Co-administration of Na-EDTA and Diminazene Aceturate (DA) to Mice Infected with DA-resistant Trypanosoma brucei

Journal of Comparative Pathology

Volumn 136, Issue 2-3, 2007, Pages 206-211

  Ihedioha, J I ^a   Ochiogu, I S ^b   Ihedioha, T E ^c  

^a Departments of Veterinary Pathology and Microbiology

^b Veterinary Obstetrics and Reproductive Diseases

^c UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

diminazene aceturate; mouse; Na EDTA; parasitic infection; Trypanosoma brucei

Indexed keywords

DIMINAZENE ACETURATE; EDETATE SODIUM; NOZOMIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL PARASITOSIS; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; EXPERIMENTAL INFECTION; HEMATOCRIT; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

ANEMIA; ANIMALS; CHELATING AGENTS; DIMINAZENE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EDETIC ACID; HEMATOCRIT; LONGEVITY; MALE; MICE; PARASITEMIA; PARASITIC DISEASES, ANIMAL; SURVIVAL RATE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

MUS; TRYPANOSOMA BRUCEI;

EID: 34047276465     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2007.01.003     Document Type: Article

References (27)

1. Egbe-Nwiyi T.N., Igbokwe I.O., and Onyeyili P.A. The pathogenicity of diminazene aceturate-resistant Trypanosoma brucei in rats after treatment with the drug. Journal of Comparative Pathology 128 (2003) 188-191
2. Eisler M.C., Brandt J., Bauer B., Clausen P.H., Delespaux V., Holmes P.H., Ilemobade A., Machila N., Mbwambo H., McDermoh J., Mehlitz D., Murilla G., Ndungu J.M., Peregrine A.S., Sidibe I., Sinyangwe L., and Geerts S. Standardised tests in mice and cattle for the detection of drug resistance in tsetse transmitted trypanosomes of African domestic cattle. Veterinary Parasitology 97 (2001) 171-183
3. Geerts, S. and Holmes, P.H. (1998). Drug management and parasite clearance in bovine trypanosomiasis in Africa. The Programme Against African Trypanosomiasis (PAAT), Technical and Scientific Series I, FAO, Rome, pp. 5-31.
4. Herbert W.J., and Lumsden W.H. Trypanosoma brucei: a rapid matching method for estimating the host parasitaemia. Experimental Parasitology 40 (1976) 427-431
5. Herman R., and Baron S. Immunologic-mediated protection of Trypanosoma congolense-infected mice by polyribonucleotides. Journal of Protozoology 18 (1971) 661-664
6. Hininger I., Waters R., Osman M., Garrel C., Fernholz K., Roussel A.M., and Anderson R.A. Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy. Free Radical Biology and Medicine 38 (2005) 1565-1570
7. Holmes P.H., Eisler M.C., and Geerts S. Current chemotherapy of animal trypanosomiasis. In: Maudlin I., Holmes P.H., and Miles M.A. (Eds). The Trypanosomiases (2004), CAB International, Wallingford 431-444
8. Horst S.H.S. Trypanosomosis. In: Horst S.H.S. (Ed). Tropical Animal Health (1996), Kluwer Academic Publishers, Dordrecht 152-169
9. Lamas G.A., and Hussein S.J. EDTA chelation therapy meets evidence-based medicine. Complementary Therapies in Clinical Practice 12 (2006) 213-215
10. Lambert R.J.W., Hanlon G.W., and Denyer S.P. The synergistic effect of EDTA/antimicrobial combinations on Pseudomonas aeruginosa. Journal of Applied Microbiology 96 (2004) 244-249
11. Leach T.M., and Roberts C.J. Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the Eastern hemisphere. Pharmacology and Therapeutics 13 (1981) 91-147
12. Leive L. A non-specific increase in permeability in Escherichia coli produced by EDTA. Proceedings of the National Academy of Sciences of the USA 53 (1968) 745-750
13. MacAdams R.F., and Williamson J. Drug effects on the fine structure of Trypanosoma rhodesiense: diamidines. Transactions of the Royal Society of Tropical Medicine and Hygiene 66 (1972) 897-904
14. Murray M., and Morrison W.I. Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants. Parasitology 79 (1979) 349-366
15. Murray M., Murray P.K., and McIntyre W.I.M. An improved parasitological technique for the diagnosis of African trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 71 (1977) 325-326
16. Newton B.A. Recent studies on the mechanism of action of Berenil (diminazene) and related compounds. In: Van den Bossche H. (Ed). Comparative Biochemistry of Parasites (1972), Academic Press, New York 127-133
17. Nyindo M. Animal Diseases due to Protozoa and Rickettsia (1992), English Press, Nairobi, Kenya pp. 1-37
18. PAAT (2001). Facts and figures on African trypanosomosis. Programme Against African Trypanosomosis (PAAT) Newsletter, 10, 5-7.
19. Peregrine A.S., and Mamman M. Pharmacology of diminazene: a review. Acta Tropica 54 (1993) 185-203
20. Shaw A.P.M. Economics of African trypanosomiasis. In: Maudlin I., Holmes P.H., and Miles M.A. (Eds). The Trypanosomiases (2004), CAB International, Wallingford 369-402
21. Singer I., Kimble E.T., and Rilts R.E. Alterations in host-parasite relationship by the administration of endotoxins to mice infected with trypanosomes. Journal of Infectious Diseases 114 (1964) 243-248
22. Taylor K., and Authie E.M.L. Pathogenesis of animal trypanosomiasis. In: Maudlin I., Holmes P.H., and Miles M.A. (Eds). The Trypanosomiases (2004), CAB International, Wallingford 331-353
23. USFDA (2005). Maximum recommended therapeutic dose (MRTD) database-EDTA (edetic acid). United States Food and Drug Administration (USFDA), Center for Drug Evaluation and Research, USA.
24. Van den Bossche P., and Doran M. Trypanocidal Drugs: Use and Misuse? Regional Tsetse and Trypanosomiasis Control Programme (2004), Harare, Zimbabwe
25. Wooley R.E., and Jones M.S. Action of EDTA-Tris and antimicrobial agent combinations on selected pathogenic bacteria. Veterinary Microbiology 8 (1983) 271-280
26. Wooley R.E., Jones M.S., Gilbert J.P., and Shotts Jr. E.B. In vitro action of combinations of antimicrobial agents and EDTA-tromethamine on Escherichia coli. American Journal of Veterinary Research 44 (1983) 1154-1158
27. Yuan D., and Shen V. Stability of ribosomal and transfer ribonucleic acid in Escherichia coli B/V after treatment with ethylene dinitrilotetraacetic acid and rafampin. Journal of Bacteriology 122 (1975) 425-432