Modifications of DCDHF single molecule fluorophores to impart water solubility

Tetrahedron Letters

Volumn 48, Issue 19, 2007, Pages 3471-3474

  Wang, Hui ^a   Lu, Zhikuan ^a   Lord, Samuel J ^b   Moerner, W E ^b   Twieg, Robert J ^a  

^a KENT STATE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICYANOMETHYLENEDIHYDROFURAN; FURAN DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; HYDROPHILICITY; SOLUBILITY; SYNTHESIS; SYSTEMS BIOLOGY;

EID: 34147181486     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.03.026     Document Type: Article

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14. 2O sample. The results reported are averages of duplicate runs. (Benbow, J. W.; Bernberg, E. L.; Korda, A.; Mead J. R. Antimicrob. Agents Chemother., 1998, 42, 339-343).
15. General methods to obtain fluorophores 12, 14-17, 25: the starting disubstituted amine was mixed with precursor 10 in dry pyridine. The reaction mixture was then stirred at room temperature or heated to 40 °C overnight depending on the substrate. Pyridine was then distilled out under vacuum and the residue was purified via flash chromatography.
16. 2NEt. The reaction mixture was then stirred at 40 °C overnight. Hydrochloric acid (10%) was added and the suspension was filtered to give the product as a yellow solid.