In vivo kinetics and biodistribution of HB-110, a novel HBV DNA vaccine, after administration in mice

Archives of Pharmacal Research

Volumn 30, Issue 3, 2007, Pages 355-360

  Eun, Sung Kang ^a   Chae, Young Kim ^a   Seon, Beom Kim ^a   Se, Jin Im ^b   Se, Hwan Yang ^b   Young, Chul Sung ^b   Byong, Moon Kim ^a  

^a Dong A Pharmaceutical Company   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Biodistribution; HB 110; HBV; In vivo kinetics; Plasmid DNA vaccine

Indexed keywords

EID: 34147220919     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02977618     Document Type: Article

References (21)

1. Aloman, C. and Wands, J. R., Resistance of HBV to adefovir dipivoxil: a case for combination antiviral therapy. Hepatology, 38, 1584-1587 (2003).
2. Angus, P., Vaughan, R., Xiong, S., Yang, H., Delaney, W., Gibbs, C., Brasgart, C., Colledge, D., Edwords, R., Ayres, A., Bartholomevsz, A., and Locarnini, S., Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase. Gastroenterology, 125, 292-297 (2003).
3. Boni, C., Penna, A., Ogg, G. S., Bertoletti, A., Pilli, M., Cavallo, C., Carvalli, A., Vrbani, S., Boehme, R., Panebianco, R., Fiaccardori, F., and Ferrari, C., Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology, 33, 963-971 (2001).
4. Boni, C., Penna, A., Bertoletti, A., Lamonaca, V., Rapti, I., Missale, G., Pilli, M., Vrbani, S., Caralli, A., Cerioni, S., Panebianco, R., Jerkins, J., and Ferrari, C., Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J. Hepatol., 39, 595-605 (2003).
5. Hengge, U. R., Dexling, B., and Mirmohammadsadegh, A., Safety and pharmacokinetics of naked plasmid DNA in the skin: studies on dissemination and ectopic expression. J. Invest. Dermatol., 116, 979-982 (2001).
6. Houk, B. E., Martin, R., Hochhaus, G., and Hughes, J.A., Kinetic Modeling of Plasmid DNA Degradation in Rat Plasma. AAPS Pharmsci., 1, article 9 (1999).
7. Kim, B. M., Lee, D. S., Choi, J. H., Kim, C. Y., Son, M., Suh, Y. S., Baek, K. H., Park, K. S., Sung, Y. C., and Kim, Y. B., In vivo kinetics and biodistribution of HIV DNA vaccine after administration in mice. Arch. Pharm. Res., 26, 493-498 (2003).
8. Ledwith, B. J., Manam, S., Troilo, P. J., Barnum, A. B., Pauley, C. J., Griffiths, T. G., Harper, L. B., Beare, C. M., Bagdon, W. J., and Nichols, W. W., Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in Mice. Intervirology, 43, 258-272 (2000).
9. Lee, W. M., Hepatitis B virus infection. N. Engl. J. Med., 337, 1733-1745 (1997).
10. Lew, D., Parker, S. E., Latimer, T., Abai, A. M., Kuwahara-Rundell, A., Doh, S. G., Seoun, G., Yang, Z. Y., Loface, D., and Stanislaw, H., Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum. Gene. Ther., 6, 553-564 (1995).
11. Liaw, Y. F., Leung, N. W., Chang, T. T., Guan, R., Tai, D. I., Ng, K. Y., Chien, R. H., Dent, J., Roman, L., Edmvndson, S., and Lai, C. L., Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology, 119, 172-180 (2000).
12. McClary, H., Koch, R., Chisari, F. V., and Guidotti, L. G., Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol., 74, 2255-2264 (2000).
13. Mancini-Bourgine, M., Fontaine, H., Brechot, C., Pol, S., and Michel, M. L., Immunogenecity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine, JVAC-5559-5566 (2005).
14. Michel, M. L. and Mancini-Bourgine, M., Therapeutic vaccination against chronic hepatitis B virus infection. Journal of Clinical Virology, 24 Suppl. 1 S108-S114 (2005).
15. Nishikawa, M., Takakura, Y., and Hashida, M., Theoretical considerations involving the pharmacokinetics of plasmid DNA. Advanced Drug Delivery Reviews, 57, 675-688 (2005).
16. Nishikawa, M., Takakura, Y., and Hashida, M., Pharmacokinetics of plasmid DNA-based non-viral gene medicine. Adv. Genet., 53, 47-68 (2005).
17. Peters, M., Vierling, J., Gershwin, M. E., Milich, D., Chisari, F. V., and Hoofnagle, J. H., Immunology and the liver. Hepatology, 13, 977-994 (1991).
18. Webster, G. J., Reignat, S., Brown, D., Ogg, G. S., Jones, L., Seneviratne, S. L., Suranjith, L., Williams, R., Duskeiko, G., and Bertoletti, A., Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J. Virol., 78, 5707-5719 (2004).
19. Wieland, S. F., Guidotti, L. G., and Chisari, F. V., Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J. Virol., 74, 4165-4173 (2000).
20. Yang, S. H., Lee, C. G., Park, S. H., Im, S. J., Kim, Y. M., Son, J. M., Wang, J. S., Yoon, S. K., Song, M. K., Ambrozaitis, A., Khargechenko, N., Yun, Y. D., Kim, C. M., Kim, C. Y., Lee, S. H., Kim, B. M., Kim, W. B., and Sung, Y. C., Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study. Gene Therapy, 1-8 (2006).
21. Zhang, H. Y., Sun, S. H., Guo, Y. J., Chen, Z. H., Huang, L., Gao, Y. J., Wan, B., Zhu, W. J., Xu, Z. X., and Wang, J. J., Tissue distribution of plasmid DNA containing epitopes of foot-and-mouth disease virus in mice. Vaccine, 23, 5632-5640 (2005).