No difference in leprosy treatment outcomes comparing 12- and 24-dose multidrug regimens: A preliminary study

Cadernos de Saude Publica

Volumn 23, Issue 4, 2007, Pages 815-822

  Sales, Anna Maria ^a   Sabroza, Paulo Chagastelles ^a   Nery, José Augusto Da Costa ^a   Dupprè, Nádia Cristina ^a   Sarno, Euzenir Nunes ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Comparative study; Drug therapy; Leprosy

Indexed keywords

LEPROSTATIC AGENT;

ADULT; ARTICLE; CLINICAL PROTOCOL; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG COMBINATION; FEMALE; HUMAN; LEPROMATOUS LEPROSY; MALE; MICROBIOLOGY; STATISTICAL MODEL; TIME; TREATMENT OUTCOME;

ADULT; CLINICAL PROTOCOLS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LEPROSTATIC AGENTS; LEPROSY, LEPROMATOUS; LINEAR MODELS; MALE; TIME FACTORS; TREATMENT OUTCOME;

EID: 34147172883     PISSN: 0102311X     EISSN: 16784464     Source Type: Journal    
DOI: 10.1590/S0102-311X2007000400009     Document Type: Article

References (21)

1. World Health Organization. Chemotherapy of leprosy for control programmes. Geneva: World Health Organization; 1982. (WHO Technical Report Series, 675).
2. World Health Organization. Progress towards the elimination of leprosy as a public health problem. Wkly Epidemiol Rec 1993; 68:181-8.
3. World Health Organization. Shortening duration of treatment of multibacillary leprosy. Wkly Epidemiol Rec 1997; 72:173-80.
4. Beck-Bleumink M. Relapses among leprosy patients treated with multidrug therapy, experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational procedures and criteria for diagnosing relapses. Int J Lepr 1992; 60:421-35.
5. Oliveira MLW. Cura da hanseníase - magnitude das recidivas no Brasil - estudo de coorte de diferentes esquemas terapêuticos e fatores de risco [Tese de Doutorado]. Rio de Janeiro: Universidade Federal do Rio de Janeiro; 1996.
6. Ponnighaus JM, Boerrigter G. Are 18 doses of WHO/MDT sufficient for multibacillary leprosy? Results of a trial in Malawi. Int J Lepr 1995; 63:1-7.
7. Andrade VLG, Boechat AM, Viana FR, Avelleira JCR. Estudo do índice baciloscópico em pacientes de hanseníase multibacilares durante tratamento com esquema MDT/OMS e no período de dois anos após a interrupção da terapêutica. An Bras Dermatol 1993; 68 Suppl 4:191-3.
8. Pattyn SR, Bourland J, Grillone S, Groenen G, Ghys P. Combined regimens of one year duration in the treatment of multibacillary leprosy -I. Combined regimens with rifampicin administered during one year. Lepr Rev 1989; 60:109-17.
9. Pattyn SR. Efficacy of different regimens in multibacillary leprosy. Lepr Rev 1986; 57 Suppl 3:265-71.
10. Ji B. Why multidrug therapy for multibacillary leprosy can be shortened to 12 months [Editorial]. Lepr Rev 1998; 69:106-9.
11. World Health Organization. WHO Expert Committee on Leprosy. Geneva: World Health Organization; 1998. (WHO Technical Report Series, 874).
12. International Leprosy Association. Summary of the Report of the ILA Technical Forum. Int J Lepr 2002; 70(1 Suppl):S3-S5.
13. Ridley DS, Jopling WH. Classification of leprosy according to immunity - a five-group system. Int J Lepr 1966; 54:255-73.
14. Ministério da Saúde. Guia de controle da hanseníase. Brasília: Divisão Nacional de Dermatologia Sanitária, Ministério da Saúde; 1983.
15. Gallo MEN, Alvim MFS, Nery JAC, Albuquerque ECAA. Estudo comparativo com dois esquemas poliquimioterápicos (duração fixa) em hanseníase multibacilar-seguimento de 50.32 ± 19.62 e 39.70 ± 19.47 meses. Hansenol Int 1997; 22 Suppl 1:5-14.
16. Irudayaraj J, Aschhof FM. Assessment criteria and multidrug therapy. Int J Lepr 1989; 57:426-89.
17. De Rijik AJ, Nilsson T, Chonde M. Quality control of skin smear services in leprosy programmes: preliminary experience with inter-observer comparison in routine services. Lepr Rev 1995; 56:177-91.
18. Vijayakumaran P, Manimochi N, Jesudasan K. Incidence of late lepra reaction among multibacillary leprosy patients after MDT. Int J Lepr 1995; 63 Suppl 1:18-22.
19. Girdhar BK, Girdhar A, Kumar A. Relapses in multibacillary leprosy patients: effect of length of therapy. Lepr Rev 2000; 71:144-53.
20. Nery JA, Vieira LMM, Mattos HJ, Gallo MEM, Sarno EN. Reactional states in multibacillary disease patients during multidrugtherapy. Rev Inst Med Trop São Paulo 1998; 40:363-70.
21. Kaur I, Dogra S, Kumar B, Radotra BD. Combined 12-Month WHO/MDT multibacillary regimen and Mycobacterium w. Vaccine in multibacillary leprosy - a follow-up of 136 patients. Int J Lepr 2002; 70:175-81.