Engagement of the CD160 activating NK cell receptor leads to its association with CD2 in circulating human NK cells

Transplant Immunology

Volumn 17, Issue 1, 2006, Pages 36-38

  Rabot, Magali ^a   Bensussan, Armand ^b,c   Le Bouteiller, Philippe ^a  

^a CHU PURPAN   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

Glycosylphosphatidylinositol; Monoclonal antibodies; Peripheral blood; Phosphatidylinositol 3kinase

Indexed keywords

CD160 RECEPTOR; CD2 ANTIGEN; NATURAL KILLER CELL RECEPTOR;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID RAFT; NATURAL KILLER CELL; POLARIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD; ANTIGENS, CD2; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; RECEPTORS, IMMUNOLOGIC;

EID: 34047097304     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2006.09.031     Document Type: Article

References (12)

1. Moretta L., Bottino C., Pende D., Castriconi R., Mingari M.C., and Moretta A. Surface NK receptors and their ligands on tumor cells. Semin Immunol 18 3 (2006) 151-158
2. Vivier E., Nunes J.A., and Vely F. Natural killer cell signaling pathways. Science 306 5701 (2004) 1517-1519
3. Agrawal S., Marquet J., Freeman G.J., Tawab A., Le Bouteiller P., Roth P., et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J Immunol 162 3 (1999) 1223-1226
4. Anumantha A., Bensussan A., Boumsell L., Christ A., Blumberg R., Voss S., et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol 161 6 (1998) 2780-2790
5. Barakonyi A., Rabot M., Marie-Cardine A., Aguerre-Girr M., Polgar B., Schiavon V., et al. Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. J Immunol 173 9 (2004) 5349-5354
6. Le Bouteiller P., Barakonyi A., Giustiniani J., Lenfant F., Marie-Cardine A., Aguerre-Girr M., et al. Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Proc Natl Acad Sci U S A 99 26 (2002) 16963-16968
7. Maeda M., Carpetino C., Russell R., Dasanjh J., Veinotte L., Ohta H., et al. Murine CD160, Ig-like receptor on NK cells and NKT cells, recognizes classical and non classical MHC class I and regulates NK cell activation. J Immunol 175 7 (2005) 4426-4432
8. Tsujimura K., Obata Y., Matsudaira Y., Nishida K., Akatsuka Y., Ito Y., et al. Characterization of murine CD160(+) CD8(+) T lymphocytes. Immunol Lett 106 1 (2006) 48-56
9. Fons P., Chabot S., Cartwright J.E., Lenfant F., L'Faqihi F., Giustiniani J., et al. Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells. Blood 108 8 (2006) 2608-2615
10. McNerney M.E., and Kumar V. The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol 298 (2006) 91-120
11. MacFarlane IV A.W., and Campbell K.S. Signal transduction in natural killer cells. Curr Top Microbiol Immunol 298 (2006) 23-57
12. Inoue H., Miyaji M., Kosugi A., Nagafuku M., Okazaki T., Mimori T., et al. Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with phosphatidylinositol 3-kinase and phospholipase C-gamma following CD2 stimulation. Eur J Immunol 32 8 (2002) 2188-2198