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Volumn 67, Issue 5, 2007, Pages 793-804

Zoledronic acid: A review of its use in the treatment of Paget's disease of bone

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; AMINOGLYCOSIDE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CLODRONIC ACID; DIURETIC AGENT; ERGOCALCIFEROL; ETIDRONIC ACID; IBANDRONIC ACID; PAMIDRONIC ACID; PLACEBO; RISEDRONIC ACID; TILUDRONIC ACID; ZOLEDRONIC ACID;

EID: 34047203242     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200767050-00011     Document Type: Review
Times cited : (12)

References (43)
  • 1
    • 4243200485 scopus 로고    scopus 로고
    • Management of Paget's disease of bone
    • Langston AL, Ralston SH. Management of Paget's disease of bone. Rheumatology (Oxford) 2004; 43 (8): 955-9
    • (2004) Rheumatology (Oxford) , vol.43 , Issue.8 , pp. 955-959
    • Langston, A.L.1    Ralston, S.H.2
  • 2
    • 33746897394 scopus 로고    scopus 로고
    • Paget's disease of bone
    • Aug 10;
    • Whyte MP. Paget's disease of bone. N Engl J Med 2006 Aug 10; 355 (6): 593-600
    • (2006) N Engl J Med , vol.355 , Issue.6 , pp. 593-600
    • Whyte, M.P.1
  • 3
    • 0032954603 scopus 로고    scopus 로고
    • The epidemiology of Paget's disease in Britain: Is the prevalence decreasing?
    • Cooper C, Schafheutle K, Dennison E, et al. The epidemiology of Paget's disease in Britain: is the prevalence decreasing? J Bone Miner Res 1999; 14 (2): 192-7
    • (1999) J Bone Miner Res , vol.14 , Issue.2 , pp. 192-197
    • Cooper, C.1    Schafheutle, K.2    Dennison, E.3
  • 4
    • 0017616770 scopus 로고
    • Paget's diease of bone in 14 British towns
    • May 7;
    • Barker DJP, Clough PWL, Guyer PB, et al. Paget's diease of bone in 14 British towns. Br Med J 1977 May 7; 1: 1181-3
    • (1977) Br Med J , vol.1 , pp. 1181-1183
    • Barker, D.J.P.1    Clough, P.W.L.2    Guyer, P.B.3
  • 5
    • 0036755909 scopus 로고    scopus 로고
    • Guidelines on the management of Paget's disease of bone
    • Sep;
    • Selby PL, Davie MWJ, Ralston SH, et al. Guidelines on the management of Paget's disease of bone. Bone 2002 Sep; 31 (3): 366-73
    • (2002) Bone , vol.31 , Issue.3 , pp. 366-373
    • Selby, P.L.1    Davie, M.W.J.2    Ralston, S.H.3
  • 6
    • 24044444602 scopus 로고    scopus 로고
    • Treatment of Paget's disease: Taming the wild osteoclast
    • Sep 1;
    • Deftos LJ. Treatment of Paget's disease: taming the wild osteoclast. N Engl J Med 2005 Sep 1; 353 (9): 872-5
    • (2005) N Engl J Med , vol.353 , Issue.9 , pp. 872-875
    • Deftos, L.J.1
  • 7
    • 0035015480 scopus 로고    scopus 로고
    • Drake WM, Kendler DL, Brown JP. Consensus statement on the modern therapy of Paget's disease of bone from a Western Osteoporosis Alliance symposium. Clin Ther 2001 Apr; 23 (4): 620-6
    • Drake WM, Kendler DL, Brown JP. Consensus statement on the modern therapy of Paget's disease of bone from a Western Osteoporosis Alliance symposium. Clin Ther 2001 Apr; 23 (4): 620-6
  • 8
    • 9044220965 scopus 로고    scopus 로고
    • Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone
    • Siris E, Weinstein RS, Altman R, et al. Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone. J Clin Endocrinol Metab 1996; 81 (3): 961-7
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.3 , pp. 961-967
    • Siris, E.1    Weinstein, R.S.2    Altman, R.3
  • 9
    • 0033135850 scopus 로고    scopus 로고
    • A randomized, double-blind comparison of risedronate and etidronate in the treatment of Paget's disease of bone
    • May;
    • Miller PD, Brown JP, Siris ES, et al. A randomized, double-blind comparison of risedronate and etidronate in the treatment of Paget's disease of bone. Am J Med 1999 May; 106 (5): 513-20
    • (1999) Am J Med , vol.106 , Issue.5 , pp. 513-520
    • Miller, P.D.1    Brown, J.P.2    Siris, E.S.3
  • 10
    • 0029055541 scopus 로고
    • Comparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone
    • Jun;
    • Roux C, Gennari C, Farrerons J, et al. Comparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone. Arthritis Rheum 1995 Jun; 38 (6): 851-8
    • (1995) Arthritis Rheum , vol.38 , Issue.6 , pp. 851-858
    • Roux, C.1    Gennari, C.2    Farrerons, J.3
  • 11
    • 33846219426 scopus 로고    scopus 로고
    • Clinical determinants of quality of life in Paget's disease of bone
    • Langston AL, Campbell MK, Fraser WD, et al. Clinical determinants of quality of life in Paget's disease of bone. Calcif Tissue Int 2007; 80: 1-9
    • (2007) Calcif Tissue Int , vol.80 , pp. 1-9
    • Langston, A.L.1    Campbell, M.K.2    Fraser, W.D.3
  • 12
    • 33744762777 scopus 로고    scopus 로고
    • Bisphosphonates: From bench to bedside
    • Apr;
    • Russell RGG. Bisphosphonates: from bench to bedside. Ann N Y Acad Sci 2006 Apr; 1068: 367-401
    • (2006) Ann N Y Acad Sci , vol.1068 , pp. 367-401
    • Russell, R.G.G.1
  • 13
    • 0035146537 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
    • Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 2001; 296 (2): 235-42
    • (2001) J Pharmacol Exp Ther , vol.296 , Issue.2 , pp. 235-242
    • Dunford, J.E.1    Thompson, K.2    Coxon, F.P.3
  • 14
    • 33646725498 scopus 로고    scopus 로고
    • The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
    • May 16;
    • Kavanagh KL, Guo K, Dunford JE, et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci USA 2006 May 16; 103 (20): 7829-34
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.20 , pp. 7829-7834
    • Kavanagh, K.L.1    Guo, K.2    Dunford, J.E.3
  • 15
    • 33646089442 scopus 로고    scopus 로고
    • Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite
    • May;
    • Nancollas GH, Tang R, Phipps RJ, et al. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone 2006 May; 38 (5): 617-27
    • (2006) Bone , vol.38 , Issue.5 , pp. 617-627
    • Nancollas, G.H.1    Tang, R.2    Phipps, R.J.3
  • 16
    • 29744457710 scopus 로고    scopus 로고
    • In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts
    • Dec;
    • Kellinsalmi M, Mönkkönen H, Mönkkönen J, et al. In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts. Basic Clin Pharmacol Toxicol 2005 Dec; 97 (6): 382-91
    • (2005) Basic Clin Pharmacol Toxicol , vol.97 , Issue.6 , pp. 382-391
    • Kellinsalmi, M.1    Mönkkönen, H.2    Mönkkönen, J.3
  • 17
    • 0036062211 scopus 로고    scopus 로고
    • Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption
    • Green JR, Rogers MJ. Pharmacologic profile of zoledronic acid: a highly potent inhibitor of bone resorption. Drug Dev Res 2002; 55: 210-24
    • (2002) Drug Dev Res , vol.55 , pp. 210-224
    • Green, J.R.1    Rogers, M.J.2
  • 18
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42′446, a new, potent, heterocyclic bisphosphonate compound
    • Green JR, Müller K, Jaeggi KA. Preclinical pharmacology of CGP 42′446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 1994; 9 (5): 745-51
    • (1994) J Bone Miner Res , vol.9 , Issue.5 , pp. 745-751
    • Green, J.R.1    Müller, K.2    Jaeggi, K.A.3
  • 19
    • 18844467280 scopus 로고    scopus 로고
    • Single infusion of zoledronate in Paget's disease of bone: A placebo-controlled, dose-ranging study
    • May;
    • Buckler H, Fraser W, Hosking D, et al. Single infusion of zoledronate in Paget's disease of bone: a placebo-controlled, dose-ranging study. Bone 1999 May; 24 (5 Suppl.): 81-5S
    • (1999) Bone , vol.24 , Issue.5 SUPPL.
    • Buckler, H.1    Fraser, W.2    Hosking, D.3
  • 20
    • 18644373689 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases
    • Nov;
    • Chen T, Berenson J, Vescio R, et al. Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases. J Clin Pharmacol 2002 Nov; 42 (11): 1228-36
    • (2002) J Clin Pharmacol , vol.42 , Issue.11 , pp. 1228-1236
    • Chen, T.1    Berenson, J.2    Vescio, R.3
  • 21
    • 0347708657 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with varying degrees of renal function
    • Feb;
    • Skerjanec A, Berenson J, Hsu C, et al. The pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with varying degrees of renal function. J Clin Pharmacol 2003 Feb; 43 (2): 154-62
    • (2003) J Clin Pharmacol , vol.43 , Issue.2 , pp. 154-162
    • Skerjanec, A.1    Berenson, J.2    Hsu, C.3
  • 22
    • 33646657852 scopus 로고    scopus 로고
    • A population pharmacokinetic model for zoledronic acid (Zometa) in patients with bone metastases [abstract no. PIII-20]
    • Feb;
    • Booth BP, Rahman A, Ibrahim A, et al. A population pharmacokinetic model for zoledronic acid (Zometa) in patients with bone metastases [abstract no. PIII-20]. Clin Pharmacol Ther 2003 Feb; 73 (2): 67
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.2 , pp. 67
    • Booth, B.P.1    Rahman, A.2    Ibrahim, A.3
  • 23
    • 0003443998 scopus 로고    scopus 로고
    • European Medicines Agency, online, Available from URL:, Accessed Dec 11
    • European Medicines Agency. Summary of product characteristics: zoledronic acid [online]. Available from URL: http://emea.eu.int [Accessed 2006 Dec 11]
    • (2006) Summary of product characteristics: Zoledronic acid
  • 24
    • 0030896159 scopus 로고    scopus 로고
    • Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone
    • May;
    • Arden-Cordone M, Siris ES, Lyles KW, et al. Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone. Calcif Tissue Int 1997 May; 60 (5): 415-8
    • (1997) Calcif Tissue Int , vol.60 , Issue.5 , pp. 415-418
    • Arden-Cordone, M.1    Siris, E.S.2    Lyles, K.W.3
  • 25
    • 24044431619 scopus 로고    scopus 로고
    • Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease
    • Sep 1;
    • Reid IR, Miller P, Lyles K, et al. Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease. N Engl J Med 2005 Sep 1; 353 (9): 898-908
    • (2005) N Engl J Med , vol.353 , Issue.9 , pp. 898-908
    • Reid, I.R.1    Miller, P.2    Lyles, K.3
  • 26
    • 33845933979 scopus 로고    scopus 로고
    • Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate
    • Hosking D, Lyles K, Brown JP, et al. Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate. J Bone Miner Res 2007; 22 (1): 142-8
    • (2007) J Bone Miner Res , vol.22 , Issue.1 , pp. 142-148
    • Hosking, D.1    Lyles, K.2    Brown, J.P.3
  • 27
    • 34047230883 scopus 로고    scopus 로고
    • Kurth AA, Kotowa W, Fricke FU, et al. Zoledronic acid in the long-term management of Paget's disease of the bone in Germany - a cost-saving approach? [abstract no. PAR2]. Value Health 2006 Nov-Dec; 9 (6): A220. Plus poster presented at the 9th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2006 Oct 29-31; Copenhagen
    • Kurth AA, Kotowa W, Fricke FU, et al. Zoledronic acid in the long-term management of Paget's disease of the bone in Germany - a cost-saving approach? [abstract no. PAR2]. Value Health 2006 Nov-Dec; 9 (6): A220. Plus poster presented at the 9th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2006 Oct 29-31; Copenhagen
  • 28
    • 34047240464 scopus 로고    scopus 로고
    • Lecomte P, Devogelaer JP, Kaufman JM, et al. Cost-effectiveness analysis of Aclasta in Paget's disease of bone in Belgium [abstract no. PMD2]. Value Health 2005 Nov-Dec; 8 (6): A73-4. Plus poster presented at the 8th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2005 Nov 6-8; Florence
    • Lecomte P, Devogelaer JP, Kaufman JM, et al. Cost-effectiveness analysis of Aclasta in Paget's disease of bone in Belgium [abstract no. PMD2]. Value Health 2005 Nov-Dec; 8 (6): A73-4. Plus poster presented at the 8th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research; 2005 Nov 6-8; Florence
  • 29
    • 34047234560 scopus 로고    scopus 로고
    • Medical management of Paget's disease of bone: Indications for treatment and review of current therapies
    • Dec;
    • Siris ES, Lyles KW, Singer FR, et al. Medical management of Paget's disease of bone: indications for treatment and review of current therapies. J Bone Miner Res 2006 Dec; 21 Suppl. 2: P94-8
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 2
    • Siris, E.S.1    Lyles, K.W.2    Singer, F.R.3
  • 30
    • 0037669820 scopus 로고    scopus 로고
    • Modern therapy for Paget's disease of bone: Focus on bisphosphonates
    • Devogelaer J-P. Modern therapy for Paget's disease of bone: focus on bisphosphonates. Treat Endocrinol 2002; 1 (4): 241-57
    • (2002) Treat Endocrinol , vol.1 , Issue.4 , pp. 241-257
    • Devogelaer, J.-P.1
  • 31
    • 0034927419 scopus 로고    scopus 로고
    • A clinical approach to diagnosis and management of Paget's disease of bone
    • Lyles KW, Siris ES, Singer FR, et al. A clinical approach to diagnosis and management of Paget's disease of bone. J Bone Miner Res 2001; 16 (8): 1379-87
    • (2001) J Bone Miner Res , vol.16 , Issue.8 , pp. 1379-1387
    • Lyles, K.W.1    Siris, E.S.2    Singer, F.R.3
  • 32
    • 10544223736 scopus 로고    scopus 로고
    • Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: A randomized, placebo-controlled trial
    • Oct;
    • Reid IR, Nicholson GC, Weinstein RS, et al. Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: a randomized, placebo-controlled trial. Am J Med 1996 Oct; 101 (4): 341-8
    • (1996) Am J Med , vol.101 , Issue.4 , pp. 341-348
    • Reid, I.R.1    Nicholson, G.C.2    Weinstein, R.S.3
  • 33
    • 0026740665 scopus 로고
    • Evaluation of the efficacy and safety of oral tiludronate in Paget's disease of bone: A double-blind, multiple-dosage, placebo-controlled study
    • Aug;
    • Reginster JY, Colson F, Morlock G, et al. Evaluation of the efficacy and safety of oral tiludronate in Paget's disease of bone: a double-blind, multiple-dosage, placebo-controlled study. Arthritis Rheum 1992 Aug; 35 (8): 967-74
    • (1992) Arthritis Rheum , vol.35 , Issue.8 , pp. 967-974
    • Reginster, J.Y.1    Colson, F.2    Morlock, G.3
  • 34
    • 0030826122 scopus 로고    scopus 로고
    • A double-blind, multicentre, placebo-controlled study of tiludronate in Paget's disease of bone
    • Aug;
    • Fraser WD, Stamp TC, Creek RA, et al. A double-blind, multicentre, placebo-controlled study of tiludronate in Paget's disease of bone. Postgrad Med J 1997 Aug; 73 (862): 496-502
    • (1997) Postgrad Med J , vol.73 , Issue.862 , pp. 496-502
    • Fraser, W.D.1    Stamp, T.C.2    Creek, R.A.3
  • 35
    • 12144290114 scopus 로고    scopus 로고
    • A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget's disease of bone
    • Apr 1;
    • Walsh JP, Ward LC, Stewart GO, et al. A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget's disease of bone. Bone 2004 Apr 1; 34: 747-54
    • (2004) Bone , vol.34 , pp. 747-754
    • Walsh, J.P.1    Ward, L.C.2    Stewart, G.O.3
  • 36
    • 34047233227 scopus 로고    scopus 로고
    • Paget's disease and bisphosphonates [letter]
    • Dec 15;
    • Reid IR, Miller P, Hosking D. Paget's disease and bisphosphonates [letter]. N Engl J Med 2005 Dec 15; 353 (24): 2617-8
    • (2005) N Engl J Med , vol.353 , Issue.24 , pp. 2617-2618
    • Reid, I.R.1    Miller, P.2    Hosking, D.3
  • 37
    • 31744441494 scopus 로고    scopus 로고
    • Pharmacological therapy of Paget's and other metabolic bone diseases
    • Feb;
    • Hosking D. Pharmacological therapy of Paget's and other metabolic bone diseases. Bone 2006 Feb; 38 (2 Suppl. 2): S3-7
    • (2006) Bone , vol.38 , Issue.2 SUPPL. 2
    • Hosking, D.1
  • 38
    • 0037287351 scopus 로고    scopus 로고
    • Zoledronic acid: A review of its use in the management of bone metastases and hypercalcaemia of malignancy
    • Wellington K, Goa KL. Zoledronic acid: a review of its use in the management of bone metastases and hypercalcaemia of malignancy. Drugs 2003; 63 (4): 417-37
    • (2003) Drugs , vol.63 , Issue.4 , pp. 417-437
    • Wellington, K.1    Goa, K.L.2
  • 39
    • 33646836925 scopus 로고    scopus 로고
    • Systematic review: Bisphosphonates and osteonecrosis of the jaw
    • May 16;
    • Woo S-B, Hellstein JW, Kalmar JR. Systematic review: bisphosphonates and osteonecrosis of the jaw. Ann Intern Med 2006 May 16; 144 (10): 753-61
    • (2006) Ann Intern Med , vol.144 , Issue.10 , pp. 753-761
    • Woo, S.-B.1    Hellstein, J.W.2    Kalmar, J.R.3
  • 40
    • 33845350899 scopus 로고    scopus 로고
    • Bone necrosis of the jaws associated with bisphosphonate treatment: A report of twenty-nine cases
    • Aug;
    • Merigo E, Manfredi M, Meleti M, et al. Bone necrosis of the jaws associated with bisphosphonate treatment: a report of twenty-nine cases. Acta Biomed 2006 Aug; 77 (2): 109-17
    • (2006) Acta Biomed , vol.77 , Issue.2 , pp. 109-117
    • Merigo, E.1    Manfredi, M.2    Meleti, M.3
  • 41
    • 33751528987 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw: Do bisphosphonates pose a risk?
    • Nov 30;
    • Bilezikian JP. Osteonecrosis of the jaw: do bisphosphonates pose a risk? N Engl J Med 2006 Nov 30; 355 (22): 2278-81
    • (2006) N Engl J Med , vol.355 , Issue.22 , pp. 2278-2281
    • Bilezikian, J.P.1
  • 42
    • 17644406724 scopus 로고    scopus 로고
    • Bisphosphonates and avascular necrosis of the jaw: A possible association
    • Apr 18;
    • Carter G, Goss AN, Doecke C. Bisphosphonates and avascular necrosis of the jaw: a possible association. Med J Aus 2005 Apr 18; 182 (8): 413-5
    • (2005) Med J Aus , vol.182 , Issue.8 , pp. 413-415
    • Carter, G.1    Goss, A.N.2    Doecke, C.3
  • 43
    • 34047209975 scopus 로고    scopus 로고
    • European Medicines Agency, discussion: zoledronic acid [online, Available from URL:, Accessed Jan 3
    • European Medicines Agency. Scientific discussion: zoledronic acid [online]. Available from URL: http://emea.eu.int [Accessed 2007 Jan 3]
    • (2007) Scientific


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