The effect of analyte acidity on signal suppression and the implications to peak purity determinations using atmospheric pressure ionization mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 1, 2007, Pages 118-126

  Liao, Kristine ^a   Pack, Brian W ^a   Toltl, Nicholas P ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Co elution; Impurities; LC MS; Peak purity; Signal suppression

Indexed keywords

2,4,6 TRIBROMOPHENOL; 2,4,6 TRICHLOROANILINE; 2,4,6 TRIFLUOROPHENOL; 2,6 DIBROMOPHENOL; 2,6 DICHLOROANILINE; 2,6 DIFLUOROPHENOL; 3,5 DICHLOROANILINE; 4 BROMOANILINE; 4 BROMOPHENOL; 4 CHLOROANILINE; 4 CHLOROPHENOL; 4 FLUOROANILINE; 4 FLUOROPHENOL; 4 IODOANILINE; 4 IODOPHENOL; ANILINE DERIVATIVE; HALOPHENOL; PENTACHLOROPHENOL; PENTAFLUOROPHENOL; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; ATMOSPHERIC PRESSURE; DILUTION; DRUG DETERMINATION; DRUG IMPURITY; DRUG MONITORING; DRUG PURITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; PRIORITY JOURNAL;

ATMOSPHERIC PRESSURE; CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHENOLS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34047248208     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.02.001     Document Type: Article

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