Clinical significance of microvolt T-wave alternans

Herzschrittmachertherapie und Elektrophysiologie

Volumn 18, Issue 1, 2007, Pages 39-44

  Klingenheben, T ^a,b   Ptaszynski, P ^c  

^a Praxis für Kardiologie ^*  (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Arrhythmia risk stratification; Left ventricular function; T wave alternans

Indexed keywords

CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; ELECTRIC POTENTIAL; HEART ARRHYTHMIA; HEART BEAT; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HIGH RISK PATIENT; HUMAN; METHODOLOGY; PATHOPHYSIOLOGY; QT DISPERSION; REVIEW; RISK ASSESSMENT; T WAVE ALTERNANS; VALIDATION PROCESS;

ARRHYTHMIA; CLINICAL TRIALS; ELECTROCARDIOGRAPHY; GERMANY; HUMANS; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 34047231505     PISSN: 09387412     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00399-007-0553-1     Document Type: Review

References (29)

1. Moss AJ, Zareba W, Hall WJ, et al. (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346:877-883
2. Bardy GH, Lee KL, Mark DB, et al. (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225-237
3. Adam DR, Smith JM, Akselrod S, Nyberg S, Powell AO, Cohen RJ (1984) Fluctuations in T wave morphology and susceptibility to ventricular fibrillation. J Electrocardiol 17:209-218
4. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS (1999) Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99:1385-1394
5. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ (1994) Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 330:235-241
6. Schwartz PJ, Malliani A (1975) Electrical alternation of the T wave: clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long-QT syndrome. Am Heart J 89:45-50
7. Adam DR, Akselrod S, Cohen RJ (1981) Estimation of ventricular vulnerability to fibrillation through T wave time series analysis. Comput Cardiol 1981:307-310
8. Shimizu W, Antzelevitch C (1999) Cellular and ionic basis for T-wave alternans under long QT conditions. Cirulation 99:1499-1507
9. Koller ML, Maier SK, Gelzer AR, Bauer WR, Meesmann M, Gilmour RF Jr (2005) Altered dynamics of action potential restitution and alternans in humans with structural heart disease. Circulation 112:1542-1548
10. Selvaraj RJ, Picton P, Nanthakumar K, Mak S, Chauhan VS (2007) Endocardial and epicardial repolarization alternans in human cardiomyopathy: evidence for spatiotemporal heterogeneity and correlation with body surface T-wave alternans. J Am Coll Cardiol 49:338-346
11. Laurita KR, Singal A, Pastore JM, Rosenbaum DS (1998) Spatial heterogeneity of calcium transients may explain action potential dispersion during T-wave alternans (abstr) Circulation 98 (suppl):I-187
12. Rosenbaum DS, Albrecht P, Cohen RJ (1996) Predicting sudden cardiac death from T wave alternans of the surface electrocardiogram: promise and pitfalls. J Cardiovasc Electrophysiol 7:1095-1111
13. Gold MR, Bloomfield DM, Anderson KP, El-Sherif NE, Wilber DJ, Groh WJ, Estes NAM, Kaufman ES, Greenberg ML, Rosenbaum DS (2000) A comparison of T-wave alternans, signal-averaged electrocardiography and programmed ventricular stimulation for arrhythmia risk stratification. J Am Coll Cardiol 36:2247-2253
14. Ikeda T, Sakata T, Takami M, Kondo N, Tezuka N, Nakae T, Noro M, Enjoji Y, Abe R, Sugi K, Yamaguchi T (2000) Combined assessment of Twave alternans and late potentials used to predict arrhythmic events after myocardial infarction. J Am Coll Cardiol 35:722-730
15. Tapanainen JM, Still AM, Airaksinen KEJ, Huikuri HV (2001) Prognostic significance of risk stratifiers of mortality, including T-wave alternans, after acute myocardial infarction: results of a prospective follow-up study. J Cardiovasc Electrophysiol 12:645-652
16. Ikeda T, Saito H, Tanno K, Shimizu H, Watanabe J, Ohnishi Y, Kasamaki Y, Ozawa Y (2002) T-wave alternans as a predictor for sudden cardiac death after myocardial infarction. Am J Cardiol 89:79-82
17. Ikeda T, Yoshino H, Sugi K, Tanno K, Shimizu H, Watanabe J, Kasamaki Y, Yoshida A, Kato T (2006) Predictive value of microvolt T-wave alternans for sudden cardiac death in patients with preserved cardiac function after acute myocardial infarction: results of a collaborative cohort study. J Am Coll Cardiol 48:2268-2274
18. Hohnloser SH, Ikeda T, Bloomfield DM, Dabbous OH, Cohen RJ (2003) T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation. Lancet 362:125-126
19. Klingenheben T, Zabel M, D'Agostino RB, Cohen RJ, Hohnloser SH (2000) Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. Lancet 356:651-652
20. Bloomfield DM, Steinman RC, Namerow PB, Parides M, Davidenko J, Kaufman ES, Shinn T, Curtis A, Fontaine J, Holmes D, Russo A, Tang C, Bigger JT Jr (2004) Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit from implanted cardiac defibrillator therapy: a solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum. Circulation 110:1885-1889
21. Chow T, Kereiakes DJ, Bartone C, Booth T, Schloss EJ, Waller T, Chung ES, Menon S, Nallamothu BK, Chan PS (2006) Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy. J Am Coll Cardiol 47:1820-1827
22. Chan PS, Stein K, Chow T, Fendrick M, Bigger JT, Vijan S (2006) Cost-effectiveness of a microvolt T-wave alternans screening strategy for implantable cardioverter-defibrillator placement in the MADIT-II-eligible population. J Am Coll Cardiol 48: 112-121
23. Chow T, Kereiakes DJ, Bartone C, Booth T, Schloss EJ, Waller T, Chung E, Menon S, Nallamothu BK, Chan PS (2007) Microvolt T-wave alternans identifies patients with ischemic cardiomyopathy who benefit from implantable cardioverter-defibrillator therapy. J Am Coll Cardiol 49:50-58
24. Bloomfield DM, Bigger JT, Steinman RC, Namerow PB, Parides MK, Curtis AB, Kaufman ES, Davidenko JM, Shinn TS, Fontaine JM (2006) Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol 47:456-463
25. Hohnloser SH, Klingenheben T, Bloomfield D, Dabbous O, Cohen RJ (2003) Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study. J Am Coll Cardiol 41:2220-2224
26. Grimm W, Christ M, Bach J, Muller HH, Maisch B (2003) Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy Study. Circulation 108:2883-2891
27. Study to Compare TWA Test and EPS Test for Predicting Patients at Risk for Life-Threatening Heart Rhythms (ABCD). http://clinicaltrials.gov/ct/gui/ show/NCT00187291
28. MASTER I - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients. http://clinicaltrials.gov/ct/show/NCT00305240
29. Russo AM, Marchlinski FE (2007) Should microvolt T-wave alternans be utilized routinely in selecting patients for prophylactic implantable cardioverter-defibrillator insertion in the setting of ischemic heart disease? J Am Coll Cardiol 49:59-61