The role of flexible polymer interconnects in chronic tissue response induced by intracortical microelectrodes - A modeling and an in vivo study

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn , Issue , 2006, Pages 3588-3591

  Subbaroyan, Jeyakumar ^b   Kipke, Daryl R ^a,b  

^a IEEE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC TISSUE RESPONSE; FLEXIBLE INTERCONNECTS; GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP); IMMUNOHISTOCHEMISTRY;

COMPUTER SIMULATION; FINITE ELEMENT METHOD; MICROELECTRODES; POLYMERS; PROTEIN FOLDING; STRAIN; TISSUE;

IMPLANTS (SURGICAL);

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL COMMUNICATION; CELL COUNT; ELECTRODE IMPLANT; ELECTROSTIMULATION; HUMAN; METABOLISM; METHODOLOGY; MICROELECTRODE; NERVE CELL; PHYSIOLOGY;

ANIMALS; CELL COMMUNICATION; CELL COUNT; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MICROELECTRODES; MODELS, NEUROLOGICAL; NEURONS;

EID: 34047150512     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2006.260517     Document Type: Conference Paper

References (7)

1. Johnson, M.D., K.J. Otto, and D.R. Kipke, Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2005.13(2): p. 160-165.
2. Retterer, S.T., et al., Model neural prostheses with integrated microfluidics: A potential intervention strategy for controlling reactive cell and tissue responses. IEEE Transactions on Biomedical Engineering, 2004. 51(11): p. 2063-2073.
3. Shain, W., et al., Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2003. 11(2): p. 186-188.
4. Spataro, L., et al., Dexamethasone treatment reduces astroglia responses to inserted neuroprosthetic devices in rat neocortex. Experimental Neurology, 2005. 194(2): p. 289-300.
5. Subbaroyan, J., Martin, D.C., and Kipke, D.R., A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex. Journal of Neural Engineering, 2005. 2: p. 103-113.
6. Biran, R., D.C. Martin, and P.A. Tresco, Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Experimental Neurology, 2005. 195(1): p. 115-126.
7. Kim, Y.T., et al., Chronic response of adult rat brain tissue to implants anchored to the skull. Biomaterials, 2004. 25(12): p. 2229-2237.