Exercise improves efficacy of levodopa in patients with Parkinson's disease

Movement Disorders

Volumn 22, Issue 3, 2007, Pages 427-430

  Muhlack, Siegfried ^a   Welnic, Jacub ^a   Woitalla, Dirk ^a   Müller, Thomas ^a  

^a ST JOSEF HOSPITAL   (Germany)

Author keywords

Efficacy; Exercise; Levodopa; Parkinson's disease

Indexed keywords

BENSERAZIDE; DOMPERIDONE; LEVODOPA;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG RESPONSE; EXERCISE; HUMAN; MALE; MOTOR PERFORMANCE; NAUSEA; PARKINSON DISEASE; PRIORITY JOURNAL; TREMOR;

AGED; ANTIPARKINSON AGENTS; AREA UNDER CURVE; EXERCISE; HUMANS; LEVODOPA; MALE; MIDDLE AGED; PARKINSONIAN DISORDERS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 34147135545     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.21346     Document Type: Article

References (10)

1. Ziv I, Avraham M, Michaelov Y, et al. Enhanced fatigue during motor performance in patients with Parkinson's disease. Neurology 1998;51:1583-1586.
2. Carter JH, Nutt JG, Woodward WR. The effect of exercise on levodopa absorption. Neurology 1992;42:2042-2045.
3. Goetz CG, Thelen JA, MacLeod CM, Carvey PM, Bartley EA, Stebbins GT. Blood levodopa levels and unified Parkinson's disease rating scale function: with and without exercise. Neurology 1993;43:1040-1042.
4. Mouradian MM, Juncos JL, Serrati C, Fabbrini G, Palmeri S, Chase TN. Exercise and the antiparkinsonian response to levodopa. Clin Neuropharmacol 1987;10:351-355.
5. Reuter I, Harder S, Engelhardt M, Baas H. The effect of exercise on pharmacokinetics and pharmacodynamics of levodopa. Mov Disord 2000;15:862-868.
6. Müller T, Erdmann C, Bremen D, et al. Impact of gastric emptying on levodopa pharmacokinetics in Parkinson disease patients. Clin Neuropharmacol 2006;29:61-67.
7. Müller T, Woitalla D, Saft C, Kuhn W. Levodopa in plasma correlates with body weight of parkinsonian patients. Parkinsonism Relat Disord 2000;6:171-173.
8. Nauli SM, Maher TJ, Pearce WJ, Ally A. Effects of opioid receptor activation on cardiovascular responses and extracellular monoamines within the rostral ventrolateral medulla during static contraction of skeletal muscle. Neurosci Res 2001;41:373-383.
9. Schad CA, Justice JB, Jr, Holtzman SG. Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. J Pharmacol Exp Ther 2002;300:932-938.
10. Zhu W, Cadet P, Baggerman G, Mantione KJ, Stefano GB. Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol 2005;175:7357-7362.