Inhibition of angiotensin-converting enzyme activity by a partially purified fraction of Gynura procumbens in spontaneously hypertensive rats

Medical Principles and Practice

Volumn 16, Issue 3, 2007, Pages 203-208

  Hoe, See Ziau ^a   Kamaruddin, Mohd Yusof ^a   Lam, Sau Kuen ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Angiotensin converting enzyme, inhibition; Gynura procumbens; Hypotensive

Indexed keywords

ANGIOTENSIN I; ANTIHYPERTENSIVE AGENT; CAPTOPRIL; CYANURIC ACID; DIOXANE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOCONJUGATE; GYNURA PROCUMBENS EXTRACT; HIPPURYLHISTIDYLLEUCINE; PEPTIDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; BIOASSAY; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; COLORIMETRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; HYPOTENSION; IN VITRO STUDY; MEAN ARTERIAL PRESSURE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; QUALITATIVE ANALYSIS; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ASTERACEAE; CAPTOPRIL; HYPERTENSION; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 34147129657     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000100391     Document Type: Article

References (25)

1. Soffer RL: Angiotensin-converting enzyme and the regulation of vasoactive peptides. Ann Rev Biochem 1976;45:73-94.
2. Kim S, Iwao H: Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 2000;52:11-34.
3. Erdox EG: The angiotensin I converting enzyme. Fed Proc 1977;36:1760-1765.
4. Vanhoutte DM: Endothelium and control of vascular function: state of the art lecture. Hypertension 1989;13:658-667.
5. Stein JH, Congbalay RC, Karsh DL, Osgood RW, Ferris TF: The effect of bradykinin on proximal tubular sodium reabsorption in the dogs: evidence for functional nephron heterogeneity. J Clin Invest 1972;51:1709-1721.
6. Wong J, Patel RA, Kowey PR: The clinical use of angiotensin-converting enzyme inhibitors. Prog Cardiovasc Dis 2004;47:116-130.
7. Liu JC, Hsu FL, Tsai JC, Chan P, Liu JYH, Thomas GN, Tomlison B, Lo MY, Lin JY: Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiotensin converting enzyme. Life Sci 2003;73:1543-1555.
8. Kameda K, Takaku T, Okuda H, Kimura Y, Okuda T, Hatano T, Agata I, Arichi S: Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod 1987;50:680-683.
9. Yang Y, Marczak ED, Yokoo M, Usui H, Yoshikawa, M: Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco. J Agric Food Chem 2003;51:4897-4902.
10. Motoi H, Kodama T: Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung 2003;47:352-356.
11. Suetsuna K, Maekawa K, Chen JR: Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J Nutr Biochem 2004;15:267-272.
12. Perry LM: Medicinal Plants of East and Southeast Asia. Attributed Properties and Uses. Cambridge, MIT Press, 1980.
13. Hoe SZ, Lam SK: Hypotensive activity of an aqueous fraction of Gynura procumbens and possible mechanisms of action. Circ J 2005;69(suppl 1):348.
14. Hurst PL, Lovell-Smith CJ: Optimized assay for serum angiotensin- converting enzyme activity. Clin Chem 1981;27:2048-2052.
15. Houghton PJ, Raman A: Laboratory Handbook for the Fractionation of Natural Extracts. London, Chapman & Hall, 1998.
16. Anderson K, Li SC, Li YT: Diphenylamineaniline-phosphoric acid reagent, a versatile spray reagent for revealing glycoconjugates on thin layer chromatography plates. Anal Biochem 2000;287:337-339.
17. Cushman DW, Ondetti MA: History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 1991;17:589-592.
18. Brown NJ, Vaughan DE: Angiotensin-converting enzyme inhibitors. Circulation 1998;97:1411-1420.
19. Christen Y, Waeber B, Nussberger J, Porchet M, Borland RM, Lee RJ, Maggon K, Shum L, Timmermans PB, Brunner HR: Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers: inhibition of pressor response to exogenous angiotensin I and II. Circulation 1991;83:1333-1342.
20. Rutherfurd-Markwick KJ, Moughan PJ: Bioactive peptides derived from food. J AOAC Int 2005;88:955-966.
21. Saito Y, Wanezaki K, Kawato A, Imayasu S: Antihypertensive effects of peptide in sake and its by-products on spontaneously hypertensive rats. Biosci Biotechnol Biochem 1994;58:812-816.
22. Kuba M, Tanaka K, Tawata S, Takeda Y, Yasuda M: Angiotensin I-converting enzyme inhibitory peptides isolated from tofuyo fermented soybean food. Biosci Biotechnol Biochem 2003;67:1278-1283.
23. Marczak ED, Usui H, Fujita H, Yang Y, Yokoo M, Lipkowski AW, Yoshikawa M: New antihypertensive peptides isolated from rapeseed. Peptides 2003;24:791-798.
24. Megias C, del Mar Yust M, Pedroche J, Lquari H, Giron-Calle J, Alaiz M, Millan F, Vioque J: Purification of an ACE inhibitory peptide after hydrolysis of sunflower (Helianthus annuus L.) protein isolates. J Agric Food Chem 2004;52:1928-1932.
25. Ondetti MA, Williams NJ, Sabo EF, Pluscec J, Weaver ER, Kocy O: Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca: isolation, elucidation of structure, and synthesis. Biochemistry 1971;10:4033-4039.