Risperidone-induced reduction in JC viruria as a surrogate marker for efficacy against progressive multifocal leukoencephalopathy and hemorrhagic cystitis

Journal of Clinical Virology

Volumn 39, Issue 1, 2007, Pages 63-64

  Focosi, Daniele ^a   Kast, Richard Eric ^b   Maggi, Fabrizio ^c   Ceccherini Nelli, Luca ^c   Petrini, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c Retrovirus Center   (Italy)

Author keywords

5 HT2a antagonists; Hemorrhagic cystitis; JC viruria; JC virus; PML; Progressive multifocal leukoencephalopathy; Risperidone

Indexed keywords

CYTOCHROME P450 2D6; HYALURONIC ACID; RISPERIDONE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; ZIPRASIDONE;

BINDING AFFINITY; BLOOD BRAIN BARRIER; DISEASE MARKER; DRUG BINDING; DRUG METABOLISM; DRUG WITHDRAWAL; HEMORRHAGIC CYSTITIS; HUMAN; IMMUNOCOMPETENCE; JC VIRUS; LETTER; LOW DRUG DOSE; MONOTHERAPY; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; QUANTITATIVE ANALYSIS;

CYSTITIS; HEMORRHAGE; HUMANS; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; POLYOMAVIRUS INFECTIONS; RISPERIDONE;

EID: 34147111788     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2007.03.001     Document Type: Letter

References (10)

1. Altschuler E., and Kast R. The atypical antipsychotic agents ziprasidone [correction of zisprasidone], risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Med Hypotheses 65 (2005) 585-586
2. Boldorini R., Veggiani C., and Barco D.G. Kidney and urinary tract polyomavirus infection and distribution: molecular biology investigation of 10 consecutive autopsies. Arch Pathol Lab Med 129 (2005) 69-73
3. Chang H., Wang M., Tsai R., Lin H., Huan J., Wang W., et al. High incidence of JC viruria in JC-seropositive older individuals. J Neurovirol 8 (2002) 447-451
4. Elphick G.F., Querbes W., Jordan J.A., Gee G.V., Eash S., Manley K., et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science 306 (2004) 1380-1383
5. Focosi D., and Kast R.E. Hyaluronate and risperidone for hemorrhagic cystitis. Bone Marrow Transplant 39 (2007) 57
6. Focosi D., Fazzi R., Montanaro D., Emdin M., and Petrini M. Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: a clinical, neuroradiological and virological response after treatment with risperidone. Antivir Res 74 2 (2007) 156-158
7. Hernandez M., Barahona M., Simonsen U., Recio P., Rivera L., Martinez A., et al. Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter. Br J Pharmacol 138 (2003) 137-144
8. Kast, R. JC viruria eradication by risperidone in a woman with meningioma. Antivir Res, in press.
9. Mannens G., Huang M., Meuldermans W., Hendrickx J., Woestenborghs R., and Heykants J. Absorption, metabolism, and excretion of risperidone in humans. Drug Metab Dispos 21 (1993) 1134-1141
10. Moret H., Brodard V., Barranger C., Jovenin N., Joannes M., and Andreoletti L. New commercially available PCR and microplate hybridization assay for detection and differentiation of human polyomaviruses JC and BK in cerebrospinal fluid, serum, and urine samples. J Clin Microbiol 44 (2006) 1305-1309