Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-propyl bromide)

Clinical Toxicology

Volumn 45, Issue 3, 2007, Pages 270-276

  Majersik, Jennifer Juhl ^a,d   Caravati, E Martin ^b   Steffens, John D ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Utah Poison Control   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

1 Bromopropane; N propyl bromide; Neurotoxicity; Solvent; Spastic paraparesis

Indexed keywords

1 BROMOPROPANE (N PROPYLBROMIDE); SOLVENT; UNCLASSIFIED DRUG;

ADULT; AIR SAMPLING; ANAMNESIS; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; ELECTROMYOGRAM; FEMALE; HEADACHE; HUMAN; HYPERREFLEXIA; LABORATORY TEST; LEG PAIN; MALE; NAUSEA; NEUROLOGIC EXAMINATION; NEUROPATHIC PAIN; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCUPATIONAL EXPOSURE; PARESTHESIA; SENSORY DYSFUNCTION; SPASTIC PARAPLEGIA; VAPOR; WORKPLACE;

ADOLESCENT; ADULT; AIR POLLUTANTS, OCCUPATIONAL; FEMALE; HUMANS; HYDROCARBONS, BROMINATED; INHALATION EXPOSURE; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PARAPARESIS, SPASTIC; PERIPHERAL NERVOUS SYSTEM DISEASES; SOLVENTS;

EID: 34047167534     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701226218     Document Type: Article

References (23)

1. Yu X, Ichihara G, Kitoh J, Xie Z, Shibata E, Kamijima M, Asaeda N, Takeuchi Y. Preliminary report on the neurotoxicity of 1-bromopropane, an alternative solvent for chlorofluorocarbons. J Occup Health 1998; 40:234-235.
2. Ichihara G, Kitoh J, Yu X, Asaeda N, Iwai H, Kumazawa T, Shibata E, Yamada T, Wang H, Xie Z, Takeuchi Y. 1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure. Toxicol Sci 2000; 55:116-123.
3. Wang H, Ichihara G, Ito H, Kato K, Kitoh J, Yamada T, Yu X, Tsuboi S, Moriyama Y, Sakatani R, Shibata E, Kamijima M, Itohara S, Takeuchi Y. Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days. Toxicol Sci 2002; 67:114-120.
4. Yu X, Ichihara G, Kitoh J, Xie Z, Shibata E, Kamijima M, Takeuchi Y. Neurotoxicity of 2-bromopropane and 1-bromopropane, alternative solvents for chlorofluorocarbons. Environ Res 2001; 85:48-52.
5. Ichihara G, Miller J, Ziolkokwska A, Itohara S, Takeuchi Y. Neurological disorders in three workers exposed to 1-bromopropane. J Occup Health 2002; 44:1-7.
6. Sclar G. Encephalomyeloradiculoneuropathy following exposure to an industrial solvent. Clin Neurol Neurosurg 1999; 101:199-202.
7. Marx Industries Inc. Utah Labor Commission, Occupational Safety and Health Division, 2003. Report No. 305400616.
8. Sohn YK, Suh JS, Kim JW, Seo HH, Kim JY, Kim HY, Lee JY, Lee SB, Han JH, Lee YM, Lee JY. A histopathologic study of the nervous system after inhalation exposure of 1-bromopropane in rat. Toxicol Lett 2002; 131:195-201.
9. Harney J, Nemhauser J, Reh C, Trout D, Schrader S. Health hazard evaluation report: Marx Industries, Inc., Sawmills, North Carolina. Centers for Disease Control and Prevention. National Institute for Occupational Safety and Health, June 2003. Report No. HETA 99-0260-2906.
10. Harney J, Hess J, Reh C, Trout D. Health Hazard Evaluation Report, STN Cushion Company, Thomasville, North Carolina. Centers for Disease Control and Prevention. National Institute for Occupational Safety and Health, August 2002. Report No. HETA 2000-0410-2891.
11. Ichihara G, Li W, Ding X, Peng S, Yu X, Shibata E, Yamada T, Wang H, Itohara S, Kanno S, Sakai K, Ito H, Kanefusa K, Takeuchi Y. A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane. Am J Ind Med 2004; 45:63-75.
12. Ichihara G, Li W, Shibata E, Ding X, Wang H, Liang Y, Peng S, Itohara S, Kamijima M, Fan Q, Zhang Y, Zhong E, Wu X, Valentine WM, Takeuchi Y. Neurologic abnormalities in workers of a 1-bromopropane factory. Environ Health Perspect 2004; 112:1319-1325.
13. Thomas PK, Schaumburg HH, Spencer PS, Kaeser HE, Pallis CA, Rose FC, Wadia NH. Central distal axonopathy syndromes: newly recognized models of naturally occurring human degenerative disease. Ann Neurol 1984; 15:313-315.
14. Ishidao T, Kunugita N, Fueta Y, Arashidani K, Hori H. Effects of inhaled 1-bromopropane vapor on rat metabolism. Toxicol Lett 2002; 134:237-243.
15. Kawai T, Takeuchi Y, Miyama Y, Sakamto K, Zhang Z, Higashikawa M. Biological monitoring of occupational exposure to 1-bromopropane by means of urinalysis for 1-bromopropane and bromide ion. Biomarkers 2001; 6:303-312.
16. Hanley KW, Petersen M, Curwin BD, Sanderson WT. Urinary bromide and breathing zone concentrations of 1-bromopropane from workers exposed to flexible foam spray adhesives. Ann Occup Hyg. 2006 Aug; 50(6):599-607. E-pub 2006 May 12.
17. Frances C, Hoizey G, Lamiable D, Millart H, Trenque T. Bromism from daily over intake of bromide salt. J Toxicol Clin Toxicol 2003; 41:181-183.
18. Horowitz BZ. Bromism from excessive cola consumption. J Toxicol Clin Toxicol 1997; 35:315-320.
19. Yamano Y, Nakadate T. Three occupationally exposed cases of severe methyl bromide poisoning: accident caused by a gas leak during the fumigation of a folklore museum. J Occup Health 2006; 48:129-133.
20. De Haro L, Gastaut JL, Jouglard J, Renacco E. Central and peripheral neurotoxic effects of chronic methyl bromide intoxication. J Toxicol Clin Toxicol 1997; 35:29-34.
21. Lifshitz M, Gavrilov V. Central nervous system toxicity and early peripheral neuropathy following dermal exposure to methyl bromide. J Toxicol Clin Toxicol 2000; 38:799-801.
22. United States Environmental Protection Agency . Protection of stratospheric ozone: listing of substitutes for ozone-depleting substances - n-propyl bromide, June 3, 2003. Report No. 40 CFR Part 82.
23. Rozman KK, Doull J. Derivation of an occupational exposure limit (OEL) for n-propyl bromide using an improved methodology. Appl Occup Environ Hyg 2002; 17:711-716.