Effects of kraft pulp mill condensates on plasma testosterone levels in mummichog (Fundulus heteroclitus)

Ecotoxicology and Environmental Safety

Volumn 67, Issue 1, 2007, Pages 140-148

  Shaughnessy, Kevin S ^a   Belknap, Andrew M ^b,c   Hewitt, L Mark ^c   Dubé, Monique G ^d   MacLatchy, Deborah L ^a  

^a UNIVERSITY OF NEW BRUNSWICK   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c ENVIRONMENT CANADA   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Bleached kraft pulp mill; Condensates; Fundulus heteroclitus; Hormonally active substances; Testosterone

Indexed keywords

SEX HORMONE; TESTOSTERONE;

BIOASSAY; DOSE-RESPONSE RELATIONSHIP; ENDOCRINE DISRUPTOR; INDUSTRIAL WASTE; PULP AND PAPER INDUSTRY; TELEOST; TESTOSTERONE; TOXICITY TEST;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CANADA; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FISH; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE ACTION; MALE; NONHUMAN; PULP MILL; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL; TOXICITY TESTING;

ANIMALS; BIOLOGICAL ASSAY; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FUNDULIDAE; GONADS; INDUSTRIAL WASTE; MALE; NEW BRUNSWICK; REPRODUCTION; SEX FACTORS; TESTOSTERONE; WATER POLLUTANTS, CHEMICAL; WOOD;

CANADA; NEW BRUNSWICK; NORTH AMERICA; SAINT JOHN [NEW BRUNSWICK];

FUNDULUS HETEROCLITUS;

EID: 34047092229     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2006.04.003     Document Type: Article

References (34)

1. Belknap A., Shaughnessy K.S., MacLatchy D.L., Solomon K., and Hewitt M.L. Method development for the identification of hormonally active components in bleached kraft chemical recovery condensates. In: Borton D.L., Hall T.J., Fisher R.P., and Thomas J.F. (Eds). Pulp and Paper Mill Effluent Environmental Fate and Effects (2004), DEStech Publications, Inc., Lancaster, PA, USA 374-383
2. Belknap, A., Solomon, K.R., Dubé, M.G., MacLatchy, D.L., Hewitt, M.L., 2006. Identification of compounds associated with testosterone depressions in fish exposed to bleached kraft pulp and paper mill chemical recovery condensates. Environ. Toxicol. Chem. 25 (9), in press.
3. Dubé M.G., and MacLatchy D.L. Endocrine responses of Fundulus heteroclitus to effluent from a bleached-kraft pulp mill before and after installation of reverse osmosis treatment of a waste stream. Environ. Toxicol. Chem. 19 (2000) 2788-2796
4. Dubé M.G., and MacLatchy D.L. Identification and treatment of a waste stream at a bleached-kraft pulp mill that depresses a sex steroid in the mummichog (Fundulus heteroclitus). Environ. Toxicol. Chem. 20 (2001) 985-995
5. Hewitt M.L., Carey J.H., Dixon G.D., and Munkittrick K.R. Examination of bleached kraft mill effluent fractions for potential inducers of mixed function oxygenase activity in rainbow trout. In: Servos M.R., Munkittrick K.R., Carey J.H., and Van Der Kraak G.J. (Eds). Environmental Fate and Effects of Pulp and Paper Mill Effluents (1996), St. Lucie Press, Delray Beach, FL, USA 79-94
6. Hewitt M.L., Parrott J.L., Wells K.L., Calp M.K., Biddiscombe S., McMaster M.E., Munkittrick R., and Van Der Kraak G.J. Characteristics of ligands for the Ah receptor and sex steroid receptors in hepatic tissues of fish exposed to bleached kraft mill effluent. Environ. Sci. Technol. 34 (2000) 4327-4334
7. Hewitt M.L., Smythe S.A.M., Dubé M.G., Gilman C.I., and MacLatchy D.L. Isolation of compounds from bleached kraft mill recovery condensates associated with reduced levels of testosterone in mummichog (Fundulus heteroclitus). Environ. Toxicol. Chem. 21 (2002) 1359-1367
8. Hewitt M.L., Dubé M.G., Culp J.M., MacLatchy D.L., and Munkittrick K.R. A proposed framework for investigation of cause for environmental effects monitoring. Hum. Ecol. Risk Assess. 19 (2003) 195-211
9. Hewitt M.L., Pryce A.C., Parrott J.L., Marlatt V., Wood C., Oaks K., and Van Der Kraak G.J. Accumulation of ligands for aryl hydrocarbon and sex steroid receptors in fish exposed to treated effluent from a bleached sulfite/groundwood pulp and paper mill. Environ. Toxicol. Chem. 22 (2003) 2890-2897
10. Kanji, G.K., 1993. 100 Statistical Tests. SAGE Publications, London, UK, 224pp.
11. Karels A.E., Soimasuo M., Lappivaara J., Leppänen H., Aaltonen T., Mellanen P., and Oikari A.O.J. Effects of ECF-bleached kraft mill effluent on reproductive steroids and liver MFO activity in populations of perch and roach. Ecotoxicology 7 (1998) 123-132
12. Leblanc J., Coulliard C.M., and Brêthes J.-C.F. Modifications of the reproductive period in mummichog (Fundulus heteroclitus) living downstream from a bleached kraft pulp mill in the Miramichi Estuary, New Brunswick, Canada. Can. J. Fish. Aquat. Sci. 54 (1997) 2564-2573
13. Leusch F.D.L., and MacLatchy D.L. In vivo implants of β-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus). Gen. Comp. Endocrinol. 134 (2003) 255-263
14. MacLatchy D.L., Courtenay S.C., Rice C.D., and Van Der Kraak G.J. Development of a short-term reproductive endocrine bioassay using steroid hormone and vitellogenin endpoints in the estuarine mummichog (Fundulus heteroclitus). Environ. Toxicol. Chem. 22 (2003) 996-1008
15. MacLatchy D.L., Gormley K.L., Ibey R.E.M., Sharpe R.L., Shaughnessy K.S., Courtenay S.C., Dubé M., and Van der Kraak G.J. A short-term mummichog (Fundulus heteroclitus) bioassay to assess endocrine response to hormone-active compounds and mixtures. In: Ostrander G.K. (Ed). Techniques in Aquatic Toxicology vol. 2 (2005), CRC Press, New York 55-92
16. McMaster M.E. A review of the evidence for endocrine disruption in Canadian aquatic ecosystems. Water Qual. Res. J. Can. 36 (2001) 215-231
17. McMaster M.E., Van Der Kraak G.J., Portt C.B., Munkittrick K.R., Sibley P.K., Smith I.R., and Dixon D.G. Changes in hepatic mixed function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sucker (Catostomus commersoni) population exposed to bleached kraft pulp mill effluent. Aquat. Toxicol. 21 (1991) 199-218
18. McMaster M.E., Munkittrick K.R., and Van Der Kraak G.J. Protocol for measuring circulating levels of gonadal sex steroids in fish. Can. Tech. Rep. Fish. Aquat. Sci. 1836 (1992) 1-29
19. McMaster M.E., Munkittrick K.R., Van Der Kraak G.J., Flett P.A., and Servos M.R. Detection of steroid hormone disruptions associated with pulp mill effluent using artificial exposures of goldfish. In: Servos M.R., Munkittrick K.R., Carey J.H., and Van Der Kraak G.J. (Eds). Environmental Fate and Effects of Pulp and Paper Mill Effluents (1996), St. Lucie Press, Delray Beach, FL, USA 425-437
20. Munkittrick K.R. Environmental effects of effluents from pulp and paper mills. In: Northcote T.G., and Hartman G.F. (Eds). Fishes and Forests: Worldwide Watershed Interactions and Management (2003), Blackwell Science, Oxford 336-361
21. Munkittrick K.R., Portt C.B., Van Der Kraak G.J., Smith I.R., and Rokosh D.A. Impact of bleached kraft mill effluent on population characteristics, liver MFO activity, and serum steroid levels of a Lake Superior white sucker (Catostomus commersoni) population. Can. J. Fish. Aquat. Sci. 48 (1991) 1371-1380
22. Munkittrick K.R., McMaster M.E., Portt C.B., Van Der Kraak G.J., Smith I.R., and Dixon D.G. Changes in maturity, plasma sex steroid levels, hepatic MFO activity and the presence of external lesions in lake whitefish exposed to bleached kraft mill effluent. Can. J. Fish. Aquat. Sci. 49 (1992) 1560-1569
23. Munkittrick K.R., Van Der Kraak G.J., McMaster M.E., and Portt C.B. Response of hepatic MFO activity and plasma sex steroids to secondary treatment of bleached kraft pulp mill effluent and mill shutdown. Eviron. Toxicol. Chem. 11 (1992) 1427-1439
24. Munkittrick K.R., Van Der Kraak G.J., McMaster M.E., Portt C.B., van den Heuvel M.R., and Servos M.R. Survey of receiving water environmental impacts associated with discharges from pulp mills. II. Gonad size, liver size, hepatic EROD activity and plasma sex steroid levels in white sucker. Environ. Toxicol. Chem. 13 (1994) 1089-1101
25. Munkittrick K.R., McMaster M.E., McCarthy L.H., Servos M.R., and Van Der Kraak G.J. An overview of recent studies on the potential of pulp-mill effluents to alter reproductive parameters in fish. J. Toxicol. Environ. Health B1 (1998) 347-371
26. Munkittrick K.R., McGeachy S.A., McMaster M.E., and Courtenay S.C. Overview of freshwater fish studies from the pulp and paper environmental effects monitoring program. Water Qual. Res. J. Can. 37 (2002) 49-77
27. Parrott J.L., and Wood C.S. Fathead minnow lifecycle tests for detection of endocrine-disrupting substances in effluents. Water Qual. Res. J. Can. 37 (2002) 651-667
28. Robinson, R.D., 1994. Evaluation and development of laboratory protocols for estimating reproductive impacts of pulp mill effluent on fish. Ph.D. Thesis, University of Guelph, Guelph, ON, Canada.
29. Sandström O., Neuman E., and Karås P. Effects of bleached pulp mill effluent on growth and gonad function in Baltic coastal fish. Water Sci. Technol. 20 (1988) 107-118
30. Sepúlveda M.S., Gallagher E.P., Weiser C.M., and Gross T.S. Reproductive and biochemical biomarkers in largemouth bass sampled downstream of a pulp and paper mill in Florida. Ecotoxicol. Environ. Saf. 57 (2004) 431-440
31. Sharpe R.L., MacLatchy D.L., Courtenay S.C., and Van Der Kraak G.J. Effects of a model androgen (methyl testosterone) and a model anti-androgen (cyproterone acetate) on reproductive endocrine endpoints in a short-term adult mummichog (Fundulus heteroclitus) bioassay. Aquat. Toxicol. 67 (2004) 203-215
32. Sohoni P., and Sumpter J.P. Several environmental estrogens are also anti-androgens. J. Endocrinol. 158 (1998) 327-339
33. Van Der Kraak G.J., Munkittrick K.R., McMaster M.E., Portt C.B., and Chang J.P. Exposure to bleached kraft pulp mill effluent disrupts the pituitary-gonadal axis of white sucker at multiple sites. Toxicol. Appl. Pharmacol. 115 (1992) 224-233
34. Zar, J.H., 1999. Biostatistical Analysis, fourth ed. Prentice-Hall, Upper Saddle River, NJ, pp. 303-311.