Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 4, 2007, Pages 846-854

  Staton, C A ^a   Stribbling, S M ^a   Garcia Echeverria C ^b   Bury, J P ^a   Tazzyman, S ^a   Lewis, C E ^a   Brown, Nicola J ^a,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Alphastatin; Anti endothelial; Fibrinogen; Thrombosis; Tumor

Indexed keywords

AHN 419; ALANINE; ALPHASTATIN; AMINO ACID; ANTINEOPLASTIC AGENT; ARGININE; ASPARTYLPHENYLALANYLLEUCYLALANYLGLUTAMYLGLYCYLGLYCYLGLYCYLVALYLARGINYLGLYCINE; GLYCINE; GROWTH FACTOR; LEUCINE; PHENYLALANINE; PROLINE; SERINE; UNCLASSIFIED DRUG; VALINE;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CELL MIGRATION; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; FIBRINOGEN; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; MUTATION;

EID: 34147123805     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02432.x     Document Type: Article

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