Association of the 5-HT2A receptor gene polymorphism 102T/C with ischemic stroke

Journal of Molecular Neuroscience

Volumn 30, Issue 3, 2006, Pages 323-328

  Olesen, Ole F ^a   Bennike, Bente ^a   Dam, Henrik ^a   Mellerup, Erling ^a  

^a Rigshospitalet   (Denmark)

Author keywords

102T C; 5 HT2A receptor; Ischemic stroke; Polymorphism

Indexed keywords

SEROTONIN 2A RECEPTOR;

ADULT; ALLELE; ARTICLE; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; RECEPTOR GENE; RISK ASSESSMENT; RISK FACTOR;

BRAIN ISCHEMIA; CHI-SQUARE DISTRIBUTION; CYTOSINE; DNA; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; REFERENCE VALUES; SEQUENCE DELETION; THYMINE;

EID: 34147093674     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:30:3:323     Document Type: Article

References (19)

1. Arias B., Gasto C., Catalan R., Gutierrez B., Pintor L., and Fasanas L. (2001) The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. Am. J. Med. Genet. 105, 801-804.
2. Arranz M., Collier D., Sodhi M., et al. (1995) Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet 346, 281-282
3. Bak S., Gaist D., Sindrup S. H., Skytthe A., and Christensen K. (2002) Genetic liability in stroke: a long-term follow-up study of Danish twins. Stroke 33, 769-774.
4. Casas J. P., Hingorani A. D., Bautista L. E., and Sharma P. (2004) Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch. Neurol. 61, 1652-1661.
5. Fitzgerald D. J., Roy L., Catella F., and Fitzgerald G. A. (1986) Platelet activation in unstable coronary artery disease. N. Engl. J. Med. 315, 983-989.
6. Hoyer D., Clarke D. E., Fozard J. R., et al. (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46, 157-203.
7. Ketanserin Trial Group (1989) Prevention of atherosclerotic complications: controlled trial of ketanserin. Br. Med. J. 298, 424-430.
8. Kusumi I., Suzuki, K., Sasaki Y., Kameda K., Sasaki T., and Koyama T. (2002) Serotonin 5-HT2Areceptor function and personality traits in healthy subjects: a negative. J. Affect. Disord. 68, 235-241.
9. Liolitsa D., Powell J. F., Prince M., and Lovestone S. (2001) Association study of the 5-HT(2A) receptor gene polymorphism T102C and essential hypertension. J. Hum. Hypertens. 15, 335-339.
10. Parsons M. J., D'Souza U. M., Arranz M-J., Kerwin R. W., and Makoff A. J. (2004) The -1438A/G polymorphism in the 5-hydroxytryptamine type 2Areceptor gene affects promoter activity. Biol. Psychiatry 56, 406-410.
11. Polesskaya O. O. and Sokolov B. P. (2002) Differential expression of the C and T alleles of the 5-HT2A receptor gene in temporal cortex or normal individuals and schizophrenics. J. Neurosci. Res. 67, 812-822.
12. Rosmond R., Bouchard C., and Björntorp P. (2002) Increased Abdominal Obesity in Subjects with a Mutation in the 5-HT2A Receptor Gene Promoter. Ann. N.Y. Acad. Sci. 967, 571-575.
13. Rothe C., Koszycki D., Bradwejn N. K., et al. (2004) Association study of serotonin-2Areceptor gene polymorphism and panic disorder in patients from Canada and Germany. Neurosci. Lett. 363, 276-279.
14. Spurlock G., Heils P., Holmans P., et al. (1998) A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol. Psychiatr. 3, 42-49.
15. Thulesius O., Lundvall, J., Kroese A., et al. (1987) Ketanserin in intermittent claudication: effect on walking distance, blood pressure, and cardiovascular complications. J. Cardiovasc. Pharmacol. 9, 728-733.
16. Vanhoutte P., Amery A., Birkenhager W., et al. (1988) Serotonergic mechanisms in hypertension. Focus on the effects of ketanserin. Hypertension 11, 111-133.
17. Yamada S., Akita H., Kanazawa K., et al. (2000) T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction. Artherosclerosis 150, 143-148.
18. Yu B., Wang A., Zhou G., et al. (2004) T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls. Clin. Exp. Pharm. Phys. 31, 847-849.
19. Zhang L., Ma W., Barker J. L., and Rubinow D. R. (1999) Sex differences in expression of serotonin receptors (subtypes 1A and 2A) in rat brain : a possible role of testosterone. Neuroscience 94, 251-259.