Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients

Pediatric Transplantation

Volumn 11, Issue 3, 2007, Pages 312-318

  Spivey, John F ^a   Singleton, Dana ^a   Sweet, Stuart ^a   Storch, Gregory A ^a   Hayashi, Robert J ^a   Huddleston, Charles B ^a   Danziger Isakov, Lara A ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cytomegalovirus; Ganciclovir; Lung transplantation; Pediatrics; Viremia

Indexed keywords

AZATHIOPRINE; CEFTAZIDIME; CYCLOSPORIN; DACLIZUMAB; GANCICLOVIR; GENE PRODUCT; GENTAMICIN; PREDNISONE; PROTEIN UL 97; TOBRAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ADOLESCENT; ANOREXIA; ANTIBIOTIC RESISTANCE; ARTICLE; CADAVER DONOR; CATHETER INFECTION; CATHETER REMOVAL; CHEMOPROPHYLAXIS; CHILD; CLINICAL PROTOCOL; CLINICAL TRIAL; COMORBIDITY; CONFUSION; CONGENITAL HEART DISEASE; CYSTIC FIBROSIS; CYTOMEGALOVIRUS INFECTION; DIARRHEA; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG SAFETY; FEASIBILITY STUDY; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GENE MUTATION; GRAM NEGATIVE INFECTION; GROUPS BY AGE; HEART LUNG TRANSPLANTATION; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOSUPPRESSIVE TREATMENT; INDWELLING CATHETER; INFECTION PREVENTION; INJECTION SITE ERYTHEMA; INJECTION SITE SWELLING; KIDNEY DYSFUNCTION; LONG TERM CARE; LUNG BIOPSY; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MALE; NAUSEA; NEPHROTOXICITY; NEUROLOGIC DISEASE; NEUTROPENIA; OPEN STUDY; PEDIATRIC SURGERY; PILOT STUDY; PNEUMONIA; POLYMERASE CHAIN REACTION; POSTOPERATIVE CARE; PSEUDOMONAS AERUGINOSA; PULMONARY HYPERTENSION; SERODIAGNOSIS; THROMBOCYTOPENIA; TREATMENT DURATION; VIREMIA; VIRUS CULTURE; VOMITING; WALKING DIFFICULTY;

ADOLESCENT; ANTIVIRAL AGENTS; CHILD; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GANCICLOVIR; HUMANS; INFUSIONS, INTRAVENOUS; LUNG TRANSPLANTATION; MALE; PILOT PROJECTS; TIME FACTORS; TREATMENT OUTCOME; VIREMIA;

EID: 34147155798     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2006.00626.x     Document Type: Article

References (16)

1. ETTINGER NA, BAILEY TC, TRULOCK EP, et al. Cytomegalovirus infection and pneumonitits. Impact after isolated lung transplantation. Washington University Lung Transplant Group. Am Rev Respir Dis 1993: 147: 1017-1023.
2. PATEL R, PAYA CV. Infections in solid-organ transplant recipients. Clin Microbiol Rev 1997: 10: 86-124.
3. DUNCAN AJ, DUMMER JS, PARADIS IL, et al. Cytomegalovirus infection and survival in lung transplant recipients. J Heart Lung Transpl 1991: 10: 638-644.
4. SMYTH RL, SCOTT JP, HIGENBOTTAM TW, et al. Experience of cytomegalovirus infection in heart-lung transplant recipients. Transpl Proc 1990: 22: 1820-1821.
5. METRAS D, VIARD L, KREITMANN B, et al. Lung infection in pediatric lung transplant: Experience in 49 cases. Eur J Cardiothorac Surg 1999: 15: 490-495.
6. DANZIGER-ISAKOV LA, DELAMORENA M, HAYASHI RJ, et al. Cytomegalovirus viremia associated with death or retransplantation in pediatric lung-transplant recipients. Transplantation 2003: 75: 1538-1543.
7. SCHWARTZ GJ, HAYCOCK GB, EDELMANN CM Jr, et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976: 58: 259-263.
8. SCHWARTZ GJ, FELD LG, LANGFORD DJ. A simple estimate of glomerular filtration rate in full-term infants during the first year of life. J Pediatr 1984: 104: 849-854.
9. SANCHEZ JL, STORCH GA. Multiplex, quantitative, real-time PCR assay for cytomegalovirus and human DNA. J Clin Microbiol 2002: 40: 2381-2386.
10. COOPER JD, BILLINGHAM M, EGAN T, et al. A working formulation for the standardization of the nomenclature and for clinical staging of chronic dysfunction in lung allografts. J Heart Lung Transplant 1993: 12: 713-716.
11. YOUSEM SA, BERRY GJ, CAGLE PT, et al. Revision of the 1990 working formulation of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transpl 1996: 15: 1-15.
12. DANZIGER-ISAKOV LA, FARO A, SWEET S, et al. Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation: Survey of eight pediatric lung transplant programs. Pediatr Transplant 2003: 7: 469-473.
13. DANZIGER-ISAKOV LA, SWEET S, DELAMORENA M, et al. Epidemiology of bloodstream infections in the first year after pediatric lung transplant. Pediatr Infect Dis J 2005: 24: 324-330.
14. ROBERTS TC, BULLER RS, GAUDREAULT-KEENER M, et al. Effects of storage temperature and time on qualitative and quantitative detection of cytomegalovirus in blood specimens by shell vial culture and PCR. J Clin Microbiol 1997: 35: 2224-2228.
15. SANCHEZ JL, KRUGER RM, PARANJOTHI S, et al. Relationship of cytomegalovirus viral load in blood to pneumonitits in lung transplant recipients. Transplantation 2001: 72: 733-735.
16. HUMAR A, SIEGAL D, MOUSSA G, et al. A prospective assessment of valganciclovir for the treatment of cytomegalovirus infection and disease in transplant recipients. J Infect Dis 2005: 192: 1154-1157.