Surgical treatments for vulvar and vaginal dysplasia: A randomized controlled trial

Obstetrics and Gynecology

Volumn 109, Issue 4, 2007, Pages 942-947

  Von Gruenigen, Vivian E ^a   Gibbons, Heidi E ^b   Gibbins, Karen ^b   Jenison, Eric L ^b   Hopkins, Michael P ^b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ASPIRATION; CARBON DIOXIDE LASER; CLINICAL TRIAL; COLPOSCOPY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; DYSPLASIA; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; OBSTETRIC OPERATION; PAIN ASSESSMENT; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; STATISTICAL ANALYSIS; STUDENT T TEST; VAGINAL INTRAEPITHELIAL NEOPLASIA; VISUAL ANALOG SCALE; VULVA DISEASE; WOUND HEALING;

CARCINOMA IN SITU; CICATRIX; FEMALE; FOLLOW-UP STUDIES; HUMANS; LASER SURGERY; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TREATMENT OUTCOME; ULTRASONIC THERAPY; VAGINAL DISEASES; VULVAR DISEASES;

EID: 34147162824     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000258783.49564.5c     Document Type: Article

References (30)

1. Bonvicini F, Venturoli S, Ambretti S, Paterini P, Santini D, Ceccarelli C, et al. Presence and type of oncogenic human papillomavirus in classic and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma. J Med Virol 2005;77:102-6.
2. Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol 2005;106:1319-26.
3. Dodge JA, Eltabbakh GH, Mount SL, Walker RP, Morgan A. Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia. Gynecol Oncol 2001;83:363-9.
4. Thuis YN, Campion M, Fox H, Hacker NF. Contemporary experience with the management of vulvar intraepithelial neoplasia. Int J Gynecol Cancer 2000;10:223-7.
5. Reitano M. Counseling patients with genital warts. Am J Med 1997;102:38-43.
6. Indermaur MD, Martino MA, Fiorica JV, Roberts WS, Hoffman MS. Upper vaginectomy for the treatment of vaginal intraepithelial neoplasia. Am J Obstet Gynecol 2005;193:577-80.
7. Jones RW, Rowan DM. Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma. Obstet Gynecol 1994;84:741-5.
8. Bernstein SG, Kovacs BR, Townsend DE, Morrow CP. Vulvar carcinoma in situ. Obstet Gynecol 1983;61:304-7.
9. Haidopoulos D, Diakomanolis E, Rodolakis A, Voulgaris Z, Vlachos G, Intsaklis A. Can local application of imiquimod cream be an alternative mode of therapy for patients with high-grade intraepithelial lesions of the vagina? Int J Gynecol Cancer 2005;15:898-902.
10. Todd RW, Etherington IJ, Luesley DM. The effects of 5% imiquimod cream on high-grade vulval intraepithelial neoplasia. Gynecol Oncol 2002;85:67-70.
11. Le T, Hicks W, Menard C, Hopkins L, Fung MF. Preliminary results of 5% immiquimod cream in the primary treatment of vulva intraepithelial neoplasia grade 2/3. Am J Obstet Gynecol 2006;194:377-380.
12. Daly JW, Ellis GF. Treatment of vaginal dysplasia and carcinoma in situ with topical 5-fluorouracil. Obstet Gynecol 1098;55:350-2.
13. U.S. Food and Drug Administration. Aldara (imiquimod) cream, 5%. Available at: http://www.fda.gov/medwatch/SAFETY/2004/mar_PI/Aldara_PI.pdf. Retrieved September 25, 2006.
14. Hoffman MS, Roberts WS, LaPolla JP, Fiorica JV, Cavanagh D. Laser vaporization of grade 3 vaginal intraepithelial neoplasia. Am J Obstet Gynecol 1991;165:1342-4.
15. Sideri M, Spinaci L, Spolti N, Schettino F. Evaluation of CO(2) laser excision or vaporization for the treatment of vulvar intraepithelial neoplasia. Gynecol Oncol 1999;75:277-81.
16. Hoffman MS, Pinelli DM, Finan M, Roberts WS, Fiorica JV, Cavanagh D. Laser vaporization for vulvar intraepithelial neoplasia III. J Reprod Med 1992;37:135-7.
17. Yalcin OT, Rutherford TJ, Chambers SK, Chambers JT, Schwartz PE. Vaginal intraepithelial neoplasia: treatment by carbon dioxide laser and risk factors for failure. Eur J Obstet Gynecol Reprod Biol 2003;106:64-8.
18. Campagnutta E, Parin A, De Piero G, Giorda G, Gallo A, Scarabelli C. Treatment of vaginal intraepithelial neoplasia (VAIN) with the carbon dioxide laser. Clin Exp Obstet Gynecol 1999;26:127-30.
19. Julian TM, O'Connell BJ, Gosewehr JA. Indications, techniques, and advantages of partial laser vaginectomy. Obstet Gynecol 1992;80:140-3.
20. Wright VC, Davies E. Laser surgery for vulvar intraepithelial neoplasia: principles and results. Am J Obstet Gynecol 1987;156:374-8.
21. Hillemanns P, Wang X, Staehle S, Michels W, Dannecker C. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol 2006;100:271-5.
22. Wu AY, Sherman ME, Rosenshein NB, Erozan YS. Pathologic evaluation of gynecologic specimens obtained with the cavitron ultrasonic surgical aspirator (CUSA). Gynecol Oncol 1992;44:28-32.
23. Rader JS, Leake JF, Dillon MB, Rosenshein NB. Ultrasonic surgical aspiration in the treatment of vulvar disease. Obstet Gynecol 1991;77:573-6.
24. Miller BE. Vulvar intraepithelial neoplasia treated with cavitational ultrasonic surgical aspiration. Gynecol Oncol 2002;85:114-8.
25. Robinson JB, Sun CC, Bodurka-Bevers D, Im DD, Rosenshein NB. Cavitational ultrasonic surgical aspiration for the treatment of vaginal intraepithelial neoplasia. Gynecol Oncol 2000;78:235-41.
26. Rader JS, Rest EB, Farmer ER, Rosenshein NB. A comparison of wound healing after epithelial resection by ultrasonic surgical aspiration and ablation by the carbon dioxide laser. Gynecol Oncol 1992;46:351-6.
27. Jensen MP, Chen C, Brugger AM. Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain. J Pain 2003;4:407-14.
28. Woodman CB, Mould JJ, Jordan JA. Radiotherapy in the management of vaginal intraepithelial neoplasia after hysterectomy. Br J Obstet Gynaecol 1988;95:976-9.
29. Krebs HB. Treatment of vaginal intraepithelial neoplasia with laser and topical 5-fluorouracil. Obstet Gynecol 1989;73:657-60.
30. Functional Assessment of Chronic Illness. Available at: http://www.facit.org. Retrieved September 26, 2006.