Myelin Vacuolation, Optic Neuropathy and Retinal Degeneration after Closantel Overdosage in Sheep and in a Goat

Journal of Comparative Pathology

Volumn 136, Issue 2-3, 2007, Pages 87-95

  van der Lugt, J J ^a   Venter, I ^b  

^a Departments of Paraclinical Sciences   (Netherlands)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

closantel; goat; halogenated salicylanilides; myelin oedema; optic neuropathy; retinal degeneration; sheep; status spongiosis

Indexed keywords

ANTHELMINTIC AGENT; CLOSANTEL; SALICYLANILIDE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SPONGIOSIS; CELL VACUOLE; DISEASE SEVERITY; DRUG OVERDOSE; GOAT DISEASE; HISTOPATHOLOGY; MYELIN SHEATH; NERVE DEGENERATION; NONHUMAN; OPHTHALMOSCOPY; OPTIC NERVE ATROPHY; OPTIC NERVE DISEASE; OPTIC NERVE LESION; PAPILLEDEMA; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA DETACHMENT; SHEEP DISEASE; WHITE MATTER;

ANIMALS; ANTHELMINTICS; CEREBELLUM; GOAT DISEASES; GOATS; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; OPTIC NERVE DISEASES; OVERDOSE; RETINAL DEGENERATION; SALICYLANILIDES; SHEEP; SHEEP DISEASES; TELENCEPHALON; VACUOLES;

CAPRA HIRCUS; OVIS ARIES; WALLERIA;

EID: 34047161491     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2006.11.007     Document Type: Article

References (41)

1. Adornato B., and Lampert P. Status spongiosis of nervous tissue. Acta Neuropathologica (Berl.) 19 (1971) 271-289
2. Bacon J.A., Ulrich R.G., Davis J.P., Thomas E.M., Johnson S.S., Condor G.A., Sangster N.C., Rothwell J.T., McCracken R.O., Lee B.H., Clothier M.F., Geary T.G., and Thompson D.P. Comparative in vitro effects of closantel and selected β-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. Journal of Veterinary Pharmacology and Therapeutics 21 (1998) 190-196
3. Barlow A.M., Sharpe J.A.E., and Kincaid E.A. Blindness in lambs due to inadvertent closantel overdose. Veterinary Record 151 (2002) 25-26
4. Borges A.S., Mendes L.C.N., De Andrade A.L., Machado G.F., and Peiro J.R. Optic neuropathy in sheep associated with overdosage of closantel. Veterinary and Human Toxicology 41 (1999) 378-380
5. Button C., Jerrett I., Alexander P., and Mizon W. Blindness in kids associated with overdose of closantel. Australian Veterinary Journal 64 (1987) 226
6. Cho D.Y., and Leipold H.W. Experimental spongy degeneration in calves. Acta Neuropathologica (Berl.) 39 (1977) 115-127
7. Dodd P.R., Williams S.H., Gundlach A.L., Harper P.A.W., Healy P.J., Dennis J.A., and Johnston A.R. Glutamate and γ-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves. Journal of Neurochemistry 59 (1992) 582-590
8. Gill P.A., Cook R.W., Boulton J.G., Kelly W.R., Vanselow B., and Reddacliff L.A. Optic neuropathy and retinopathy in closantel toxicosis of sheep and goats. Australian Veterinary Journal 77 (1999) 259-261
9. Harper P.A.W., Dennis J.A., Healy P.J., and Brown G.K. Maple syrup urine disease in calves: a clinical, pathological and biochemical study. Australian Veterinary Journal 66 (1989) 46-49
10. Harper P.A.W., Healy P.J., and Dennis J.A. Ultrastructural findings in maple syrup urine disease in poll Hereford calves. Acta Neuropathologica (Berl.) 71 (1986) 316-320
11. Huxtable, C.R., Dorling, P.R. and Colegate, S.M. (1992). Stypandra poisoning: the role of stypandrol and proposed pathomechanisms. In: Poisonous Plants: Proceedings of the Third International Symposium, L.F. James, R.F. Keeler, E.M. Bailey, P.R. Cheeke and M.P. Hegarty, Eds, Iowa State University Press, Ames, pp. 464-468.
12. Huxtable C.R., Dorling P.R., and Slatter D.H. Myelin oedema, optic neuropathy and retinopathy in experimental Stypandra toxicosis. Neuropathology and Applied Neurobiology 6 (1980) 221-232
13. Jacobs J.M., Crertier J.E., and Cavanagh J.B. Acute effects of triethyl tin on the rat myelin sheath. Neuropathology and Applied Neurobiology 3 (1977) 169-181
14. Kellerman T.S., Prozesky L., Schultz R.A., Rabie C.J., Van Ark H., Maartens B.P., and Lübben A. Perinatal mortality in lambs of ewes exposed to cultures of Diplodia maydis (= Stenocarpella maydis) during gestation. Onderstepoort Journal of Veterinary Research 58 (1991) 297-308
15. Kellerman T.S., Rabie C.J., Van der Westhuizen G.C.A., Kriek N.P.J., and Prozesky L. Induction of diplodiosis, a neuromycotoxicosis, in domestic ruminants with cultures of indigenous and exotic isolates of Diplodia maydis. Onderstepoort Journal of Veterinary Research 52 (1985) 35-42
16. Kreutzberg, G.W., Blakemore, W.F. and Graeber, M.B. (1997). Cellular pathology of the central nervous system. In: Greenfield's Neuropathology, 2nd Edit., D.I. Graham and P.L. Lantos, Eds, Arnold, London, pp. 85-140.
17. Lampert P., O'Brien J., and Garrett R. Hexachlorophene encephalopathy. Acta Neuropathologica (Berl.) 23 (1973) 326-333
18. Lampert P.W., and Schochet S.S. Electron microscopic observations on experimental spongy degeneration of the cerebellar white matter. Journal of Neuropathology and Experimental Neurology 27 (1986) 210-220
19. Main D.C., Slatter D.H., Huxtable C.R., Constable I.C., and Dorling P.R. Stypandra imbricata ("blindgrass") toxicosis in goats and sheep-clinical and pathological findings in 4 field cases. Australian Veterinary Journal 57 (1981) 132-135
20. McEntee K., Grauwels M., Clercx C., and Henroteaux M. Closantel intoxication in a dog. Veterinary and Human Toxicology 37 (1995) 234-236
21. Morgan K.T. Chronic copper toxicity of sheep: an ultrastructural study of spongiform leucoencephalopathy. Research in Veterinary Science 15 (1973) 88-95
22. Morgan K.T., Gross E.A., Lyght O., and Bond J.A. Morphologic and biochemical studies of a nitrobenzene-induced encephalopathy in rats. Neurotoxicology 6 (1985) 105-116
23. Obwolo M.J., Odiawo G.O., and Ogaa J.S. Toxicity of a closantel-albendazole mixture in a flock of sheep and goats. Australian Veterinary Journal 66 (1989) 229-230
24. Odiawo G.O., Ogaa J.S., Ndikuwera J., and Moulton J.E. Acute amaurosis in sheep due to rafoxanide neurotoxicity. Zimbabwe Veterinary Journal 22 (1991) 64-69
25. Okazaki Y., Yamashita K., Sudo M., Tsuchitani M., Narama I., Yamaguchi R., and Tateyama S. Neurotoxicity induced by a single oral dose of aniline in rats. Journal of Veterinary Medical Science 63 (2001) 539-546
26. Prozesky L., Kellerman T.S., Swart D.P., Maartens B.P., and Schultz R.A. Perinatal mortality in lambs exposed to cultures of Diplodia maydis (= Stenocarpella maydis) during gestation. A study of the central nervous system lesions. Onderstepoort Journal of Veterinary Research 61 (1994) 247-253
27. Prozesky L., and Pienaar J.G. Amaurosis in sheep resulting from treatment with rafoxanide. Onderstepoort Journal of Veterinary Research 44 (1977) 257-260
28. Scagliotti, R.H. (1999). Comparative neuro-ophthalmology. In: Veterinary Ophthalmology, 3rd Edit., K.N. Gelatt, Ed., Lippincott Williams & Wilkins, Philadelphia, pp. 1307-1400.
29. Seawright, A.A. (1989). Animal Health in Australia, Vol. 2, Chemical and Plant Poisonings, 2nd Edit., Australian Government Publishing Service, Canberra, pp. 331-332.
30. Sims, M.H. (1999). Electrodiagnostic evaluation of vision. In: Veterinary Ophthalmology, 3rd Edit., K.N. Gelatt, Ed., Lippincott Williams & Wilkins, Philadelphia, pp. 483-507.
31. Spencer, W.H. (1986). Optic nerve. In: Ophthalmic Pathology: an Atlas and Textbook, 3rd Edit., W.H. Spencer, Ed., W.B. Saunders, Philadelphia, pp. 2337-2458.
32. Summers, B.A., Cummings, J.F. and De Lahunta, A. (1995). Veterinary Neuropathology, Mosby, St Louis, pp. 1-67, 214-236.
33. Suzuki K., and Kikkana Y. Status spongiosis of CNS and hepatic damage induced by cuprizone (biscyclohexanone oxalyldihydrazone). American Journal of Pathology 54 (1969) 307-325
34. Swan G.E. The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. Journal of the South African Veterinary Association 70 (1999) 61-70
35. Towfighi, J. (1980). Hexachlorophene. In: Experimental and Clinical Neurotoxicology, P.S. Spencer and H.H. Schaumburg, Eds, Williams & Wilkins, Baltimore and London, pp. 440-455.
36. van der Lugt J.J., Olivier J., and Jordaan P. Status spongiosis, optic neuropathy, and retinal degeneration in Helichrysum argyrosphaerum poisoning in sheep and a goat. Veterinary Pathology 33 (1996) 495-502
37. Verity, M.A. (1997). Toxic disorders. In: Greenfield's Neuropathology, 6th Edit., D.I. Graham and P.L. Lantos, Eds, Arnold, London, pp. 755-811.
38. Watanae, I. (1980). Organotins (triethyltin). In: Experimental and Clinical Neurotoxicology, P.S. Spencer and H.H. Schaumburg, Eds, Williams & Wilkins, Baltimore and London, pp. 545-557.
39. Watson W.A., Barnett K.C., and Terlicki S. Progressive retinal degeneration (bright blindness) in sheep: a review. Veterinary Record 91 (1972) 665-670
40. Watson W.A., Terlicki S., Patterson D.S.P., Herbert C.N., and Done J.T. Experimentally produced progressive retinal degeneration (bright blindness) in sheep. British Veterinary Journal 128 (1972) 457-469
41. Whittington R.J., Searson J.E., Whittaker S.J., and Glastonbury J.R.W. Blindness in goats following ingestion of Stypandra glauca. Australian Veterinary Journal 65 (1988) 176-181