Papain-catalysed synthesis of Z-l-aminoacyl-antipyrine amides from Z-protected amino acid esters and 4-aminoantipyrine

Tetrahedron Letters

Volumn 48, Issue 19, 2007, Pages 3371-3374

  Lang, Alexander ^a   Hatscher, Catharina ^a   Kuhl, Peter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

4 Aminoantipyrine; Enzymatic synthesis; Papain

Indexed keywords

4 AMINOPHENAZONE; AMIDE; AMINO ACID; ESTER DERIVATIVE; HETEROCYCLIC COMPOUND; KETONE DERIVATIVE; PAPAIN; PROTEINASE;

ARTICLE; CATALYSIS; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; POLARIMETRY; SUSPENSION CELL CULTURE;

EID: 34147157111     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.03.067     Document Type: Article

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12. 3. The solution was washed twice with saturated sodium bicarbonate solution, and the two phases were separated. AAP was extracted with 1 M HCl from the organic phase as long as the reaction of the aqueous phase with Ehrlich reagent turned out positive. Then the organic layer was dried with sodium sulfate, filtered and evaporated. The obtained product was desiccated overnight at 40 °C.
13. 5), 155.79 (CO), 161.61 (CO), 172.19 (CO).
14. 5), 156.52 (CO), 161.70 (CO), 168.65 (CO).
15. 5), 156.40 (CO), 161.69 (CO), 171.15 (CO).