Usage of the T1 effect of an iron oxide contrast agent in an animal model to quantify myocardial blood flow by MRI

European Journal of Radiology

Volumn 62, Issue 2, 2007, Pages 247-256

  Lüdemann, Lutz ^b   Schmitt, Boris ^a   Podrabsky, Petr ^b   Schnackenburg, Bernhard ^c   Böck, Johannes ^b   Gutberlet, Matthias ^b  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c PHILIPS HEALTHCARE   (United States)

Author keywords

Blood flow; Blood volume; Contrast media; Magnetic resonance imaging; Perfusion

Indexed keywords

BLOOD VESSELS; ECHOCARDIOGRAPHY; HEMODYNAMICS; IRON OXIDES; MAGNETIC RESONANCE IMAGING; REGRESSION ANALYSIS;

BLOOD VOLUME; MYOCARDIAL BLOOD FLOW (MBF); PERFUSION; REGIONAL MYOCARDIAL BLOOD FLOW (RMBF);

CONTRAST MEDIA;

ADENOSINE; CONTRAST MEDIUM; MICROSPHERE; NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE; DIAGNOSTIC AGENT; FERRIC ION; FERRIC OXIDE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRAST ENHANCEMENT; CORONARY ARTERY OBSTRUCTION; DOSE CALCULATION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE PERFUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SWINE; VASODILATATION; ANALYSIS OF VARIANCE; ANIMAL; BALLOON OCCLUSION; BLOOD FLOW VELOCITY; CORONARY ARTERY BLOOD FLOW; DISEASE MODEL; DRUG EFFECT; HEART MUSCLE; HEART VENTRICLE; IMAGE ENHANCEMENT; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; STATISTICAL MODEL; TIME;

ADENOSINE; ANALYSIS OF VARIANCE; ANIMALS; BALLOON OCCLUSION; BLOOD FLOW VELOCITY; CONTRAST MEDIA; CORONARY CIRCULATION; CORONARY STENOSIS; DISEASE MODELS, ANIMAL; FERRIC COMPOUNDS; HEART VENTRICLES; IMAGE ENHANCEMENT; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MICROSPHERES; MYOCARDIUM; RESEARCH DESIGN; SWINE; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 34147111932     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2006.12.002     Document Type: Article

References (42)

1. Schwartz J.G., Johnson R.B., Aepfelbacher F.C., et al. Sensitivity, specificity and accuracy of stress SPECT myocardial perfusion imaging for detection of coronary artery disease in the distribution of first-order branch vessels, using an anatomical matching of angiographic and perfusion data. Nucl Med Commun 24 (2003) 543-549
2. Gewirtz H., Fischman A.J., Abraham S., Gilson M., Strauss H.W., and Alpert N.M. Positron emission tomographic measurements of absolute regional myocardial blood flow permits identification of nonviable myocardium in patients with chronic myocardial infarction. J Am Coll Cardiol 23 (1994) 851-859
3. Pirich C., Leber A., Knez A., et al. Relation of coronary vasoreactivity and coronary calcification in asymptomatic subjects with a family history of premature coronary artery disease. Eur J Nucl Med Mol Imaging 31 (2004) 663-670
4. Jerosch-Herold M., Swingen C., and Seethamraju R.T. Myocardial blood flow quantification with MRI by model-independent deconvolution. Med Phys 29 (2002) 886-897
5. Schmitt M., Viallon M., Thelen M., and Schreiber W.G. Quantification of myocardial blood flow and blood flow reserve in the presence of arterial dispersion: a simulation study. Magn Reson Med 47 (2002) 787-793
6. Vallee J.P., Sostman H.D., MacFall J.R., and Coleman R.E. Quantification of myocardial perfusion with MRI and exogenous contrast agents. Cardiology 88 (1997) 90-105
7. Al-Saadi N., Gross M., Bornstedt A., et al. Comparison of various parameters for determining an index of myocardial perfusion reserve in detecting coronary stenosis with cardiovascular magnetic resonance tomography. Z Kardiol 90 (2001) 824-834
8. Canet E.P., Janier M.F., and Revel D. Magnetic resonance perfusion imaging in ischemic heart disease. J Magn Reson Imaging 10 (1999) 423-433
9. Jerosch-Herold M., Wilke N., Wang Y., et al. Direct comparison of an intravascular and an extracellular contrast agent for quantification of myocardial perfusion. Cardiac MRI Group. Int J Card Imaging 15 (1999) 453-464
10. Tofts P.S., Brix G., Buckley D.L., et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10 (1999) 223-232
11. Christian T.F., Rettmann D.W., Aletras A.H., et al. Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology 232 (2004) 677-684
12. Wacker C.M., and Bauer W.R. Myocardial microcirculation in humans-new approaches using MRI. Herz 28 (2003) 74-81
13. Hamm B., Staks T., Taupitz M., et al. Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. J Magn Reson Imaging 4 (1994) 659-668
14. Kety S.S. Theory of blood-tissue exchange and its application to measurement of blood flow. Methods Med Res 8 (1960) 223-227
15. Kety S.S., and Schmidt C.F. The nitrous oxide method for the quantitative determination of cerebral blood flow in man. Theory, procedure and normal values. J Clin Invest 27 (1948) 476-483
16. Rosen B.R., Belliveau J.W., Vevea J.M., and Brady T.J. Perfusion imaging with NMR contrast agents. Magn Reson Med 14 (1990) 249-265
17. Carme SW, Wiart M, Larsson M, Neyran B, Canet-Soulas, E. Effects of water exchange on MR quantification of regional myocardial blood flow using an intravascular T1 contrast agent. Paper presented at the ISMRM Twelfth Scientific Meeting, Kyoto; 2004.
18. Donahue K.M., Weisskoff R.M., Parmelee D.J., et al. Dynamic Gd-DTPA enhanced MRI measurement of tissue cell volume fraction. Magn Reson Med 34 (1995) 423-432
19. Wendland M.F., Saeed M., Yu K.K., et al. Inversion recovery EPI of bolus transit in rat myocardium using intravascular and extravascular gadolinium-based MR contrast media: dose effects on peak signal enhancement. Magn Reson Med 32 (1994) 319-329
20. Schmitt M., Horstick G., Petersen S., et al. Quantification of resting myocardial blood flow in a pig model of acute ischemia based on first-pass MRI. Magn Reson Med 53 (2005) 1223-1227
21. du Toit E., Hofmann D., McCarthy J., and Pineda C. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart 86 (2001) 81-87
22. Yip G., Khandheria B., Belohlavek M., et al. Strain echocardiography tracks dobutamine-induced decrease in regional myocardial perfusion in nonocclusive coronary stenosis. J Am Colloid Cardiol 44 (2004) 1664-1671
23. Lindner K.H., Prengel A.W., Pfenninger E.G., et al. Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs. Circulation 91 (1995) 215-221
24. Altura B.M., and Halevy S. Cardiovascular actions of anesthetics and drugs used in aesthesia vols. I and II (1986), Kager, Basel
25. Doenicke A. Etomidate: Anästesiologie und Wiederbelebung vol. 106 (1977), Springer, Berlin
26. Schüttler J., Stoeckel H., Wilms M., Schwilden H., and Lauven P.M. Infusion model for etomidate. Anaesthesist 29 12 (1980) 662-666
27. Duman A., Saide Sahin A., Esra Atalik K., et al. The in vitro effects of remifentanil and fentanyl on isolated human right atria and saphenous veins. J Cardiothorac Vasc Anesth 17 (2003) 465-469
28. Yellon D.M., and Downey J.M. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 83 4 (2003) 1113-1151
29. Raeburn C.D., Zimmerman M.A., Arya J., Barsness K., and Harken A.H. Ischemic preconditioning: fact or fantasy?. J Card Surg 17 (2002) 536-542
30. Kowallik P., Schulz R., Guth B.D., et al. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 83 (1991) 974-982
31. Grund F., Sommerschild H.T., Lyberg T., Kirkeboen K.A., and Ilebekk A. Microembolization in pigs: effects on coronary blood flow and myocardial ischemic tolerance. Am J Physiol 277 2 Pt 2 (1999) H533-H542
32. Millard R.W., Baig H., and Vatner S.F. Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions. Am J Physiol 232 3 (1977) H331-H334
33. Crnac J., Schmidt M.C., Theissen P., and Sechtem U. Assessment of myocardial perfusion by magnetic resonance imaging. Herz 22 (1997) 16-28
34. Jerosch Herold M., Hu X., Murthy N.S., Rickers C., and Stillman A.E. Magnetic resonance imaging of myocardial contrast enhancement with MS-325 and its relation to myocardial blood flow and the perfusion reserve. J Magn Reson Imaging 18 (2003) 544-554
35. Kraitchman D.L., Wilke N., Hexeberg E., et al. Myocardial perfusion and function in dogs with moderate coronary stenosis. Magn Reson Med 35 (1996) 771-780
36. Machnig T., Koroneos A., Engels G., et al. Quantitative evaluation of myocardial perfusion with ultrafast magnetic resonance tomography. Z Kardiol 83 (1994) 840-850
37. Canet E., Revel D., Forrat R., et al. Superparamagnetic iron oxide particles and positive enhancement for myocardial perfusion studies assessed by subsecond T1-weighted MRI. Magn Reson Imaging 11 (1993) 1139-1145
38. Canet E., Revel D., Sebbag L., et al. Noninvasive assessment of no-reflow phenomenon in a canine model of reperfused infarction by contrast-enhanced magnetic resonance imaging. Am Heart J 130 (1995) 949-956
39. Lombardi M., Jones R.A., Westby J., et al. Use of the mean transit time of an intravascular contrast agent as an exchange-insensitive index of myocardial perfusion. J Magn Reson Imaging 9 (1999) 402-408
40. Revel D., Canet E., Sebbag L., et al. First-pass and delayed magnetic resonance imaging studies of reperfused myocardial infarction with iron oxide particles. Acad Radiol 3 Suppl. 2 (1996) S398-S401
41. Taupitz M., Schnorr J., Wagner S., et al. Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium. Radiology 222 (2002) 120-126
42. Wagner S., Schnorr J., Pilgrimm H., Hamm B., and Taupitz M. Monomer-coated very small superparamagnetic iron oxide particles as contrast medium for magnetic resonance imaging: preclinical in vivo characterization. Invest Radiol 37 (2002) 167-177