Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 5, 2007, Pages 388-392

  Lee, Kyung Hwan ^a   Lee, Byung Mu ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYCITRIC ACID;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GARCINIA CAMBOGIA; GENOTOXICITY; LIVER MICROSOME METABOLISM; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; CELL LINE; CHROMOSOME ABERRATIONS; CITRATES; CRICETINAE; CRICETULUS; GARCINIA CAMBOGIA; MICE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS;

BACTERIA (MICROORGANISMS); GARCINIA CAMBOGIA;

EID: 34047141120     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390600882192     Document Type: Article

References (27)

1. Ames, B. N., Mccann, J., and Yamasaki, E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:347-364.
2. Aydemir, N., and Bilaloglu, R. 2003. Genotoxicity of two anticancer drugs, gemcitabine and topotecan, in mouse bone marrow in vivo. Mutat. Res. 537:43-51
3. Chanda, S., Erexson, G., Riach, C., Innes, D., Stevenson, F., Murli, H., and Bley, K. 2004. Genotoxicity studies with pure trans-capsaicin. Mutat. Res. 557:85-97.
4. Choi, M. J., Lee, J. W., and Lee, B. M. 1996. Comparative assessment of DNA adduct formation, Salmonella mutagenicity, and chromosome aberration assays as short-term tests for DNA damage. J. Toxicol. Environ. Health 49:271-284.
5. Conte, A. A. 1993. A non-prescription alternative in weight reduction therapy. Am. J. Bariat. Med. Summer:17-19.
6. Czyz, A., Szpilewska, H., Dutkiewicz, R., Kowalska, W., Biniewska-Godlewska, A., and Wegrzyn, G. 2002. Comparison of the Ames test and a newly developed assay for detection of mutagenic pollution of marine environments. Mutat. Res. 519:67-74.
7. Greenwood, M. R. C., Cleary, M. P., Gruen, R., Blasé, D., Stern, J. S., Triscari, J., and Sullivan, A. C. 1981. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am. J. Physiol. 240:E72-E78.
8. Ishihara, K., Oyaizu, S., Onuki, K., Lim, K., and Fushiki, T. 2000. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J. Nutr. 130:2990-2995.
9. Johannsen, F. R. 2003. Toxicological profile of carboxymethyl inulin. Food. Chem. Toxicol. 41:49-59.
10. Kirkland, D., and Marzin, D. 2003. An assessment of the genotoxicity of 2-hydroxy-1,4-naphthoquinone, the natural dye ingredient of henna. Mutat. Res. 537:183-199.
11. Kovacs, E. M., Westerterp-Plantenga, M. S., de Vries, M., Brouns, F., and Saris, W. H. 2001. Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake. Physiol. Behav. 74:543-549.
12. Lewis, Y. S., and Neelakantan, S. 1965. (-)-Hydroxycitric acid - The principal acid in the fruits of Garcinia cambogia Desr. Phytochemistry. 4:619-625.
13. Loe, Y. C., Bergeron, N., Rodriguez, N., and Schwarz, J.-M. 2001. Gas chromatography/ mass spectrometry method to quantify blood hydroxycitrate concentration. Anal. Biochem. 292:148-154.
14. Maron, D. M. and Ames, B. N. 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:173-215.
15. Mattes, D. R. and Bormann, L. 2000. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol. Behav. 71:87-94.
16. Mortelmans, K., and Zeiger, E. 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res. 455:29-60.
17. Ohia, S. E., Awe, O., LeDay, A. M., Opere, C. A., and Bagchi, D. 2001. Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Res. Commun. Mol. Pathol. Pharmacol. 109:210-216.
18. Ohia, S. E., Opere, C. A., LeDay, A. M., Bagchi, M., Bagchi, D., and Stohs, S. J. 2002. Safety and mechanism of appetite suppression by novel hydroxycitric acid extract (HCA-SX). Mol. Cell. Biochem. 238:89-103.
19. Rao, R. N., and Sakaria, K. K. 1988. Lipid-lowering and antiobesity effect of (-)-hydroxycitric acid. Nutr. Res. 8:209-212.
20. Sergio, W. 1988 A natural food, the Malabar tamarind, may be effective in the treatment of obesity. Med. Hypotheses. 29: 39-40.
21. Sullivan, A. C., Triscari, J., Hamilton, J. G., and Miller, O. N. 1974. Effect of (-)-hydroxycitric acid upon the accumulation of lipid in the rat: II. Appetite. Lipids 9:129-134.
22. Sullivan, A. C., and Triscari, J. 1977. Metabolic regulation as a control for lipid disorders. I. Influence of (-)-hydroxycitrate on experimentally induced obesity in the rodent. Am. J. Clin. Nutr. 30:767-776.
23. Sullivan, A. C., Triscari, J., and Spiegel, H. E. 1977. Metabolic regulation as a control for lipid disorders. II. Influence of (-)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. Am. J. Clin. Nutr. 30:777-784.
24. Varanda, E. A., Pozetti, G. L., Lourenco, M. V., Vilegas, W., and Raddi, M. S. 2002. Genotoxicity of Brosimum gaudichaudii measured by the Salmonella/ microsome assay and chromosome aberrations in CHO cells. J. Ethnopharmacol. 81:257-264
25. Vasselli, J. R., Shane, E., Boozer, C. N., and Heymsfield, S. B. 1998. Garcinia cambogia extract inhibits body weight gain via increased energy expenditure (EE) in rats. FASEB J. 12: A505.
26. Watson, J. A., Fang, M., and Lowenstein, J. M. 1969. Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: citrate oxaloacetate lyase. Arch. Biochem. Biophys. 135:209-217.
27. Westerterp-Plantenga, M. S., and Kovacs, E. M. R. 2002. The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. Int. J. Obes. 26:870-872.