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Volumn 35, Issue 4, 2007, Pages 521-524

Characterization of two cyclic metabolites of sitagliptin

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE; DRUG METABOLITE; PIPERAZINE; SITAGLIPTIN;

EID: 34047112815     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013128     Document Type: Article
Times cited : (11)

References (11)
  • 1
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    • Beconi MG, Reed JR, Teffera Y, Xia Y-Q, Kochansky CJ, Liu, DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, et al. (2007) Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. 35:000-000.
    • Beconi MG, Reed JR, Teffera Y, Xia Y-Q, Kochansky CJ, Liu, DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, et al. (2007) Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. 35:000-000.
  • 2
    • 34047119046 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic food effect and evaluation of the definitive bioavailability of sitagliptin (MK-0431), an oral dipeptidyl peptidase-IV inhibitor
    • Bergman A, Krishna R, Ebel D, Liu F, Stone J, Wang A, Zeng W, Chen L, Dilzer S, Lasseter K, et al. (2005) Lack of a pharmacokinetic food effect and evaluation of the definitive bioavailability of sitagliptin (MK-0431), an oral dipeptidyl peptidase-IV inhibitor. J Clin Pharm 45:1089.
    • (2005) J Clin Pharm , vol.45 , pp. 1089
    • Bergman, A.1    Krishna, R.2    Ebel, D.3    Liu, F.4    Stone, J.5    Wang, A.6    Zeng, W.7    Chen, L.8    Dilzer, S.9    Lasseter, K.10
  • 3
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebocontrolled study in healthy male volunteers
    • Bergman AJ, Stevens C, Zhou YY, Yi B, Laethem M, De Smet M, Snyder K, Hilliard D, Tanaka W, Zeng W, et al. (2006) Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebocontrolled study in healthy male volunteers. Clin Ther 28:55-72.
    • (2006) Clin Ther , vol.28 , pp. 55-72
    • Bergman, A.J.1    Stevens, C.2    Zhou, Y.Y.3    Yi, B.4    Laethem, M.5    De Smet, M.6    Snyder, K.7    Hilliard, D.8    Tanaka, W.9    Zeng, W.10
  • 4
    • 33845491342 scopus 로고    scopus 로고
    • Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes
    • Herman G, Hanefeld M, Wu M, Chen X, Zhao P, and Stein P (2005a) Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes. Diabetes 54 (Suppl 1):A134.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 1
    • Herman, G.1    Hanefeld, M.2    Wu, M.3    Chen, X.4    Zhao, P.5    Stein, P.6
  • 7
    • 19944427998 scopus 로고    scopus 로고
    • (2R)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4, 5-trifluorophenyl)butan-2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    • Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey G-J, Kowalchick JE, Leiting B, Lyons K, et al. (2005) (2R)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4, 5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem 48:141-151.
    • (2005) J Med Chem , vol.48 , pp. 141-151
    • Kim, D.1    Wang, L.2    Beconi, M.3    Eiermann, G.J.4    Fisher, M.H.5    He, H.6    Hickey, G.-J.7    Kowalchick, J.E.8    Leiting, B.9    Lyons, K.10
  • 9
    • 0034810759 scopus 로고    scopus 로고
    • Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification
    • Liu DQ, Hop CE, Beconi MG, Mao A, and Chiu SH (2001) Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification. Rapid Commun Mass Spectrom 15:1832-1839.
    • (2001) Rapid Commun Mass Spectrom , vol.15 , pp. 1832-1839
    • Liu, D.Q.1    Hop, C.E.2    Beconi, M.G.3    Mao, A.4    Chiu, S.H.5
  • 10
    • 31144459380 scopus 로고    scopus 로고
    • Twelve-week efficacy and tolerability of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in the treatment of type 2 diabetes (T2D)
    • Scott R, Herman G, Zhao P, Chen X, Wu M, and Stein P (2005). Twelve-week efficacy and tolerability of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in the treatment of type 2 diabetes (T2D). Diabetes 54 (Suppl 1):A10.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 1
    • Scott, R.1    Herman, G.2    Zhao, P.3    Chen, X.4    Wu, M.5    Stein, P.6
  • 11
    • 34047097841 scopus 로고    scopus 로고
    • 14C]sitagliptin in humans. Drug Metab Dispos 35:000-000.
    • 14C]sitagliptin in humans. Drug Metab Dispos 35:000-000.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.