Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 1, 2007, Pages 137-143

  McEvoy, Eamon ^a   Donegan, Sheila ^a   Power, Joe ^a   Altria, Kevin ^b  

^a Ireland   (Ireland)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acetaminophen; Gradient elution; Microemulsion liquid chromatography; Paracetamol; Related substances; Suppository; Validation

Indexed keywords

ACETONITRILE; BUTANE; OCTANE; PARACETAMOL; PROPANOL;

ARTICLE; DRUG DETERMINATION; DRUG FORMULATION; DRUG ISOLATION; DRUG SOLUBILITY; HYDROPHOBICITY; LIQUID CHROMATOGRAPHY; MICROEMULSION; PRIORITY JOURNAL; SUPPOSITORY; VALIDATION PROCESS;

ACETAMINOPHEN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; GREAT BRITAIN; HYDROPHOBICITY; OILS; PHARMACOPOEIAS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLUBILITY; SUPPOSITORIES; TIME FACTORS; WATER;

EID: 34047267312     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.02.025     Document Type: Article

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