Characteristics of airflow in a CT-based ovine lung: A numerical study

Journal of Applied Physiology

Volumn 102, Issue 4, 2007, Pages 1469-1482

  Kabilan, Senthil ^a   Lin, Ching Long ^b   Hoffman, Eric A ^a,c  

^a UNIVERSITY OF IOWA   (United States)

^b University of Iowa   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Computational fluid dynamics; Lung gas flow; Monopodial bronchial geometry; Quantitative computed tomography

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BREATHING; COMPUTATIONAL FLUID DYNAMICS; COMPUTER ASSISTED TOMOGRAPHY; EXHALATION; GEOMETRY; INHALATION; LUNG FUNCTION; LUNG MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STUDY; RESPIRATORY AIRFLOW; SHEEP; THREE DIMENSIONAL IMAGING; TRACHEOBRONCHIAL TREE; VALIDITY;

ANIMALS; COMPUTER SIMULATION; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LUNG; MODELS, BIOLOGICAL; PULMONARY VENTILATION; RESPIRATORY MECHANICS; SHEEP; TOMOGRAPHY, X-RAY COMPUTED;

EID: 34147135693     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01219.2005     Document Type: Article

References (22)

1. Balásházy I. Simulation of particle trajectories in bifurcating tubes. J Comput Phys 110: 11-22, 1994.
2. Balásházy I, Hofmann W. Particle deposition in airway bifurcations - inspiratory flow. J Aerosol Sci 24: 745-772, 1993.
3. Balásházy I, Hofmann W. Deposition of aerosols in asymmetric airway bifurcations. J Aerosol Sci 26: 273-292, 1995.
4. Briant JK, Cohen BS. Flow distribution through human and canine airways during inhalation and exhalation. J Appl Physiol 67: 1649-1654, 1989.
5. Caro C. Swirling steady inspiratory flow in models of human bronchial airways (Abstract). Ann Biomed Eng 29: S138, 2001.
6. Chon D, Simon BA, Beck KC, Shikata H, Saba OI, Won C, Hoffman EA. Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studies. Respir Physiol Neurobiol 148: 65-83, 2005.
7. Cohen BS, Briant JK. Flow distribution in human and canine tracheobronchial airway casts. Health Phys 57 Suppl 1: 21-27, 1989.
8. Comer JK, Kleinstreuer C, Hyun S, Kim CS. Aerosol transport and deposition in sequentially bifurcating airways. ASME J Biomech Eng 122: 152-158, 2000.
9. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. 1. Air flow fields. J Fluid Mech 435: 25-54, 2001.
10. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. 2. Aerosol transport and deposition. J Fluid Mech 435: 55-80, 2001.
11. Gatlin B, Cuicchi C, Hammersley J, Olson D, Reddy R, Burnside G. Particle path and wall deposition patterns in laminar flow through a bifurcation, ASME vol. FEDSM97 Vancouver, British Columbia, Canada, 1997, p. 1-6.
12. Guo J, Reinhardt JM, Kitaoka H, Zhang L, Sonka M, McLennan G, Hoffman EA. Integrated system for CT-based assessment of parenchymal lung disease. IEEE Int Symp Biomed Imaging, 2002, p. 871-874.
13. Hoffman EA, Clough AV, Christensen GE, Lin CL, McLennan G, Reinhardt JM, Simon BA, Sonka M, Tawhai MH, van Beek EJ, Wang G. The comprehensive imaging-based analysis of the lung: a forum for team science. Acad Radiol 11: 1370-1380, 2004.
14. Kinsara AA, Tompson RV, Loyalka SK. Computational flow and aerosol concentration profiles in lung bifurcations. Health Phys 64: 13-22, 1993.
15. Lee JW, Goo JH, Chung MK. Characteristics of inertial deposition in a double bifurcation. J Aerosol Sci 27: 119-138, 1996.
16. Lin CL, Lee H, Lee T, Weber LJ. A level set characteristic Galerkin finite element method for free surface flows. Int J Numer Methods Fluids 49: 521-547, 2005.
17. Nowak N, Kakade PP, Annapragada AV. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann Biomed Eng 31: 374-390, 2003.
18. Tajik JK, Kugelmass SD, Hoffman EA. An automated method for relating regional pulmonary structure and function: integration of dynamic multislice CT and thin-slice high-resolution CT. Proc SPIE Med Imaging, 1993, p. 339-350.
19. Tschirren J, Hoffman EA, McLennan G, Sonka M. Airway tree segmentation using adaptive regions of interest. Prog Biomed Optics Imaging 5: 117-124, 2004.
20. Wilquem F, Degrez G. Numerical modeling of steady inspiratory airflow through a three-generation model of the human central airways. ASME J Biomech Eng 119: 59-65, 1997.
21. Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys Fluids 14: 862-880, 2002.
22. Zhang Z, Kleinstreuer C, Kim CS, Hickey AJ. Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors. Inhal Toxicol 14: 1111-1133, 2002.