Neural Responses to Facial Expressions of Disgust but not Fear are Modulated by Washing Symptoms in OCD

Biological Psychiatry

Volumn 61, Issue 9, 2007, Pages 1072-1080

  Lawrence, Natalia S ^a   An, Suk Kyoon ^a   Mataix Cols, David ^a   Ruths, Florian ^a   Speckens, Anne ^a   Phillips, Mary L ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Disgust; facial expressions; fMRI; Obsessive Compulsive Disorder; symptom dimensions; washing symptoms

Indexed keywords

BUSPIRONE; CITALOPRAM; CLOMIPRAMINE; FLUOXETINE; FLUVOXAMINE; PAROXETINE; VENLAFAXINE; ZOPICLONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTIONALITY; FACIAL EXPRESSION; FEAR; FEMALE; HUMAN; MALE; NERVE POTENTIAL; NEUROIMAGING; OBSESSIVE COMPULSIVE DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ADULT; BRAIN; BRAIN CHEMISTRY; EXPRESSED EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; OBSESSIVE-COMPULSIVE DISORDER; OXYGEN CONSUMPTION; PSYCHIATRIC STATUS RATING SCALES;

EID: 34047262695     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.06.033     Document Type: Article

References (46)

1. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
2. Breiter H.C., Etcoff N.L., Whalen P.J., Kennedy W.A., Rauch S.L., Buckner R.L., et al. Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17 (1996) 875-887
3. Calder A.J., Young A.W., Rowland D., and Perrett D.I. Computer-enhanced emotion in facial expressions. Proc R Soc Lond B 264 (1997) 919-925
4. Calder A.J., Lawrence A.D., and Young A.W. Neuropsychology of fear and loathing. Nat Rev Neurosci 2 (2001) 352-363
5. Cannistraro P.A., Wright C.I., Wedig M.M., Martis B., Shin L.M., Wilhelm S., and Rauch S.L. Amygdala responses to human faces in obsessive-compulsive disorder. Biol Psychiatry 56 (2004) 916-920
6. Cox R. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29 (1996) 162-173
7. Critchley H.D., Wiens S., Rotshtein P., Öhman A., and Dolan R.J. Neural systems supporting interoceptive awareness. Nature Neurosci 7 (2004) 189-195
8. Ekman P., and Friesen W. Pictures of facial affect (1976), Consulting Psychologists Press, Palo Alto
9. First M.B., Gibbon M., Spitzer R.L., Williams J.B.W., and Smith B.L. Structured Clinical Interview for DSM-IV Axis II Disorders-Patient Edition (1995), Biometrics Research Dept, New York State Psychiatric Institute, New York
10. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (1995), Biometrics Research Dept, New York State Psychiatric Institute, New York
11. Fitzgerald D.A., Posse S., Moore G.J., Tancer M.E., Nathan P.J., and Phan K.L. Neural correlates of internally-generated disgust via autobiographical recall: a functional magnetic resonance imaging investigation. Neurosci Lett 370 (2004) 91-96
12. Foa E.B., Huppert J.D., Leiberg S., Langner R., Kichic R., Hajcak G., and Salkovskis P.M. The Obsessive-Compulsive Inventory: development and validation of a short version. Psychol Assess 14 (2002) 485-496
13. Friedlander L., and Desrocher M. Neuroimaging studies of obsessive-compulsive disorder in adults and children. Clin Psychol Rev 26 (2006) 32-49
14. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., and Charney D.S. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), part I: development, use and reliability. Arch Gen Psychiatry 46 (1989) 1006-1011
15. Haidt J., McCauley C., and Rozin P. Individual differences in sensitivity to disgust: A scale sampling seven domains of disgust elicitors. Pers Indiv Diff 16 (1994) 701-713
16. Lange K., Williams L.M., Young A.W., Bullmore E.T., Brammer M.J., Williams S.C., et al. Task instructions modulate neural responses to fearful facial expressions. Biol Psychiatry 53 (2003) 226-232
17. Mancini F., Gragnani A., and D'Olimpio F. The connection between disgust and obsessions and compulsions in a non-clinical sample. Pers Indiv Diff 31 (2001) 1173-1180
18. Mataix-Cols D., Wooderson S., Lawrence N., Brammer M.J., Speckens A., and Phillips M.L. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 61 (2004) 564-576
19. McNally R.J. Disgust has arrived. J Anxiety Disord 16 (2002) 561-566
20. Merboldt K.D., Fransson P., Bruhn H., and Frahm J. Functional MRI of the human amygdala?. Neuroimage 14 (2001) 253-257
21. Modell J.G., Mountz J.M., Curtis G.C., and Greden J.F. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1 (1989) 27-36
22. Morris J.S., Frith C.D., Perrett D.I., Rowland D., Young A.W., Calder A.J., and Dolan R.J. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 383 (1996) 812-815
23. Morris J.S., Friston K.J., Buchel C., Frith C.D., Young A.W., Calder A.J., and Dolan R.J. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 121 (1998) 47-57
24. Ogawa S., Lee T.M., Kay A.R., and Tank D.W. Brain magnetic resonance imaging with contrast dependent blood oxygenation. Proc Natl Acad Sci USA 87 (1990) 8868-8872
25. Olatunji B.O., Williams N.L., Lohr J.M., and Sawchuk C.N. The structure of disgust: domain specificity in relation to contamination ideation and excessive washing. Behav Res Ther 43 (2005) 1069-1086
26. Parker H.A., McNally R.J., Nakayama K., and Wilhelm S. No disgust recognition deficit in obsessive-compulsive disorder. J Behav Ther Exp Psychiatry 35 (2004) 183-192
27. Phan K.L., Wager T., Taylor S.F., and Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16 (2002) 331-348
28. Phillips M.L., Young A.W., Senior C., Brammer M., Andrew C., Calder A.J., et al. A specific neural substrate for perception of facial expressions of disgust. Nature 389 (1997) 495-498
29. Phillips M.L., Senior C., Fahy T., and David A.S. Disgust-the forgotten emotion of psychiatry. Br J Psychiatry 172 (1998) 373-375
30. Phillips M.L., Young A.W., Scott S.K., Calder A.J., Andrew C., Giampietro V., et al. Neural responses to facial and vocal expressions of fear and disgust. Proc R Soc Lond B 265 (1998) 1809-1817
31. Phillips M.L., Marks I.M., Senior C., Lythgoe D., O'Dwyer A.-M., Meehan O., et al. A differential neural response in obsessive-compulsive patients with washing compared with checking symptoms to disgust. Psychol Medicine 30 (2000) 1037-1050
32. Phillips M.L., Drevets W.C., Rauch S.L., and Lane R. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry 54 (2003) 504-514
33. Phillips M.L., Williams L.M., Young A.W., Russell T., Herba C.M., Heining M., et al. Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage 21 (2004) 1484-1496
34. Saxena S., Brody A.L., Schwartz J.M., and Baxter L.R. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry 173 (1998) 26-38
35. Schienle A., Schafer A., Stark R., Walter B., and Vaitl D. Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. Int J Psychophysiol 57 (2005) 69-77
36. Shapira N.A., Liu Y., He A.G., Bradley M.M., Lessig M.C., James G.A., et al. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry 54 (2003) 751-756
37. Simmons A., Moore E., and Williams S.C.R. Quality control for functional magnetic resonance imaging using automated data analysis and Thwart charting. Magn Reson Med 41 (1999) 1927-1931
38. Spielberger C.D. Manual for the State-Trait Anxiety Inventory (STAI) (1983), Consulting Psychologists Press, Palo Alto
39. Sprengelmeyer R., Rausch M., Eysel U.T., and Przuntek H. Neural structures associated with recognition of facial expressions of basic emotions. Proc Biol Sci 265 (1998) 1927-1931
40. Stein D.J., Liu Y., Shapira N.A., and Goodman W.K. The psychobiology of obsessive-compulsive disorder: how important is the role of disgust?. Curr Psychiatry Rep 3 (2001) 281-287
41. Surguladze S.A., Brammer M.J., Young A.W., Andrew C., Travis M.J., Williams S.C., and Phillips M.L. A preferential increase in the extrastriate response to signals of danger. Neuroimage 19 (2003) 1317-1328
42. Talairach J., and Tournoux P. Co-planar Stereotactic Atlas of the Human Brain (1988), Thieme, Stuttgart, Germany
43. Tolin D.F., Worhunsky P., and Maltby N. Sympathetic magic in contamination-related OCD. J Behav Ther Exp Psychiatry 35 (2004) 193-205
44. Warrington E.K. Short Recognition Memory Test for Faces (1996), Psychology Press, Hove, UK
45. Wood S.R., and Tolin D.F. The relationship between disgust sensitivity and avoidant behavior: studies of clinical and nonclinical samples. J Anxiety Disord 16 (2002) 543-559
46. Young A.W., Rowland D., Calder A.J., Etcoff N.L., Seth A., and Perrett D.I. Facial expression megamix: Tests of dimensional and category accounts of emotion recognition. Cognition 63 (1997) 271-313