Bacille Calmette-Guérin intravesical instillation and erectile function: Is there a concern?

Andrologia

Volumn 39, Issue 2, 2007, Pages 51-54

  Sighinolfi, M C ^a   Micali, S ^a   De Stefani, S ^a   Mofferdin, A ^a   Ferrari, N ^a   Giacometti, M ^a   Bianchi, G ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Bacille Calmette Gu rin; Bladder cancer; Erectile dysfunction; Lower urinary tract symptoms

Indexed keywords

BCG VACCINE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLADDER CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ERECTILE DYSFUNCTION; FEMALE; HUMAN; INFECTION; LOWER URINARY TRACT SYMPTOM; MALE; PENIS ERECTION; RISK FACTOR; SCORING SYSTEM; TRANSURETHRAL RESECTION;

ADMINISTRATION, INTRAVESICAL; AGED; BCG VACCINE; CARCINOMA; HUMANS; IMPOTENCE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; URINARY BLADDER NEOPLASMS;

EID: 34147153240     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2007.00762.x     Document Type: Article

References (22)

1. Andius P, Holmäng S (2004) Bacillus Calmette-Guérin therapy in stage Ta/T1 bladder cancer: prognostic factors for time to recurrence and progression. BJU Int 93:980-984.
2. Clavel G, Grados F, Lefauveau P, Fardellone P (2006) Osteoarticular side effects of BCG therapy. Joint Bone Spine 73:24-28.
3. Dederke B, Riecken EO, Weinke T (1998) A case of BCG sepsis with bone marrow and liver involvement after intravesical BCG instillation. Infection 26:54-57.
4. Herr HW, Laudone VP, Badalament RA, Oettgen HF, Sogani PC, Freedman BD, Melamed MR, Whitmore WF Jr (1988) BCG therapy alters the progression of superficial bladder cancer. J Clin Oncol 6:1450-1455.
5. Hurle R, Losa A, Ranieri A, Graziotti P, Lembo A (1996) Low dose Pasteur bacillus Calmette-Guérin regimen in stage T1, grade 3 bladder cancer therapy. J Urol 156:1602-1605.
6. Kamat MR, Kulkarni JN, Tongaonkar HB, Dalal AV (1994) Intravesical bacillus Calmette-Guérin for superficial bladder cancer: experience with Danish 1331 strain. J Urol 152:1424-1428.
7. Krege S, Otto T, Rubben H, Meyer R, Gianni G (1996) Final report on a randomised multicentre trial on adjuvant therapy in superficial bladder cancer. TUR only vs TUR & MMC vs TUR & BCG. J Urol 155:494.
8. Lamm DL (1992) Long-term results of intravesical therapy for superficial bladder cancer. Urol Clin North Am 19:573-580.
9. Leebeek FWG, Ouwendijk RJT, Kolk AHJ, Dees A, Meek JCE, Nienhuis JE, Dingemans-Dumas AM (1996) Granulomatous hepatitis caused by Bacillus Calmette-Guérin (BCG) infection after BCG bladder instillation. Gut 38:616-618.
10. Martinez-Pineiro JA, Jimenez Leon J, Martinez-Pineiro L (1990) Bacillus Calmette-Guérin versus doxorubicin versus thiotepa: a randomised prospective study in 202 patients with superficial bladder cancer. J Urol 143:502-506.
11. McVary KT (2005) Erectile dysfunction and lower urinary tract symptoms secondary to BPH. Eur Urol 47:838-845.
12. Meyer JP, Persad R, Gillatt DA (2002) Use of bacille Calmette- Guérin in superficial bladder cancer. Postgrad Med J 78:449-454.
13. Morales A, Eidinger D, Bruce AW (1976). Intracavitary Bacillus Calmette-Guérin in the treatment of superficial bladder tumors. J Urol 116:180-183.
14. Oosterlink W, van der Meijden A, Sylvester R, Böhle A, Rintala E, Solsona Narvon E, Lobel B. (2006) Guidelines on TaT1 (non-muscle invasive) bladder cancer. European Association of Urology Health Care Office (ed.). Drukkerij Gelderland, Arnhem, The Netherlands, pp. 3-17.
15. Papatsoris AG, Gekas A (2004) Which is the association between erectile dysfunction and lower urinary tract symptoms? Andrologia 36:402-403.
16. Peyromaure M, Guérin F, Amsellem-Ouazana D, Saighi D, Debre B, Zerbib M (2003) Intravesical bacillus Calmette-Guérin therapy for stage T1 grade 3 transitional cell carcinoma of the bladder: recurrence, progression and survival in a study of 57 patients. J Urol 169:2110-2112.
17. Ponholzer A, Temml C, Obermayr R, Madersbacher S (2004) Association between lower urinary tract symptoms and erectile dysfunction. Urology 64:772-776.
18. Rischman P, Desgrandchamps F, Malavaud B, Chopin DK (2000) BCG intravesical instillations: recommendations for side-effect management. Eur Urol 37 (Suppl.):33-36.
19. Shiri R, Hakkinen JT, Hakama M, Huhtala H, Auvinen A, Tammela TL, Koskimaki J (2005) Effect of lower urinary tract symptoms on the incidence of erectile dysfunction. J Urol 174:205-209.
20. Sylvester RJ, van der Meijden AP, Witjes JA, Kurth K (2005) Bacillus Calmette-Guérin versus chemotherapy for the intravesical treatment of patients with carcinoma in situ of the bladder: a meta-analysis of the published results of randomized clinical trials. J Urol 174:86-91.
21. Vegt PDJ, Witjes JA, Witjes WP, Doesburg WH, Debruyne FM, can der Meijden AP (1995) A randomised study of intravesical mitomycin C, BCG-tice and BCG-rivm treatment in pTa, pT1 papillary carcinoma and carcinoma in situ of the bladder. J Urol 153:929-933.
22. Yassin A, Saad F, Hoesl CE, Traish AM, Hammadeh M, Shabsigh R (2006) Alpha-adrenoceptors are a common denominator in the pathophysiology of erectile function and BPH/LUTS - implications for clinical practice. Andrologia 38:1-12.