Single versus repeat courses of antenatal steroids to improve neonatal outcomes: Risks and benefits

Obstetrical and Gynecological Survey

Volumn 62, Issue 4, 2007, Pages 261-271

  Bonanno, Clarissa ^a,b   Fuchs, Karin ^a,b   Wapner, Ronald J ^a,b,c  

^a Department of Obstetrics and Gynecology ^*  (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; DEXAMETHASONE; STEROID;

BIRTH WEIGHT; CHEMICAL ANALYSIS; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FETUS GROWTH; FETUS MATURITY; HEAD CIRCUMFERENCE; HOSPITAL DISCHARGE; HUMAN; LUNG DEVELOPMENT; LUNG FUNCTION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHYSIOLOGY; PREMATURITY; RESPIRATORY DISTRESS SYNDROME; REVIEW; RISK BENEFIT ANALYSIS; SINGLE DRUG DOSE; TREATMENT INDICATION; WEIGHT REDUCTION;

ADRENAL CORTEX HORMONES; FEMALE; FETAL DEVELOPMENT; FETAL ORGAN MATURITY; HUMANS; INFANT, NEWBORN; LUNG; PREGNANCY; PREGNANCY OUTCOME; PREMATURE BIRTH; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 34147162141     PISSN: 00297828     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ogx.0000259226.62431.78     Document Type: Review

References (65)

1. Hamilton BE, Ventura ST, Martin JA, et al. Preliminary Births for 2004. Health E-Stats. National Center for Health Statistics, 2004.
2. Liggins GC. Premature delivery of fetal lambs infused with glucocorticoids. J Endocrinol 1969;45:515-523.
3. Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972;50:515-525.
4. Liggins GC, Howie RN. Prevention of respiratory distress syndrome in premature infants by antepartum glucocorticoid treatment. In: Villee CA, Villee DB, Zuckerman J, eds. Respiratory Distress Syndrome. London: Academic Press, 1973:369-380.
5. Howie RN, Liggins GC. Clinical trials of antepartum betamethasone for prevention of respiratory distress in preterm infants. In: Preterm Labor: Proceedings of the Fifth Study Group of the Royal College of Obstetricians and Gynecologists. London: Royal College of Obstetricians and Gynecologists; 1977:281-289.
6. NIH Consensus Development Panel. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995;273:413-418.
7. Crowley P, Chalmers I, Keirse MJNC. The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol 1990;97:11-25.
8. Leviton LC, Golderberg RL, Baker CS, et al. Methods to encourage the use of antenatal corticosteroid therapy for fetal maturation: a randomized controlled trial. JAMA 1999;281:46-52.
9. Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev 1996;(1).
10. McLaughlin KL, Crowther CA, Walker N, et al. Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review. Aust N Z J Obstet Gynecol 2003;43:101-106.
11. Planer BC, Ballard RA, Ballard PL, et al. Antenatal corticosteroid (ANCS) use in preterm labor in the USA. Pediatr Res 1996;39:110A.
12. NIH Consensus Development Panel. Antenatal corticosteroids revisited: repeat courses. Obstet Gynecol 2000;98:144-150.
13. Bolt RJ, Weissenbruch MM, Lafeber HN, et al. Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol 2001;32:76-91.
14. Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Am J Obstet Gynecol 1995;173:254-262.
15. Frank L, Lewis PL, Sosenko IRS. Dexamethasone stimulation of fetal rat lung antioxidant enzyme activity in parallel with surfactant stimulation. Pediatrics 1985;75:569-74.
16. O'Brodovich H, Canessa C, Ueda J, et al. Expression of epithelial Na+ channel I the developing rat lung. Am J Physiol 1993;34:C491-C496.
17. Celsi G, Wang ZM, Akusjarvi G, et al. Sensitive periods for glucocorticoids regulation of Na,K-ATPase mRNA in the developing lung and kidney. Pediatr Res 1993;33:5-9.
18. Ikegami M, Jobe AH, Newnham J, et al. Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med 1997;156:178-184.
19. Jobe AH, Soll RF. Choice and dose of corticosteroid for antenatal treatments. Am J Obstet Gynecol 2004;190:878-881.
20. Crowley P. Prophylactic steroids for preterm birth. Cochrane Database Syst Rev 2000;2.
21. Lee BH, Stoll BJ, McDonald SA, et al. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics 2006;117:1503-1510.
22. Baud O, Foix-L'Helias L, Kaminski, et al. Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants. N Engl J Med 1999;341:1190-1196.
23. Aghajafari F, Murphy K, Matthews S, et al. Repeated doses of antenatal corticosteroids in animals: a systematic review. Am J Obstet Gynecol 2002;186:843-849.
24. Ballard PL, Ning Y, Polk D, et al. Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol 1997;273:L1048-L1057.
25. Walther FJ, Jobe A, Ikegami M. Repetitive prenatal glucocorticoid therapy reduces oxidative stress in the lungs of preterm lambs. J Appl Physiol 1998;85:273-278.
26. Engle MJ, Kemnitz JW, Rao TJ, et al. Effects of maternal dexamethasone therapy on fetal lung development in the rhesus monkey. Am J Perinatol 1996;13:399-407.
27. Pratt L, Magness RR, Phernetton T, et al. Multiple use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome. Am J Obstet Gynecol 1999;180:995-1005.
28. Stewart JD, Sienko AE, Gonzalez CL, et al. Placebo-controlled comparison between a single dose and a multidose of betamethasone in accelerating lung maturation of mice offspring. Am J Obstet Gynecol 1998;179:1241-1247.
29. Dunlop SA, Archer MA, Quinlivan JA, et al. Multiple prenatal corticosteroids delay myelination in the ovine central nervous system. J Matern Fetal Med 1997;6:309-313.
30. Quinlivan JA, Beazley LD, Evans SF, et al. Retinal maturation is delayed by repeated, but not single maternal injections of betamethasone in sheep. Eye 2000;14:93-98.
31. Huang WL, Beazley LD, Quinlivan JA, et al. Effects of corticosteroids on brain growth in fetal sheep. Obstet Gynecol 1999;94:213-218.
32. Uno H, Lohmiller L, Tieme C, et al. Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Brain Res Dev Brain Res 1990;53:157-167.
33. Rayburn WF, Christensen HD, Gonzales CL, et al. Effects of in utero exposure to betamathasone on motivation/anxiety testing in mice offspring. Neurotoxicol Teratol 1998;20:475-481.
34. Quinlivan JA, Archer MA, Dunlop SA, et al. Fetal growth retardation, particularly within lymphoid organs, following repeated maternal injections of betamethasone in sheep. J Obstet Gynecol Res 1998;24:173-182.
35. Moss TJ, Doherty DA, Nitsos I, et al. Effects into adulthood of single or repeated antenatal corticosteroids in sheep. Am J Obstet Gynecol 2005;192:146-52.
36. Newnham JP, Evans SF, Godfrey ME, et al. Maternal, but not fetal, administration of corticosteroids restricts fetal growth. J Matern Fetal Med 1999;8:81-87.
37. Newnham JP, Moss TJ, Padbury JF, et al. The interactive effects of endotoxin with prenatal glucocorticoids on shortterm lung function in sheep. Am J Obstet Gynecol 2001;185:190-197.
38. Abbasi S, Hirsch D, Davis J, et al. Effect of single vs. multiple courses of antenatal steroids on maternal and neonatal outcome. Am J Obstet Gynecol 2000;182:1243-1249.
39. Elimian A, Verma U, Visintainer P, et al. Effectiveness of multiple-dose antenatal steroids. Obstet Gynecol 1999;95:34-36.
40. Allen VM, Allen AC, Usher RH, et al. The effect of repeated courses of antenatal corticosteroids on the prevention of complications of prematurity. Am J Obstet Gynecol 1997;176:A134.
41. Peaceman AM, Bajaj K, Kumar P, et al. The interval between a single course of antenatal steroids and delivery and its association with neonatal outcomes. Am J Obstet Gynecol 2005;193:1165-1169.
42. Banks BA, Cnaan A, Morgan MA, et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates. North American Thyrotropin-Releasing Hormone Study Group. Am J Obstet Gynecol 1999;181:709-717.
43. Bradley BS, Kumar SP, Mehta PN, et al. Neonatal cushingoid syndrome resulting from serial courses of antenatal betamethasone. Obstet Gynecol 1994;83:869-872.
44. Terrone DA, Rinehart BK, Rhodes PG, et al. Multiple courses of betamethasone to enhance fetal lung maturation do not suppress neonatal adrenal response. Am J Obstet Gynecol 1999;180:1349-1353.
45. French H, Hagan R, Evans S, et al. Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol 1999;180:114-121.
46. Bloom SL, Sheffield JS, Mcintire DD, et al. Antenatal dexamethasone and decreased birth weight. Obstet Gynecol 2001;97:485-490.
47. Thorp JA, Jones PG, Knox E, et al. Does antenatal corticosteroid therapy affect birth weight and head circumference? Obstet Gynecol 2002;99:101-108.
48. Pratt L, Waschbusch L, Ladd W, et al. Multiple vs. single betamethasone therapy: neonatal and maternal effects. J Reprod Med 1999;44:257-264.
49. Shelton SD, Boggess KA, Murtha AP, et al. Repeated fetal betamethasone treatment and birth weight and head circumference. Obstet Gynecol 2001;97:301-304.
50. Rotmensch S, Vishne TH, Reece EA, et al. Long-term outcomes of infants exposed to repeated courses of betamethasone in utero. Am J Obstet Gynecol 1999;180:324A.
51. French NP, Hagan R, Evans SF, et al. Repeat antenatal corticosteroids: effects on cerebral palsy and childhood behavior. Am J Obstet Gynecol 2004;190:588-595.
52. Spinillo A, Viazzo F, Colleoni R, et al. Two-year infant neurodevelopmental outcome after single or multiple antenatal courses of corticosteroids to prevent complications of prematurity. Am J Obstet Gynecol 2004;191:217-224.
53. Thorp JA, Etzenhouser J, O'Connor M, et al. Effects of phenobarbital and multiple-dose antenatal/postnatal steroid on developmental outcome at age 7 years. Am J Obstet Gynecol 2002;185:S87.
54. Guinn DA, Atkinson MA, Sullivan L, et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA 2001;286:1581-1587.
55. Wapner RJ, Sorokin Y, Thom EA, et al. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 2006;195:633-642.
56. Wapner RJ. Maternal and fetal adrenal function following single and repeat corticosteroids. Am J Obstet Gynecol 2005;193:S5.
57. Crowther CA, Haslam RR, Hiller JE, et al. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomized controlled trial. Lancet 2006;367:1913-1919.
58. Boggess KA, Bailit JL, Singer ME, et al. Projected benefits of universal or scheduled antepartum corticosteroids to prevent neonatal morbidity: a decision analysis. Am J Obstet Gynecol 2005;193:1415-1423.
59. Caughey AB, Parer JT. Recommendations for repeat courses of antenatal corticosteroids: a decision analysis. Am J Obstet Gynecol 2002;186:1221-1229.
60. Halliday HL, Ehrenkranz RA, Doyle LW. Early postnatal (<96 hours) corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2006;(3).
61. Halliday HL, Ehrenkranz RA, Doyle LW. Moderately early (7-14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2006;(3).
62. Halliday HL, Ehrenkranz RA, Doyle LW. Delayed (>3 weeks) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2006;(3).
63. Committee on Fetus and Newborn. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 2002;109:330-338.
64. Yeh TF, Lin YJ, Lin HC, et al. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N Engl J Med 2004;350:1304-1313.
65. Vermillion ST, Bland ML, Soper DE. Effectiveness of a rescue dose of antenatal betamethasone after an initial single dose. Am J Obstet Gynecol 2001;185:1086-1089.