Sexual symptoms in endocrine diseases: Psychosomatic perspectives

Psychotherapy and Psychosomatics

Volumn 76, Issue 3, 2007, Pages 134-140

  Balercia, Giancarlo ^a   Boscaro, Marco ^a   Lombardo, Francesco ^b   Carosa, Eleonora ^c   Lenzi, Andrea ^b   Jannini, Emmanuele A ^c,d  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Acromegaly; Female sexual behavior; Hypercortisolism; Hyperprolactinemia; Hyperthyroidism; Hypocortisolism; Hypogonadism; Hypothyroidism; Sexual dysfunction

Indexed keywords

ANDROGEN; GONADORELIN; GROWTH HORMONE; LUTEINIZING HORMONE; PROLACTIN; PROSTAGLANDIN; SILDENAFIL; TADALAFIL; TESTOSTERONE; VARDENAFIL; YOHIMBINE;

ACROMEGALY; ANDROGEN BLOOD LEVEL; ANDROGEN DEFICIENCY; BEHAVIOR THERAPY; CLITOROMEGALIA; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EJACULATION; ENDOCRINE DISEASE; FEMALE SEXUAL DYSFUNCTION; HORMONAL REGULATION; HORMONE RELEASE; HUMAN; HYPERPROLACTINEMIA; HYPOGONADISM; HYPOPHYSIS ADENOMA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; IMPOTENCE; LIBIDO DISORDER; MEDICAL LITERATURE; MENTAL STRESS; ORGASM; ORGASM DISORDER; PENILE BLOOD FLOW; PENIS PROSTHESIS; PRIORITY JOURNAL; PSYCHOSOMATIC DISORDER; REVIEW; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SUBCLINICAL HYPOGONADISM; SYMPTOM; TESTOSTERONE BLOOD LEVEL; VAGINA DISEASE; VAGINA SECRETION;

ADRENAL GLAND DISEASES; DIAGNOSIS, DIFFERENTIAL; ENDOCRINE SYSTEM DISEASES; FEMALE; HUMANS; HYPERPROLACTINEMIA; HYPOGONADISM; HYPOTHALAMIC DISEASES; MALE; PITUITARY DISEASES; PSYCHOPHYSIOLOGIC DISORDERS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; STATISTICS; THYROID DISEASES;

EID: 34147194579     PISSN: 00333190     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099840     Document Type: Review

References (64)

1. Morin LP, Dark J: Hormones and biological rhythms; in Becker JB, Breedlove SM, Crews D (eds): Behavioral Endocrinology. Cambridge, MIT Press, 1992, pp 473-504.
2. Oster H, Maronde E, Albrecht U: The circadian clock as a molecular calendar. Chronobiol Int 2002;19:507-516.
3. Malpaux B, Migaud M, Tricoire H, Chemineau P: Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. J Biol Rhythms 2001;16:336-347.
4. Lombardo F, Gandini L, Santulli M, Jannini EA, Dondero F, Lenzi A: Endocrinological diagnosis in sexology. J Endocrinol Invest 2003;26(suppl 3):112-114.
5. Sobrinho LG: Psychopathology in endocrine disorders: why so persistent after the cure? Psychother Psychosom 2004;73:65-67.
6. Sonino N, Navarrini C, Ruini C, Ottolini F, Paoletta A, Fallo F, Boscaro M, Fava GA: Persistent psychological distress in patients treated for endocrine disease. Psychother Psychosom 2004;73:78-83.
7. Fabbri A, Jannini EA, Gnessi L, Moretti C, Ulisse S, Bonifacio V, Frajese G, Isidori A: Evidence for low bioactive LH in male impotence: possible relationship with altered GnRH pulsatility. J Clin Endocrinol Metab 1988;67:867-875.
8. Jannini EA, Screponi E, Carosa E, Pepe M, Lo Giudice F, Trimarchi F, Benvenga S: Lack of sexual activity from erectile dysfunction is associated with a reversible reduction in serum testosterone. Int J Androl 1999;22:385-392.
9. Carosa E, Benvenga S, Trimarchi F, Lenzi A, Pepe M, Simonelli C, Jannini EA: Lack of sexual activity for erectile dysfunction causes a reversible reduction of LH bioavailability. Int J Impotence Res 2002;14:93-99.
10. Carosa E, Martini P, Brandetti F, Di Stasi SM, Lombardo F, Lenzi A, Jannini EA: Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol 2004;61:382-386.
11. Fabbri A, Jannini EA, Gnessi L, Moretti C, Ulisse S, Franzese A, Lazzari R, Fraioli F, Frajese G, Isidori A: Endorphins in male impotence: evidence for naltrexone stimulation of erectile activity in patient therapy. Psychoneuroendocrinology 1989;14:103-111.
12. Veldhuis JD, Rogol AD, Samojlik E, Ertel NH: Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man. J Clin Invest 1984;74:47-55.
13. Lightman SL, Jacobs HS, Maguire AK, McGarrick G, Jeffcoate WL: Constancy of opioid control of luteinizing hormone in different pathophysiological states. J Clin Endocrinol Metab 1981;52:1260-1263.
14. Plourde PV, Dufau ML, Plourde N, Santen RJ: Impotence associated with low biological to immunological ratio of luteinizing hormone in a man with a pituitary stone. J Clin Endocrinol Metab 1985;60:797-802.
15. Mohr BA, Guay AT, O'Donnell AB, McKinlay JB: Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study. Clin Endocrinol 2005;62:64-73.
16. Carani C, Celani MF, Zini D, Baldini A, Della Casa L, Marrama P: Changes in the bioactivity to immunoreactivity ratio of circulating luteinizing hormone in impotent men treated with testosterone undecanoate. Acta Endocrinol 1989;120:284-288.
17. Rhoden EL, Teloken C, Mafessoni R, Vargas Souto CA: Is there a relation between serum levels of total testosterone and the severity of erectile dysfunction? Int J Impot Res 2002;14:167-171.
18. Anonymous: Effects of sexual activity on beard growth in man. Nature 1970;226:869-870.
19. Graham JM, Desjardins C: Classical conditioning: induction of luteinizing hormone and testosterone secretion in anticipation of sexual activity. Science 1980;210:1039-1041.
20. Fox CA, Ismail AA, Love DN, Kirkham KE, Loraine JA: Studies on the relationship between plasma testosterone levels and human sexual activity. J Endocrinol 1972;52:51-58.
21. Hirschenhauser K, Frigerio D, Grammer K, Magnusson MS: Monthly patterns of testosterone and behavior in prospective fathers. Horm Behav 2002;42:172-181.
22. Rubin H, Henson D, Falvo R, High RW: The relationship between men's endogenous levels of testosterone and their penile response to erotic stimuli. Behav Res Ther 1979;17:305-312.
23. Lange JD, Brown WA, Wincze JP, Zwick W: Serum testosterone concentration and penile tumescence changes in men. Horm Behav 1980;14:267-270.
24. Stoleru SG, Ennaji A, Cournot A, Spira A: LH pulsatile secretion and testosterone levels are influenced by sexual arousal in human males. Psychoneuroendocrinology 1993;18:205-218.
25. Becker AJ, Uckert S, Stief CG, Truss MC, Machtens S, Sheller F, Knapp WH, Hartmann U, Jonas U: Cavernous and systemic testosterone levels in different phases of human penile erection. Urology 2000;56:125-129.
26. Becker AJ, Uckert S, Stief CG, Sheller F, Knapp WH, Hartmann U, Jonas U: Cavernous and systemic testosterone plasma levels during different conditions in healthy males and patients with erectile dysfunction. Urology 2001;58:435-440.
27. Ansong KS, Punwaney RB: An assessment of the clinical relevance of serum testosterone level determination in the evaluation of men with low sexual drive. J Urol 1999;162:719-721.
28. Ahn HS, Park CM, Lee SW: The clinical relevance of sex hormone levels and sexual activity in the ageing male. Br J Urol Intern 2002;9:526-530.
29. Tsitouras PD, Martin CE, Barman SM: Relationship of serum testosterone to sexual activity in healthy elderly me. J Gerontol 1982;37:288-293.
30. English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS: Men with coronary disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J 2000;21:890-894.
31. Fogari R, Zoppi A, Preti P, Rinaldi A, Marasi G, Vanesia A, Mugellini A: Sexual activity and plasma testosterone levels in hypertensive males. Am J Hypertens 2002;15:217-221.
32. Aversa A, Isidori AM, De Martino MU, Caprio M, Fabbrini E, Rocchietti-March M, Frajese G, Fabbri A: Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilatation in men with erectile dysfunction. Clin Endocrinol 2000;53:517-522.
33. Caruso A, Intelisano G, Farina M, Di Mari L, Agnello C, Giammusso B: Efficacy and safety of daily intake of apomorphine SL in men affected by erectile dysfunction and mild hyperprolactinemia: a prospective, open-label, pilot study. Urology 2003;62:922-927.
34. Jannini EA, Lenzi A, Wagner G: New perspectives in the pharmacotherapy of erectile dysfunction. IDrugs 2003;6:1165-1172.
35. Morelli A, Filippi S, Mancina R, Luconi M, Vignozzi L, Marini M, Orlando C, Vannelli GB, Aversa A, Natali A, Forti G, Giorni M, Jannini EA, Ledda F, Maggi M: Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology 2004;145:2253-2263.
36. Foresta C, Caretta N, Rossato M, Garolla A, Ferlin A: Role of androgens in erectile function. J Urol 2004;171:2358-2362.
37. Davidson JM, Camargo C, Smith ER: Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab 1979;48:955-958.
38. Nankin HR, Lin T, Osterman J: Chronic testosterone cypionate therapy in men with secondary impotence. Fertil Steril 1986;46:300-306.
39. Morales A, Johnston B, Heaton JWP, Clark A: Oral androgen in the treatment of hypogonadal impotent men. J Urol 1994;152:1115-1118.
40. Morales A, Johnston B, Heaton JPW, Lundie M: Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes. J Urol 1998;157:849-854.
41. Guay AT, Bansal S, Heatley GJ: Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate. J Clin Endocrinol Metab 1995;80:3546-3552.
42. Anderson BA, Bancroft J, Wu FCW: The effects of exogenous testosterone on sexuality and mood in normal men. J Clin Endocrinol Metab 1992;75:1503-1507.
43. Greenstein A, Playmate SR, Katz PG: Visually stimulated erections in castrated men. J Urol 1995;153:650-652.
44. Finkelstein JW, Susman EJ, Chinchilli VM, Kunselman SJ, D'Arcangelo MR, Schwab J, Demers LM, Liben LS, Lookingbill G, Kulin HE: Estrogen or testosterone increases selfreported aggressive behaviors in hypogonadal adolescents. J Clin Endocrinol Metab 1997;82:2423-2438.
45. Swerdloff RS Wang C: Influence of pituitary disease on sexual development and functioning. Psychother Psychosom 1998;67:173-180.
46. Fava GA, Fava M, Kellner R, Serafini E, Mastrogiacomo J: Depression, hostility and anxiety in hyperprolactinemic amenorrea. Psychoter Psychosom 1981;36:122-128.
47. Buvat J: Hyperprolactinemia and sexual function in men: a short review. Int J Impot Res 2003;15:373-377.
48. De Rosa M, Zarrilli S, Vitale G, Di Somma C, Orio F, Tauchmanova L, Lombardi G, Colao A: Six months of treatment wit cabergoline restores sexual potency in hyperprolactinemic males: an open longitudinal study monitoring nocturnal penile tumescence. J Clin Endocrinol Metab 2004;89:621-625.
49. Sonino N, Navarrini C, Ruini C, Fallo F, Boscaro M, Fava GA: Life events in the pathogenesis of hyperprolactinemia. Eur J Endocrinol 2004;151:61-65.
50. Barman AL: Acromegaly, diagnosis and therapy. Endocrinol Metab Clin 1989;18:277-310.
51. Rowles SV, Prieto L, Badia X, Shalet SM, Webb SM, Trainer PJ: Quality of life (QOL) in patients with acromegaly is severely impaired: use of a novel measure of QOL: acromegaly quality of life questionnaire. J Clin Endocrinol Metab 2005;90:3337-3341.
52. Becker AJ, Uckert S, Stief CG, Truss MC, Machtens S, Sheller F, Knapp WH, Hartmenn U, Jonas U: Possible role of human growth hormone in penile erection. J Urol 2000;164:2138-2142.
53. Jannini EA, Ulisse S, D'Armiento M: Thyroid hormone and male gonadal function. Endocrine Rev 1995;16:443-459.
54. Corona G, Petrone L, Mannucci E, Jannini EA, Mansani R, Magini A, Giommi R, Forti G, Maggi M: Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur Urol 2004;46:615-622.
55. Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, Jannini EA: Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab 2005;90:6472-6479.
56. Sonino N, Fava GA: Psychiatric disorders associated with Cushing's syndrome. Epidemiology, pathophysiology and treatment. CNS Drugs 2001;15:361-373.
57. Uckert S, Fuhlenriede MH, Becker AJ, Stief CG, Scheller F, Knapp WH, Jonas U: Is there an inhibitory role of cortisol in the mechanism of male sexual arousal and penile erection? Urol Res 2003;31:402-406.
58. Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, Herbert J, Chatterjee VK: Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650-4656.
59. Jannini EA: Dehydroepiandrosterone treatment in the aging male - What should the urologist know - commentary. Eur Urol 2005;48:733.
60. Melman A, Gingell JC: The epidemiology and pathophysiology of erectile dysfunction. J Urol 1999;161:5-11.
61. Rosen RC: Assessment of female sexual dysfunction: review of validated methods. Fertil Steril 2002;77:S89-S93.
62. Traish AM, Kim N, Min K, Munarriz R, Goldstein I: Role of androgens in female genital sexual arousal: receptor expression, structure and function. Fertil Steril 2002;77:S11-S18.
63. Guay AT, Spark R: Pathophysiology of sex steroids in women; in Goldstein I, Meston CM, Davis SR, Traish AM (eds): Women's Sexual Function and Dysfunction. London, Taylor & Francis, 2005, pp 218-227.
64. Sternbach H: Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry 1998;155:1310-1318.