Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries)

Journal of Animal Science

Volumn 85, Issue 3, 2007, Pages 598-603

  Chu, M X ^a   Liu, Z H ^b   Jiao, C L ^b   He, Y Q ^b   Fang, L ^a   Ye, S C ^a   Chen, G H ^b   Wang, J Y ^b  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

Bone morphogenetic protein 15 gene; Bone morphogenetic protein receptor ib gene; Prolificacy; Sheep

Indexed keywords

OVIS ARIES;

BONE MORPHOGENETIC PROTEIN RECEPTOR; GROWTH DIFFERENTIATION FACTOR 9; SIGNAL PEPTIDE;

ALLELE; ANIMAL; ARTICLE; CHINA; CLASSIFICATION; GENETICS; GENOTYPE; LITTER SIZE; MUTATION; PHYSIOLOGY; SHEEP; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS; CHINA; GENOTYPE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LITTER SIZE; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SHEEP;

EID: 34247093384     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2006-324     Document Type: Article

References (30)

1. Bodin, L., F. Lecerf, C. Pisselet, M. San Cristhal, M. Bibe, and P. Mulsant. 2003. How many mutations are associated with increased ovulation rate and litter size in progeny of Lacaune meat sheep? Pages 2-11 in Proc. Int. Workshop on Major Genes and QTL in Sheep and Goats. INRA, Toulouse, France.
2. I) are devoid of secondary and tertiary follicles but contain many abnormal structures. Biol. Reprod. 49;895-907.
3. Chu, M. X., R. Cheng, G. H. Chen, L. Fang, and S. C. Ye. 2005a. Study on bone morphogenetic protein 15 as a candidate gene for prolificacy of Small Tailed Han sheep and Hu sheep. J. Anhui Agric. Univ. 32:278-282.
4. Chu, M. X., L. H. Sang, J. Y. Wang, L. Fang, and S. C. Ye. 2005b. Study on BMP15 and GDF9 as candidate genes for prolificacy of Small Tailed Han sheep. Acta Genetica Sinica 32:38-45.
5. 1) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim. Reprod. Sci. 92:87-96.
6. Davis, G. H., K. G. Dodds, and G. D. Bruce. 1999. Combined effect of the Inverdale and Booroola prolificacy genes on ovulation rate in sheep. Proc. 13th Conf. Assoc. Adv. Anim. Breed, and Genet. 13:74-77.
7. Davis, G. H., S. M. Galloway, I. K. Ross, S. M. Gregan, J. Ward, B. V. Nimbkar, P. M. Ghalsasi, C. Nimbkar, G. D. Gray, Subandriyo, I. Inounu, B. Tiesnamurti, B. Martyniuk, E. Eythorsdottir, P. Mulsant, F. Lecerf, J. P. Hanrahan, G. E. Bradford, and T. Wilson. 2002. DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol. Reprod. 66:1869-1874.
8. Davis, G. H., J. C. McEwan, P. F. Fennessy, and K. G. Dodds. 1995. Discovery of the Inverdale gene (FecX). Proc. N. Z. Soc. Anim. Prod. 55:289-290.
9. I) for the Inverdale prolificacy gene located on the X chromosome. Biol. Reprod. 46:636-640.
10. Galloway, S. M., K. P. McNatty, L. M. Cambridge, M. P. E. Laitinen, J. L. Juengel, T. S. Jokiranta, R. J. McLaren, K. Luiro, K. G. Dodds, G. W. Montgomery, A. E. Beattie, G. H. Davis, and O. Ritvos. 2000. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dos-age-sensitive manner. Nat. Genet. 25:279-283.
11. Guan, F., S. R. Liu, G. Q. Shi, J. T. Ai, D. G. Mao, and L. G. Yang. 2006. Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Acta Genetica Sinica 33:117-124.
12. Hanrahan, J. P., S. M. Gregan, P. Mulsant, M. Mullen, G. H. Davis, R. Powell, and S. M. Galloway. 2004. Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol. Reprod. 70:900-909.
13. Jia, C. L., N. Li, X. B. Zhao, X. P. Zhu, and Z. H. Jia. 2005. Association of single nucleotide polymorphisms in exon 6 region of BMPRIB gene with litter size traits in sheep. Asian-Aust. J. Anim. Sci. 18:1375-1378.
14. Juengel, J. L., N. L. Hudson, D. A. Heath, P. Smith, K. L. Reader, S. B. Lawrence, A. R. O'Connell, M. P. Laitinen, M. Cranfield, N. P. Groome, O. Ritvos, and K. P. McNatty. 2002. Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. Biol. Reprod. 67:1777-1789.
15. Liu, S. F., Y. L. Jiang, and L. X. Du. 2003. Studies of BMPR-IB and BMP15 as candidate genes for fecundity in Little Tailed Han sheep. Acta Genetica Sinica 30:755-760.
16. Moore, R. K., F. Otsuka, and S. Shimasaki. 2003. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J. Biol. Chem. 278:304-310.
17. Moore, R. K., and S. Shimasaki. 2005. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol. Cell. Endocrinol. 234:67-73.
18. Mulsant, P., F. Lecerf, S. Fabre, L. Schibler, P. Monget, I. Lanneluc, C. Pisselet, J. Riquet, D. Monniaux, I. Callebaut, E. Cribiu, J. Thimonier, J. Teyssier, L. Bodin, Y. Cognie, N. Chitour, and J. M. Elsen. 2001. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Proc. Natl. Acad. Sci. USA 98:5104-5109.
19. Otsuka, F., and S. Shimasaki. 2002a. A negative feedback system between oocyte bone morphogenetic protein 15 and granulose cell kit ligand: Its role in regulating granulose cell mitosis. Proc. Natl. Acad. Sci. USA 99:8060-8065.
20. Otsuka, F., and S. Shimasaki. 2002b. A novel function of bone morphogenetic protein-15 in the pituitary:selective synthesis and secretion of FSH by gonadotropes. Endocrinology 143:4938-4941.
21. Otsuka, F., S. Yamamoto, G. F. Erickson, and S. Shimasaki. 2001. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. J. Biol. Chem. 276:11387-11392.
22. Otsuka, F., Z. Yao, T. Lee, S. Yamamoto, G. F. Erickson, and S. Shimasaki. 2000. Bone morphogenetic protein-15. Identification of target cells and biological functions. J. Biol. Chem. 275:39523-39528.
23. Souza, C. J. H., C. MacDougall, B. K. Campbell, A. S. McNeilly, and D. T. Baird. 2001. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type IB (BMPRIB) gene. J. Endocrinol. 169:R1-R6.
24. Tu, Y. R. 1989. Small Tailed Han sheep. Pages 50-52 in The Sheep and Goat Breeds in China. Shanghai Science and Technology Press, Shanghai, China.
25. Wang, J. Y., J. X. Li, and J. C. Wei. 1990. Selection and improvement on Small Tailed Han sheep. China Sheep and Goat Farming (1):1-3.
26. Wang, G. L., X. Z. Mao, G. H. Davis, Z. S. Zhao, L. J. Zhang, and Y. Q. Zeng. 2003a. DNA tests in Hu sheep and Han sheep (small tail) showed the existence of Booroola (FecB) mutation. J. Nanjing Agric. Univ. 26:104-106.
27. Wang, Q. G., F. G. Zhong, H. Li, X. H. Wang, S. R. Liu, and X. J. Chen. 2003b. The polymorphism of BMPR-IB gene associated with litter size in sheep. Grass-feeding Livest. (2):20-23.
28. Wang, Q. G., F. G. Zhong, H. Li, X. H. Wang, S. R. Liu, X. J. Chen, and S. Q. Gan. 2005. Detection on major gene on litter size in sheep. Heredites (Beijing) 27:80-84.
29. Wilson, T., X. Y. Wu, J. L. Juengel, I. K. Ross, J. M. Lumsden, E. A. Lord, K. G. Dodds, G. A. Walling, J. C. McEwan, A. R. O'Connell, K. P. McNatty, and G. W. Montgomery. 2001. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulose cells. Biol. Reprod. 64:1225-1235.
30. Yan, Y. D., M. X. Chu, Y. Q. Zeng, L. Fang, S. C. Ye, L. M. Wang, Q. K. Guo, D. Q. Han, Z. X. Zhang, X. J. Wang, and X. Z. Zhang. 2005. Study on bone morphogenetic protein receptor IB as a candidate gene for prolificacy in Small Tailed Han sheep and Hu sheep. J. Agric. Biotechnol. 13:66-71.