 (1991) 399-404
18. Ghelardi E., Celandroni F., Salvetti S., Barsotti C., Baggiani A., and Senesi S. Identification and characterization of Bacillus cereus isolates responsible for two food-poisoning outbreaks. FEMS Microbiol. Lett. 208 (2002) 129-134
19. Senesi S., Celandroni F., Tavanti A., and Ghelardi E. Molecular characterization and identification of Bacillus clausii strains marketed for use in oral bacteriotherapy. Appl. Environ. Microbiol. 67 (2001) 834-839
20. Beecher D.J., and Wong A.C.L. Identification of hemolysin BL-producing Bacillus cereus isolates by a discontinuous hemolytic pattern in blood agar. Appl. Environ. Microbiol. 60 (1994) 1646-1651
21. Finney D.J. In: Finney D.J. (Ed). Statistical Method in Biological Assay (1952), Charles Griffin & Company Limited, London 524-530
22. Beecher D.J., and Wong A.C.L. Improved purification and characterization of hemolysin BL: a hemolytic dermonecrotic vascular permeability factor from Bacillus cereus. Infect. Immun. 62 (1994) 980-986
23. Daugherty S., and Low M.G. Cloning, expression, and mutagenesis of phosphatidylinositol-specific phospholipase C from Staphylococcus aureus: a potential staphylococcal virulence factor. Infect. Immun. 61 (1993) 5078-5089
24. Schluter D., Domann E., Buck C., Hain T., Hof H., Chakraborty T., and Deckert-Schluter M. Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis. Infect. Immun. 66 (1998) 5930-5938
25. Sibelius U., Schulz E.C., Rose F., Hattar K., Jacobs T., Weiss S., Chakraborty T., Seeger W., and Grimminger F. Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils. Infect. Immun. 67 (1999) 1125-1130
26. Sanchis V., Gohar M., Chaufaux J., Arantes O., Meier A., Agaisse H., Cayley J., and Lereclus D. Development and field performance of a broad-spectrum nonviable asporogenic recombinant strain of Bacillus thuringiensis with greater potency and UV resistance. Appl. Environ. Microbiol. 65 (1999) 4032-4039
27. Gaur A.H., Patrick C.C., McCullers J.A., Flynn P.M., Pearson T.A., Razzouk B.I., Thompson S.J., and Shenep J.L. Bacillus cereus bacteremia and meningitis in immunocompromised children. Clin. Infect. Dis. 32 (2001) 1456-1462
28. Hilliard N.J., Schelonka R.L., and Waites K.B. Bacillus cereus bacteremia in a preterm neonate. J. Clin. Microbiol. 41 (2003) 3441-3444
29. Frankard J., Li R., Taccone F., Struelens M.J., Jacobs F., and Kentos A. Bacillus cereus pneumonia in a patient with acute lymphoblastic leukemia. Eur. J. Clin. Microbiol. Infect. Dis. 23 (2004) 725-728
30. Miller J.M., Hair J.G., Hebert M., Hebert L., Roberts F.J., and Weyant R.S. Fulminating bacteremia and pneumonia due to Bacillus cereus. J. Clin. Microbiol. 35 (1997) 504-507