Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen [3]

Blood

Volumn 109, Issue 8, 2007, Pages 3608-3609

  Bougie, Daniel W ^a   Benito, Ana I ^b   Sanchez Abarca, Luis I ^b   Torres, Ricardo ^b   Birenbaum, Jessica ^b   Aster, Richard H ^b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; FIBRINOGEN RECEPTOR; GLUCURONIDE; GLYCOPROTEIN IB; IMMUNOGLOBULIN G ANTIBODY; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PARACETAMOL SULFATE; PREDNISONE;

CASE REPORT; CLINICAL FEATURE; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; IMMUNOPRECIPITATION; LETTER; PRESCHOOL CHILD; PRIORITY JOURNAL; THROMBOCYTOPENIA;

EID: 34147100196     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-12-063941     Document Type: Letter

References (10)

1. Bougie D, Aster R. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood. 2001;97:3846-3850.
2. Eisner EV, Shahidi NT. Immune thrombocytopenia due to a drug metabolite. N Engl J Med. 1972;287:376-381.
3. Eisner EV, Kasper K. Immune thrombocytopenia due to a metabolite of para-amino-salicylic acid. Am J Med. 1972;53:790-796.
4. Salama A, Mueller-Eckhardt C. The role of metabolite-specific antibodies in nomifensine-dependent immune hemolytic anemia. N Engl J Med. 1985;313:469-474.
5. Kiefel V, Santoso S, Schmidt S, Salama A, Mueller-Eckhardt C. Metabolite-specific (IgG) and drug-specific antibodies (IgG, IgM) in two cases of trimethoprim-sulfamethoxazole-induced immune thrombocytopenia. Transfusion. 1987;27:262-265.
6. Cunha PD, Lord RS, Johnson ST, et al. Immune hemolytic anemia caused by sensitivity to a metabolite of etodolac, a nonsteroidal anti-inflammatory drug. Transfusion. 2000;40:663-668.
7. Bougie D, Johnson ST, Weitekamp LA, Aster RH. Sensitivity to a metabolite of diclofenac as a cause of acute immune hemolytic anemia. Blood. 1997;90:407-413.
8. Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ. Bioactivation by glucuronide-conjugate formation. Adv Pharmacol. 1994;27:385-397.
9. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995;1:2-4.
10. de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Glucuronidation in humans: pharmacogenetic and developmental aspects. Clin Pharmacokinet. 1999;36:439-452.