Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding

Science

Volumn 315, Issue 5819, 2007, Pages 1729-1732

  Melčák, Ivo ^a   Hoelz, André ^a   Blobel, Günter ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPORIN; PROTEIN NUP45; PROTEIN NUP58; TETRAMER; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; HYDROPHOBICITY; PROTEIN;

ALPHA HELIX; ARTICLE; CRYSTAL STRUCTURE; HYDROPHOBICITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RAT; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; STATIC ELECTRICITY;

MAMMALIA;

EID: 34047159864     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135730     Document Type: Article

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29. We thank Š. Melčáková, M. Müller, and T. Schwartz for help at the initial stages of the project; L. Gerace for the gift of cDNAs; B. Manjasetty (National Synchrotron Light Source) and C. Ralston (Advanced Light Source) for their excellent scientific support and help with x-ray measurements; T. Huber for stimulating discussions; E. Coutavas, M. King, A. Patke, and S. Solmaz for critical reading of the manuscript and S. Etherton for help with editing of the manuscript. A.H. was supported by a grant from the Leukemia and Lymphoma Society. G.B. is an investigator of the Howard Hughes Medical Institute. The coordinates and structure factors have been deposited in the Protein Data Bank (accession code 2OSZ).