Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore

Phytochemistry

Volumn 68, Issue 8, 2007, Pages 1200-1205

  Pillay, Pamisha ^a   Vleggaar, Robert ^b   Maharaj, Vinesh J ^a   Smith, Peter J ^c   Lategan, Carmen A ^c   Chouteau, Frank ^c   Chibale, Kelly ^c  

^a DSI CSIR Nanotechnology Innovation Centre   (South Africa)

^b UNIVERSITY OF PRETORIA   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

2(5H) furanone; Antiplasmodial activity; Cytotoxicity; Hirsutinolides; Mucochloric and mucobromic acids; Pharmacophores; Plasmodium falciparum; Vernonia staehelinoides

Indexed keywords

8ALPHA (2 METHYLACRYLOYLOXY) 3 OXO 1 DESOXY 1,2 DEHYDROHIRSUTINOLIDE 13 O ACETATE; 8ALPHA (5' ACETOXYSENECIOYLOXY) 3 OXO 1 DESOXY 1,2 DEHYDROHIRSUTINOLIDE 13 O ACETATE; 8ALPHA-(2-METHYLACRYLOYLOXY)-3-OXO-1-DESOXY-1,2-DEHYDROHIRSUTINOLIDE-13-O-ACETATE; 8ALPHA-(5'-ACETOXYSENECIOYLOXY)-3-OXO-1-DESOXY-1,2-DEHYDROHIRSUTINOLIDE-13-O-ACETATE; ANTIMALARIAL AGENT; FURAN DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; FRACTIONATION; HAMSTER; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE; PLANT LEAF; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; VERNONIA;

ANIMALS; ANTIMALARIALS; BINDING SITES; CHEMICAL FRACTIONATION; CHO CELLS; CRICETINAE; CRICETULUS; FURANS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS; PLANT LEAVES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; VERNONIA;

ASTERACEAE; CRICETULUS GRISEUS; MAMMALIA; PLASMODIUM FALCIPARUM; VERNONIA;

EID: 34047111418     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2007.02.019     Document Type: Article

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